Sex Dimorphism in the Relation between Early Adiposity and Cardiometabolic Risk in Adolescents

Huang, Rae‐Chi; Mori, Trevor A.; Burrows, Sally; Le-Ha, Chi; Oddy, Wendy H.; Herbison, Carly E.; Hands, B.; Beilin, Lawrence J.

doi:10.1210/jc.2011-3007

Cited by 37 publications

(51 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Meta-analysis has shown that obese children compared to their normal weight peers are 3-5 times more prone to hypertension [38]. Obesity is a stronger risk factor for HT in teenage boys than girls [39]. These observations are in agreements with our results, because the blood pressure ≥ c95 was seen in over 16% of the study population.…”

Section: Discussionsupporting

confidence: 92%

“…Obesity in children is still not considered a factor contributing to the development of many metabolic diseases in the future. An important factor responsible for eating disorders in children is the lack of knowledge about the factors contributing to the health of children [39,46]. These observations are supported by the findings in the population ZG and LE.…”

Section: Discussionsupporting

confidence: 67%

See 1 more Smart Citation

The incidence of some components of the metabolic syndrome in children in medium sized town and rural area in Poland

Głowacka

Sawer-Szewczyk

Drzewoski

et al. 2018

Clinical Diabetology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 67%

The incidence of some components of the metabolic syndrome in children in medium sized town and rural area in Poland

Głowacka

Sawer-Szewczyk

Drzewoski

et al. 2018

Clinical Diabetology

View full text Add to dashboard Cite

“…Detailed information on measures of blood pressure, anthropometry and biochemistry, is given in detail elsewhere [23,24]. Briefly, blood pressure was measured with an automatic device (Dinamap Vital Signs Monitor 8100, Dinamap XL Vital Signs Monitor or Dinamap ProCare 100; GE Healthcare) after 5 minutes rest and using the appropriate cuff size.…”

Section: Blood Pressure Anthropometry and Blood Samplesmentioning

confidence: 99%

“…Six readings were recorded, and the average value was calculated after excluding the first reading. at Royal Perth Hospital as described previously [23,24].…”

Section: Blood Pressure Anthropometry and Blood Samplesmentioning

confidence: 99%

See 1 more Smart Citation

Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22

Løset

Johnson

Melton

et al. 2014

Pregnancy Hypertension: An International Journal of Women's Car

Self Cite

View full text Add to dashboard Cite

Objective: Four putative single nucleotide polymorphism (SNP) risk variants at the preeclampsia susceptibility locus on chromosome 2q22; rs2322659 (LCT), rs35821928 (LRP1B), rs115015150 (RND3) and rs17783344 (GCA), were recently shown to associate with known cardiovascular risk factors in a Mexican American cohort. This study aimed to further evaluate the pleiotropic effects of these preeclampsia risk variants in an independent Australian population-based cohort. Methods:The four SNPs were genotyped in the Western Australian Pregnancy Cohort (Raine) Study that included DNA, clinical and biochemical data from 1,246 mothers and 1,404 of their now adolescent offspring. Genotype association analyses were undertaken using the SOLAR software.Results: Nominal associations (P < 0.05) with cardiovascular risk factors were detected for all four SNPs. The LCT SNP was associated with decreased maternal height (P = 0.005) and decreased blood glucose levels in adolescents (P = 0.022). The LRP1B SNP was associated with increased maternal height (P = 0.026) and decreased maternal weight (P = 0.044). The RND3 SNP was associated with decreased triglycerides in adolescents (P = 0.001). The GCA SNP was associated with lower risk in adolescents to be born of a preeclamptic pregnancy (P = 0.003) and having a mother with prior preeclamptic pregnancy (P = 0.033). Conclusions:Our collective findings support the hypothesis that genetic mechanisms for preeclampsia and CVD are, at least in part, shared, but need to be interpreted with some caution as a Bonferroni correction for multiple testing adjusted the statistical significance threshold (adjusted P < 0.001).

show abstract

Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents

et al. 2013

Self Cite

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is regarded as the hepatic manifestation of the metabolic syndrome. In adults, NAFLD is a determinant of arterial stiffness and cardiovascular risk, independent of the metabolic syndrome. Our aim was to ascertain if NAFLD is associated with arterial stiffness, independent of cardiometabolic factors in a population-based cohort of adolescents. The 17-year-olds (n 5 964) from an Australian birth cohort had measures of anthropometry, blood pressure, fasting insulin, glucose, lipids, and NAFLD by ultrasound. Two-step cluster analysis identified youth at high metabolic risk. Measures of arterial stiffness (pulse wave velocity [PWV] and augmentation index corrected for heart rate [AI@75]) were obtained using applanation tonometry. The overall prevalence of NAFLD was 13.3%. The "high risk" metabolic cluster at age 17 years included 16% males and 19% females. Compared to "low risk," the "high risk" cluster participants had greater waist circumference, triglycerides, insulin, systolic blood pressure, and lower high-density lipoprotein (HDL) cholesterol (all P < 0.0001). Those who had NAFLD but were not in the "high risk" metabolic cluster did not have increased PWV or AI@75. However, males and females who had NAFLD in the presence of the metabolic cluster had greater PWV (b 5 0.20, 95% confidence interval [CI] 0.01 to 0.38, P 5 0.037). Males who had NAFLD in the presence of the metabolic cluster had greater AI@75 (b 5 6.3, 95% CI 1.9 to 10.7, P 5 0.005). Conclusion: NAFLD is only associated with increased arterial stiffness in the presence of the "high risk" metabolic cluster. This suggests that arterial stiffness related to the presence of NAFLD is predicated on the presence of an adverse metabolic profile in adolescents. (HEPATOLOGY 2013;58:1306-1314 N onalcoholic fatty liver disease (NAFLD) is the most prevalent liver condition worldwide, affecting between 15%-30% of adults and 13%-18% of adolescents.1,2 The development of NAFLD is intimately related to key components of the metabolic syndrome, namely, central obesity, disturbed lipid metabolism, and insulin resistance. Thus, NAFLD has been considered the hepatic component of the metabolic syndrome.3 As the metabolic syndrome is a cluster of factors that predict cardiovascular disease (CVD), it is not surprising that CVD is the leading cause of death in patients with NAFLD, accounting for 30% of all deaths. 4,5 In contrast, only a small proportion of subjects with NAFLD develop cirrhosis or die from complications of their liver disease.Abbreviations: AI@75, augmentation index corrected for heart rate; AIx, aortic augmentation index; CVD, cardiovascular disease; HOMA-IR, homeostasis model for insulin resistance; hsCRP, high sensitivity C-reactive protein; NAFLD, nonalcoholic fatty liver disease; PWC 170 , physical work capacity at a heart rate of 170 beats per minute; PWV, pulse wave velocity.From the

show abstract

Sex Dimorphism in the Relation between Early Adiposity and Cardiometabolic Risk in Adolescents

Cited by 37 publications

References 37 publications

The incidence of some components of the metabolic syndrome in children in medium sized town and rural area in Poland

The incidence of some components of the metabolic syndrome in children in medium sized town and rural area in Poland

Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22

Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents

Contact Info

Product

Resources

About