Sex-Endocrine Factors in Blood and Urine in Health and Disease

Frank, Robert T.

doi:10.1001/jama.1935.92760220004013

JAMA

1935

DOI: 10.1001/jama.1935.92760220004013

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Sex-Endocrine Factors in Blood and Urine in Health and Disease

Robert T. Frank¹

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1936

1941

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Cited by 25 publications

References 39 publications

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Factors Influencing Retention of Nitrogen and Calcium in Period of Growth

Johnston¹

1941

Am J Dis Child

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Puberty in the girl was shown in a previous communication1 to be associated with a fall in the retention of calcium and nitrogen, a fact which might be anticipated if one recalls the prompt diminution in the rate of growth associated with the attainment of sexual maturity. The phenomena of a rapid increase in the rate of growth preceding puberty and the fall following it have been shown to correlate with physiologic and not with chronologic age. It has likewise been shown that there is a rise in the basal metabolic rate associated with the increasing rate of growth and the increasing retention of calcium and nitrogen and a fall in the metabolic rate coincident with the diminishing retention of these two substances; in other words, changes in the metabolic rate paralleled directly, rather than inversely, the retentions of calcium and nitrogen, though an inverse relation might have been expected from the result of work on the effects of thyroid on adults. The present inquiry was planned to study the effect of estrogenic substance on the retention of these substances in the girl at puberty.Katzman and Doisy2 have demonstrated that there is a cyclic excretion of estrogenic substance even before the onset of menstruation, and in the blood of the normally menstruating woman Frank3 has described a gradual increase in the excretion of this substance in the week just preceding the onset of the flow and a sharp disappearance two to six hours after the onset of the flow.

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Factors Influencing Retention of Nitrogen and Calcium in Period of Growth

Johnston¹

1941

Am J Dis Child

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Endocrine Factors in Sterility

Chute¹

1936

JAMA

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Gonadotropic Hormone in the Blood and Urine of Early Pregnancy

Evans¹

1937

JAMA

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Sex-Endocrine Factors in Blood and Urine in Health and Disease

Cited by 25 publications

References 39 publications

Factors Influencing Retention of Nitrogen and Calcium in Period of Growth

Factors Influencing Retention of Nitrogen and Calcium in Period of Growth

Endocrine Factors in Sterility

Gonadotropic Hormone in the Blood and Urine of Early Pregnancy

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