Sex hormone levels and expression of their receptors in lactating and lactating pregnant rats

González-Arenas, Aliesha; Jiménez-Arellano, Carolina; Morimoto, Sumiko; Galvan-Rosas, Agustin; Gómora‐Arrati, Porfirio; García‐Juárez, Marcos; González‐Flores, Oscar

doi:10.1016/j.jsbmb.2017.12.015

Cited by 6 publications

(2 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animals were euthanized on PD 11 or 12 under basal conditions by rapid decapitation. Importantly, this mid-postpartum time point corresponds with a return of estradiol levels to basal levels, following a peak at the end of gestation that steadily decreases through PD 14 ( Camacho-Arroyo et al, 2018 ). Trunk blood was collected in EDTA-coated tubes (Sarstedt) and immediately chilled in ice.…”

Section: Methodsmentioning

confidence: 95%

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gorman-Sandler

Robertson

Crawford

et al. 2023

Neurobiology of Stress

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 95%

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gorman-Sandler

Robertson

Crawford

et al. 2023

Neurobiology of Stress

View full text Add to dashboard Cite

“…Importantly, this mid-postpartum time point corresponds with a return of estradiol levels to basal levels, following a peak at the end of gestation that steadily decreases through PD 14 (Camacho-Arroyo et al, 2018). Trunk blood was collected in EDTA-coated tubes (Sarstedt) and immediately chilled in ice.…”

Section: Euthanasia and Tissue Collectionmentioning

confidence: 99%

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gorman-Sandler

Robertson

Crawford

et al. 2022

Preprint

View full text Add to dashboard Cite

Postpartum depression (PPD) is a major psychiatric complication of childbirth, affecting up to 20% of mothers, yet remains understudied. Mitochondria, dynamic organelles crucial for cell homeostasis and energy production, share links with many of the proposed mechanisms underlying PPD pathology. Brain mitochondrial function is affected by stress, a major risk factor for development of PPD, and is linked to anxiety-like and social behaviors. Considering the importance of mitochondria in regulating brain function and behavior, we hypothesized that mitochondrial dysfunction is associated with behavioral alterations in a chronic stress-induced rat model of PPD. Using a validated and translationally relevant chronic mild unpredictable stress paradigm during late gestation, we induced PPD-relevant behaviors in adult postpartum Wistar rats. In the mid-postpartum, we measured mitochondrial function in the prefrontal cortex (PFC) and nucleus accumbens (NAc) using high-resolution respirometry. We then measured protein expression of mitochondrial complex proteins and 4-hydroxynonenal (a marker of oxidative stress), and Th1/Th2 cytokine levels in PFC and plasma. We report novel findings that gestational stress decreased mitochondrial function in the PFC, but not the NAc of postpartum dams. However, in groups controlling for the effects of either stress or parity alone, no differences in mitochondrial respiration measured in either brain regions were observed compared to nulliparous controls. This decrease in PFC mitochondrial function in stressed dams was accompanied by negative behavioral consequences in the postpartum, complex-I specific deficits in protein expression, and increased Tumor Necrosis Factor alpha cytokine levels in plasma and PFC. Overall, we report an association between PFC mitochondrial respiration, PPD-relevant behaviors, and inflammation following gestational stress, highlighting a potential role for mitochondrial function in postpartum health.

show abstract

Role of pregnancy hormones and hormonal interaction on the maternal cardiovascular system: a literature review

2019

View full text Add to dashboard Cite

Sex hormone levels and expression of their receptors in lactating and lactating pregnant rats

Cited by 6 publications

References 62 publications

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats

Role of pregnancy hormones and hormonal interaction on the maternal cardiovascular system: a literature review

Contact Info

Product

Resources

About