Sex Hormone-Binding Globulin as an Independent Predictor of Incident Type 2 Diabetes Mellitus in Men

Lakshman, Kishore M.; Bhasin, Shalender; Araujo, Andre B.

doi:10.1093/gerona/glq002

Cited by 81 publications

(98 citation statements)

References 53 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The observed associations were only partially attributable to obesity and insulin resistance [43,44]. Similar prospective studies have also been performed in men, yielding essentially the same results: decreased SHBG levels are associated with higher risks for T2DM e even after adjusting for known risk factors and for total and free T [45,46]. In good agreement with these studies, a nested caseecontrol study in men and postmenopausal women demonstrated that in both sexes low SHBG levels predict development of T2DM [47].…”

Section: Shbg and Its Association With Metabolic Syndrome And Type 2 supporting

confidence: 70%

The biomarker sex hormone-binding globulin – From established applications to emerging trends in clinical medicine

Thaler

Seifert-Klauss

Luppa

2015

Best Practice & Research Clinical Endocrinology & Metab

View full text Add to dashboard Cite

Section: Shbg and Its Association With Metabolic Syndrome And Type 2 supporting

confidence: 70%

The biomarker sex hormone-binding globulin – From established applications to emerging trends in clinical medicine

Thaler

Seifert-Klauss

Luppa

2015

Best Practice & Research Clinical Endocrinology & Metab

View full text Add to dashboard Cite

“…Despite some studies 17 suggesting that middle-aged patients with type 2 diabetes usually present lower levels of testosterone, a recent prospective study showed that free testosterone was not associated with type 2 diabetes and that SHBG may contribute to the risk of type 2 diabetes, through non-androgenic mechanisms. 18 Various authors have investigated the relationship between AGA and cardiovascular involvement, such as hypertension 19,20 or dyslipidaemia. 8 In addition, hyperglycemia and diabetes can be associated with AGA as we show in this case-control study and may contribute to higher frequency of metabolic syndrome and carotid atheromatosis found in these patients.…”

Section: Discussionmentioning

confidence: 99%

Sex hormone–binding globulin and risk of hyperglycemia in patients with androgenetic alopecia

Arias‐Santiago

Gutiérrez-Salmerón

Buendía‐Eisman

et al. 2011

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…Different components of HPT function may 'age' differently and/or respond differentially to health and lifestyle modifications. The age-related increase in sex hormone-binding globulin (SHBG) (17), and its fluctuation in response to changes in metabolic status, can influence bioavailability of testosterone and contribute to alterations in HPT axis function (18,19,20,21,22).…”

Section: Introductionmentioning

confidence: 99%

Age-associated changes in hypothalamic–pituitary–testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study

Camacho

Huhtaniemi

O'Neill

et al. 2013

European Journal of Endocrinology

326

232

View full text Add to dashboard Cite

Objective: Health and lifestyle factors are associated with variations in serum testosterone levels in ageing men. However, it remains unclear how age-related changes in testosterone may be attenuated by lifestyle modifications. The objective was to investigate the longitudinal relationships between changes in health and lifestyle factors with changes in hormones of the reproductive endocrine axis in ageing men. Design: A longitudinal survey of 2736 community-dwelling men aged 40-79 years at baseline recruited from eight centres across Europe. Follow-up assessment occurred mean (GS.D.) 4.4G0.3 years later. Results: Paired testosterone results were available for 2395 men. Mean (GS.D.) annualised hormone changes were as follows: testosterone K0.1G0.95 nmol/l; free testosterone (FT) K3.83 G16.8 pmol/l; sex hormone-binding globulin (SHBG) 0.56G2.5 nmol/l and LH 0.08G0.57 U/l. Weight loss was associated with a proportional increase, and weight gain a proportional decrease, in testosterone and SHBG. FT showed a curvilinear relationship to weight change; only those who gained or lost R15% of weight showed a significant change (in the same direction as testosterone). Smoking cessation was associated with a greater decline in testosterone than being a non-smoker, which was unrelated to weight change. Changes in number of comorbid conditions or physical activity were not associated with significant alterations in hypothalamic-pituitary-testicular (HPT) axis function. Conclusions: Body weight and lifestyle factors influence HPT axis function in ageing. Weight loss was associated with a rise, and weight gain a fall, in testosterone, FT and SHBG. Weight management appears to be important in maintaining circulating testosterone in ageing men, and obesity-associated changes in HPT axis hormones are reversible following weight reduction.

show abstract

Sex Hormone-Binding Globulin as an Independent Predictor of Incident Type 2 Diabetes Mellitus in Men

Cited by 81 publications

References 53 publications

The biomarker sex hormone-binding globulin – From established applications to emerging trends in clinical medicine

The biomarker sex hormone-binding globulin – From established applications to emerging trends in clinical medicine

Sex hormone–binding globulin and risk of hyperglycemia in patients with androgenetic alopecia

Age-associated changes in hypothalamic–pituitary–testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study

Contact Info

Product

Resources

About