Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME study

Bataille, Vincent; Fougère, Bertrand; Evans, Alun; Amouyel, Philippe; Arveiler, Dominique; Ducimetière, Pierre; Bard, Jean‐Marie; Ferrières, Jean

doi:10.1016/j.atherosclerosis.2004.10.029

Cited by 62 publications

(64 citation statements)

References 24 publications

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“…Therefore, taking SHBG into account (either by adjustment of SHBG or by assessment using FT or Endogenous testosterone and lipid profile B-P Jiann et al BT) is critical to discern the effect of TT on TGs and HDL-C. When the confounding effect of SHBG was considered, insignificant correlation of TT and fasting TGs was reported in other studies, 6,10,22,23 which was compatible with our finding. The relationship of testosterone and postprandial TGs has been seldom addressed.…”

Section: Discussionsupporting

confidence: 90%

“…It is hypothesized that increased visceral fat, which is associated with low testosterone levels, 25 leads to overproduction of very low-density lipoprotein particles 26 and these particles compete with dietary TGs for the same clearance mechanism, and causes the elevation of postprandial TGs. 27 When the effect of SHBG was taken into account, divergent results were reported in the association between testosterone and HDL-C, with most reporting no association 6,20,23,28 and some reporting an inverse 10 or a positive association 29,30 between them. The inconsistency may come from methodological difference or from the true difference in the study populations.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies reported no correlation between them, 6,10,17,21,23,31 and several studies reported an unfavorable association of testosterone with TC, LDL-C and apoprotein B. 6,7,29 According to the evidences that every 1.0 mg dl À1 elevation in HDL-C levels and decrease in LDL-C levels may reduce the risk of cardiovascular disease by 2-4% 32 and 0.6%, 33 respectively, Endogenous testosterone and lipid profile B-P Jiann et al and the magnitudes of associations of testosterone with HDL-C and LDL-C shown in this study, the unfavorable effect of testosterone on LDL-C for cardiovascular system neutralizes the favorable effect of testosterone on HDL-C.…”

Section: Discussionmentioning

confidence: 99%

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Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

et al. 2011

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The relationship between endogenous plasma testosterone and plasma lipids was assessed among 856 Taiwanese men^40 years old originally recruited for an epidemiological study of testosterone deficiency syndrome. Blood samples were drawn from fasting (n ¼ 562) and non-fasting (n ¼ 294) subjects between 0800 to 1100 hours. With adjustment of age, body mass index and sex hormonebinding globulin, the following results were shown: (i) triglyceride (TG) levels were negatively associated with quartile levels of testosterone, and the magnitudes of associations were greater for postprandial TGs than for fasting TGs; (ii) high-density lipoprotein cholesterol (HDL-C) levels were positively related to quartile levels of testosterone, but the associations became insignificant after further control of TGs; and (iii) the calculated low-density lipoprotein cholesterol (LDL-C) levels were positively associated with quartile levels of testosterone. Similar results were obtained in multivariate linear regression analyses with additional control of hypertension and diabetes. In these Taiwanese men, the favorable association of endogenous plasma testosterone with HDL-C counterbalances the unfavorable association of it with LDL-C, while the net influence of testosterone on plasma lipids for cardiovascular system was still in the beneficial direction due to its negative association with postprandial plasma TG levels.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

et al. 2011

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“…Hepatic triglyceride lipase is known to be stimulated by androgens. Therefore, high SHBG would result in low free androgen which maintains low hepatic triglyceride lipase activity ( 37 ). Suppressing hepatic triglyceride lipase would decelerate the conversion of LDL-Ps from large to small and HDL 2 -C to HDL 3 -C (smaller HDLs) ( 16,32,33 ).…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein subclasses and endogenous sex hormones in women at midlife

Khoudary

Brooks

Thurston

et al. 2014

Journal of Lipid Research

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This article is available online at http://www.jlr.org in lipoprotein profi le around the time of menopause, including increases in total cholesterol, triglycerides, ApoB, and LDL cholesterol (LDL-C) ( 1, 4-7 ), which suggest a possible role of endogenous sex hormones. The reduction in plasma estradiol (E2) level that accompanies the menopausal transition has been suggested as a possible mechanism for this alteration of lipid profi les. This hypothesis was supported by the favorable infl uence of hormone therapy (HT) on lipids/lipoproteins ( 8,9 ).The conventional methods of measuring lipid/lipoprotein classes as VLDLs, LDL-C, and HDL cholesterol (HDL-C), provide concentrations of cholesterol carried by the lipoprotein particles rather than the concentration of the particles themselves ( 10 ). The amount of cholesterol per particle varies from person to person, simply because of differences in the relative amounts of cholesterol ester and triglycerides in the particle core, as well as the differences in particle diameter ( 11 ). The NMR spectroscopy method provides a direct measure of lipoprotein particle size, distribution, and concentrations, and therefore may provide a more accurate way to quantify CVD risk. High concentrations of small LDL particles (LDL-Ps) and small HDL particles (HDL-Ps) ( 12, 13 ), and total VLDL particles (VLDL-Ps) and large 14 ) have been found to be associated with greater risk of CVD, while larger LDLand HDL-P sizes are signifi cantly associated with reduced incidence of CVD ( 14 ).Most of the studies which evaluated the associations between endogenous sex hormones and lipid/lipoprotein levels were mainly limited to lipoprotein classes as measured by the conventional methods (15)(16)(17)(18)(19)(20)(21). Results from these studies were not consistent; some failed to report signifi cant associations between lipids and sex hormones after adjusting for BMI ( 17,18 ), while others showed signifi cant associations of E2 (negative) and androgens (positive) with LDL-C and total cholesterol ( 15,16,(18)(19)(20).Abstract The objective of this work was to evaluate the associations between levels of endogenous sex hormones in women at midlife and lipoprotein subclasses. One hundred and twenty women (68 late peri-/postmenopausal and 52 pre-/ early perimenopausal) from the Study of Women's Health Across the Nation (Pittsburgh site) were included. Lipoprotein subclasses were quantifi ed using NMR spectroscopy. Participants (57.5% White and 42.5% Black) were 50.4 ± 1.9 years old. Adjusting for age, race, cycle day of blood draw, BMI, physical activity, and alcohol consumption, a negative correlation was found between estradiol (E2) and mediumsmall LDL particle (LDL-P) concentration ( = ؊ 0.19, P = 0.04). Further, E2 was positively correlated with HDL particle (HDL-P) size ( = 0.22, P = 0.02). For sex hormone binding globulin (SHBG), independent negative correlation was found with total small LDL-P concentration. SHBG was also positively correlated with LDL-P and HDL-P sizes ( P < 0.05 for all). For...

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“…Many studies have shown associations of SHBG with favorable effects on lipid profiles and insulin sensitivity in men (83,84). In women, a high SHBG level was also associated with favorable lipid profiles decrease in the occurrence of cardiovascular disease and metabolic syndrome.…”

Section: Action Of Shbgmentioning

confidence: 98%

Androgen in postmenopausal women

et al. 2012

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Dynamic changes in circulating estradiol level, including increase at menarche and decrease at menopause, occur in a woman's lifetime. Circulating estradiol levels decrease drastically during the menopausal transition, though the levels differ among races. It has been reported that estradiol levels in both Japanese and Chinese women were lower than those in Caucasians, Hispanic and AfricanAmericans (1).Based on data obtained in a previous study (2), we re-analyzed data for 169 healthy men and 252 healthy women aged from 40 to 85 years in the population-based study with addition of data for premenopausal women. Change in circulating estradiol in women from the menopausal transition to postmenopause is characterized as follows : high estradiol level in premenopausal women is drastically decreased and estradiol level in postmenopausal women is significantly lower than that in agematched men. Mean estradiol levels were shown to be 20.1 pg/ml in men and 6.1 pg/ml in postmenopausal women (Figure 1). This dynamic decrease in REVIEW Androgen in postmenopausal women

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Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME study

Cited by 62 publications

References 24 publications

Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

Lipoprotein subclasses and endogenous sex hormones in women at midlife

Androgen in postmenopausal women

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