Sex‐differentiated associations among negative parenting, emotion‐related brain function, and adolescent substance use and psychopathology symptoms

Chaplin, Tara M.; Poon, Jennifer A.; Thompson, James C.; Hansen, Amysue; Dziura, Sarah L.; Turpyn, Caitlin C.; Niehaus, Claire E.; Sinha, Rajita; Chassin, Laurie; Ansell, Emily B.

doi:10.1111/sode.12364

Cited by 28 publications

(26 citation statements)

References 69 publications

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“…First, it may be that certain individuals experience heightened negative emotion from losing and drink alcohol to downregulate this negative emotion. This is consistent with research linking increased neural activation in emotion processing regions—amygdala, insula, and anterior cingulate cortex—to increased substance use in adolescents ( Chaplin et al, 2019 ; Spechler et al, 2015 ) and young adults ( Nikolova et al, 2016 ; Ray et al, 2010 ). Alternatively, individuals may experience “numbness” or blunted emotion in response to loss that may cause them to upregulate by drinking alcohol ( Heitzeg et al, 2008 ; Yip et al, 2016 ).…”

Section: Introductionsupporting

confidence: 88%

Neural activation to loss and reward among alcohol naive adolescents who later initiate alcohol use

Gonçalves

Turpyn

Niehaus

et al. 2021

Developmental Cognitive Neuroscience

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Adolescent alcohol use is associated with adverse psychosocial outcomes, including an increased risk of alcohol use disorder in adulthood. It is therefore important to identify risk factors of alcohol initiation in adolescence. Research to date has shown that altered neural activation to reward is associated with alcohol use in adolescence; however, few studies have focused on neural activation to loss and alcohol use. The current study examined neural activation to loss and reward among 64 alcohol naive 12−14 year olds that did ( n = 20) and did not initiate alcohol use by a three year follow-up period. Results showed that compared to adolescents that did not initiate alcohol use, adolescents that did initiate alcohol use by the three year follow-up period had increased activation to loss in the left striatum (i.e., putamen), right precuneus, and the brainstem/pons when they were alcohol naive at baseline. By contrast, alcohol initiation was not associated with neural activation to winning a reward. These results suggest that increased activation in brain regions implicated in salience, error detection/self-referential processing, and sensorimotor function, especially to negative outcomes, may represent an initial vulnerability factor for alcohol use in adolescence.

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Section: Introductionsupporting

confidence: 88%

Neural activation to loss and reward among alcohol naive adolescents who later initiate alcohol use

Gonçalves

Turpyn

Niehaus

et al. 2021

Developmental Cognitive Neuroscience

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“…A small, but growing number of neuroimaging studies focused on identifying associations between parental emotion expression and activation within neural networks supporting salience detection and other ER subprocesses in children and adolescents. For example, using negative emotional pictures, two fMRI studies of adolescents found that higher levels of maternal negative emotion were related to greater neural activation in brain regions implicated in detecting (e.g., amygdala, anterior insula) and regulating (e.g., ACC, vlPFC) emotions (Chaplin et al, 2019; Turpyn, Poon, Ross, Thompson, & Chaplin, 2018). These findings are similar to those from studies of negative parenting; however, some researchers have suggested that associations differ for boys and girls, a potential sex moderator requiring further investigation.…”

Section: Part 2: Parental Emotion Socialization and Er Neural Networkmentioning

confidence: 99%

“…For example, one study found that higher levels of maternal negative emotion were associated with greater right rACC activation for girls, but reduced activation for boys. Moreover, for girls only, elevated rACC activation was associated with more depressive symptoms (Chaplin et al, 2019). These results highlight the need to consider the sex of both child and parent in future research.…”

Section: Part 2: Parental Emotion Socialization and Er Neural Networkmentioning

confidence: 99%

A review of associations between parental emotion socialization behaviors and the neural substrates of emotional reactivity and regulation in youth.

Tan¹,

Oppenheimer

Ladouceur

et al. 2020

Developmental Psychology

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As highlighted by Eisenberg, Cumberland, and Spinrad (1998), parents play a critical role in children’s socioemotional development, in part, by shaping how children and adolescents process, respond to, and regulate their emotions (i.e., emotional reactivity/regulation). Although evidence for associations between parenting behavior and youth’s emotional processing has relied primarily on behavioral measures of emotion, researchers have begun to examine how parenting is related to the neural substrates of youth’s reactivity and regulation. This article reviews a growing literature linking parental behavior with structural brain development as well as functional activity and connectivity in neural regions supporting emotional reactivity/regulation during infancy, childhood, and adolescence. By focusing on normative parental behaviors, we evaluate the evidence for associations between typical variations in caregiving and neural processes thought to support youth’s emotional reactivity/regulation. The purpose of this review is to (1) extend the model put forth by Eisenberg and colleagues to consider the ways that parenting behaviors are related to neural substrates of youth’s emotional reactivity and regulation; (2) review the empirical evidence for associations between parenting, particularly parental “emotion-related socialization behaviors” (ERSBs), and neural substrates of youth’s emotional reactivity/regulation; and (3) recommend future directions for this emerging area of research.

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“…With respect to stress acceleration, six studies on negative parenting behaviors, maternal depressive symptoms, and parental substance were in line with this model (Chaplin et al, 2019; Heitzeg et al, 2008; Heitzeg et al, 2010; Hulvershorn et al, 2013; Kwon et al, 2021; Wang et al, 2020). In the study examining parenting behavior, a mediation model was not conducted, as there were no significant associations between brain function and externalizing behavior.…”

Section: Discussionmentioning

confidence: 61%

“…The threat-based dimensional model was supported across nine reviewed studies, such that corporal punishment, negative parenting behaviors, maternal depressive symptoms, and parental history of substance use led to disruptions (i.e., smaller volumes, lower frontal and higher limbic activation) in frontolimbic regions (Andre et al, 2020b; Barbosa et al, 2018; Chaplin et al, 2019; Heitzeg et al, 2008; Heitzeg et al, 2010; Heitzeg et al, 2014; Qu et al, 2016; Venkatasubramanian et al, 2007; Wang et al, 2020). The proposed mediation model was not supported in studies assessing for corporal punishment, negative parenting, and parental substance use.…”

Section: Discussionmentioning

confidence: 92%

Parental Deprivation- and Threat-Based Factors Associated with Youth Emotion-Based Neurocircuitry and Externalizing Behavior: A Systematic Review

Feeney

Lobo

Hare

et al. 2022

Preprint

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Parental factors, including negative parenting practices (e.g., family conflict, low monitoring), parental depression, and parental substance use, are associated with externalizing behaviors in youth; however, the mediating role of youth's neurocircuitry in explaining these associations has been less studied. Both the dimensional and stress acceleration models provide frameworks for understanding how frontolimbic and frontoparietal networks implicated in emotional attention and regulation processes may be associated with parental factors. The current review builds upon this work by examining how deprivation- and threat-based parental factors are associated with youth externalizing behaviors through youth neurocircuitry involved in emotional functioning. A systematic review using PRISMA guidelines was completed and included five studies assessing parenting behaviors, six studies assessing parental depressive symptoms and/or diagnosis, and 12 studies assessing parental history of substance use. Overall, reviewed studies provided support for the dimensional and stress acceleration models within the context of deprivation and threat. There was limited support for the proposed mediation model, as only six studies tested for mediation. Specific recommendations for future work include more deliberate planning related to sample composition, improved clarity related to parental constructs, and consistency in methodology in order to better understand associations between contextual parental influences and youth neural and behavioral functioning.

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Sex‐differentiated associations among negative parenting, emotion‐related brain function, and adolescent substance use and psychopathology symptoms

Cited by 28 publications

References 69 publications

Neural activation to loss and reward among alcohol naive adolescents who later initiate alcohol use

Neural activation to loss and reward among alcohol naive adolescents who later initiate alcohol use

A review of associations between parental emotion socialization behaviors and the neural substrates of emotional reactivity and regulation in youth.

Parental Deprivation- and Threat-Based Factors Associated with Youth Emotion-Based Neurocircuitry and Externalizing Behavior: A Systematic Review

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