Sex hormone-binding globulin, serum testosterone, and androgen receptors in the skin in papulopustular and conglobata forms of acne vulgaris

Kushlinskii, N. E.; Salamova, I. V.; Masyukova, S. A.; Muhammad, A; Degtyar, V. G.; Samsonov, V. A.

doi:10.1007/bf02766441

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…4 The skin is a typical target tissue for androgens and testosterone, a major androgen in human blood that stimulates many metabolic processes in the endothelium of sebaceous gland. 5 Raised androgen levels (testosterone, androstenedione, dehydroepiandrosterone, dehydroepi-androsterone sulphate) in women with acne have been repeatedly demonstrated in many studies. Androgens enhance the sebum production and follicular keratosis that plays the key role in the aetiology of acne.…”

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confidence: 99%

Association of Serum Testosterone with Acne Vulgaris in Women

Rahman¹,

Sikder

Rashid

et al. 2012

Bangabandhu Sheikh Mujib Medical University Journal

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Background: Androgens enhance the sebum production and follicular keratosis that plays the key role in the aetiology of acne. Objective: To find out the association between serum testosterone and acne vulgaris. Methods: A case control study was carried out for a period of two years in the outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Female patients having acne vulgaris were selected as case. Healthy control (age and sex matched) were enrolled from the community. Results: The study showed that the mean age of the cases was 22.43 with standard deviation 5.2 years and the mean age of the control was 23.23 with standard deviation 5.9 years. The mean duration of disease was 62.6 months ranging from 12 months to 300 months. All the patients had presented with comedones (blackheads and whiteheads) followed by 94.3% had papules and 58.6% had pustules. Considering the site of lesion, all the patients had acne in the face. Data analysis revealed that the percentage of serum testosterone above normal was found to be high among the cases with acne (10%) whereas below normal level of serum testosterone was found among the control and the difference was statistically significant (p<0.001). Conclusion:The study found a significant association between serum testosterone and acne vulgaris. As serum testosterone is associated with acne vulgaris, testosterone levels should be measured in patients presenting with acne vulgaris especially in treatment resistant cases and anti-androgen treatment may be indicated in cases with elevated testosterone level.DOI: http://dx.doi.org/10.3329/bsmmuj.v5i1.10980 BSMMU J 2012; 5(1):1-5

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confidence: 99%

Association of Serum Testosterone with Acne Vulgaris in Women

Rahman¹,

Sikder

Rashid

et al. 2012

Bangabandhu Sheikh Mujib Medical University Journal

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“…15,16 In a study by Lawrence et al, free and total testosterone levels in plasma were significantly increased in females with acne vulgaris and this finding was in agreement with the results of this study. 17 Testosterone is the major androgen in human blood that encourages many metabolic processes in the epithelium of the sebaceous gland, 18 since androgen promotes sebum production and its excretion ability will result in amassing of sebum in the definite sites of the body. 19,20 The findings of our study are supported by the finding of the studies by Hatwal et al and Held et al, who concluded that females with acne had a significantly higher level of serum testosterone than controls.…”

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confidence: 99%

Study of Levels of Free Testosterone in Patients with Acne Vulgaris before and after Treatment

Gupta¹,

Bajwa²,

Ghosh³

et al. 2021

Indian Journal of Medical Biochemistry

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Pattern of acne vulgaris in women, attending in a tertiary care hospital

Khondker

Rahman

Mahmud

et al. 2012

J. Dhaka Natl. Med. Coll. Hosp.

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A cross-sectional study was carried out for a period of one year in the outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Seventy female patients having acne vulgaris were selected. The study showed that the mean age of the cases was 22.43 with standard deviation 5.2 years and highest percentage of patients were in the age group 20-24 years (41.4%), highest percentage of patients was unmarried among the cases (74.3%) and proportion of secondary (35.7%) and higher secondary education (20%) were found to be high among the cases. The study showed that proportion of student (65.7%) and housewife (17.1%) were found to be high among the cases. The mean duration of disease was 62.6 months and all the patients had presented with comedones (blackheads and whiteheads). All the patients had acne in the face and it was found that 60% had moderate type acne. Considering the pattern of treatment received, 42.9% of the patients mentioned that they used topical ointment, 37.1% had received herbal medication and 25.7% had received systemic medication. To get an overall impression of the country regarding acne vulgaris, more integrated study is needed. This was a study on a limited number of cases. Future studies must include economical support, then large sample size could be ensured and study finding would be more reliable. There is a great need of epidemiological studies also, with sufficient follow-up, systematic reviews and meta-analyses on this issue. DOI: http://dx.doi.org/10.3329/jdnmch.v18i1.12234 J. Dhaka National Med. Coll. Hos. 2012; 18 (01): 18-23

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Sex hormone-binding globulin, serum testosterone, and androgen receptors in the skin in papulopustular and conglobata forms of acne vulgaris

Cited by 3 publications

References 12 publications

Association of Serum Testosterone with Acne Vulgaris in Women

Association of Serum Testosterone with Acne Vulgaris in Women

Study of Levels of Free Testosterone in Patients with Acne Vulgaris before and after Treatment

Pattern of acne vulgaris in women, attending in a tertiary care hospital

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