Sex differential effect of dexmedetomidine on fear memory extinction and anxiety behavior in adolescent rats

Jang, Minji; Jung, Taesub; Kim, Sung Hoon; Noh, Jihyun

doi:10.1016/j.neures.2019.01.006

Cited by 16 publications

(10 citation statements)

References 37 publications

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“…However, the effect of dextromethopyrimidine might be different between the sexes. Jang et al ( 32 ) analyzed and found that dexmedetomidine accelerated the extinction of fear memory and reduced anxiety in rats, but it was more effective on female rats than male rats. Li et al ( 33 ) reported that the effect of dexmedetomidine on acute postoperative pain in male patients is better than that in female patients.…”

Section: Discussionmentioning

confidence: 99%

Application of dexmedetomidine-assisted intravertebral anesthesia in hip replacement and its influence on T-lymphocyte subsets

2020

Exp Ther Med

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A�� -�� -A�� -�� -��b�� h�� y �� w��h h�� its influences on T-lymphocyte subsets in peripheral blood were assessed. Eighty-six patients undergoing intravertebral anesthesia in hip replacement were treated as group A, and one hundred patients undergoing intravertebral anesthesia combined with dexmedetomidine were treated as group B. Hemodynamic changes in both groups were compared 5 min b�� h�� (T0), ��y �� k�� (T1) and after surgery (T2). General operation conditions of patients in both groups were recorded. T-lymphocyte subsets, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), visual analogue scale (VAS) pain scores and mini-mental state examination (MMSE) cognitive function changes before surgery and 24 h after surgery were compared between the groups, and the incidence of complications in both groups after 24 h was recorded. The recovery time of patients in group B was shorter than that of group A (P<0.05). Changes of systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate fluctuations in group B were lower than those in group A (P<0.05). At 24 h after surgery, VAS scores of group B were lower than those of group A (P<0.05); levels of IL-6 and TNF-α were lower than those of group A (P<0.05); CD3 + ��, CD4 + ��, CD8 + cells, and CD4/CD8 ratio were higher than those of group A (P<0.05), and MMSE score was higher than that of group A (P<0.05). The incidence of gastrointestinal reactions and postoperative cognitive dysfunction (POCD) in group B was lower than that in group A (P<0.05). In conclu-��, �� y �h�� h� ��y �� , ��b��z� �� hemodynamics of patients, protect immune function, and reduce postoperative pain and POCD occurrence during anes-�h�� h�� .

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Section: Discussionmentioning

confidence: 99%

Application of dexmedetomidine-assisted intravertebral anesthesia in hip replacement and its influence on T-lymphocyte subsets

2020

Exp Ther Med

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“…The large body of behavioral work on acquisition of aversive fear conditioning in rodent models has shown that most commonly-used inhalational anesthetics and intravenous sedative-hypnotic agents (particularly propofol, midazolam, and ketamine) inhibit fear learning at higher doses [29]. Perhaps not surprisingly, dexmedetomidine appears to be an outlier, with no significant inhibition of fear learning [29], but it could enhance extinction of acquired fear [30]. Opioids likely also play a role, as fear conditioning is inhibited by morphine [31] and enhanced by opioid antagonists in rodents [32,33].…”

Section: Anesthetic Modulation Of Fear Acquisiitionmentioning

confidence: 99%

Anesthesia and the neurobiology of fear and posttraumatic stress disorder

Vogt

Pryor

2022

Current Opinion in Anaesthesiology

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Purpose of reviewDysfunction of fear memory systems underlie a cluster of clinically important and highly prevalent psychological morbidities seen in perioperative and critical care patients, most archetypally posttraumatic stress disorder (PTSD). Several sedative-hypnotics and analgesics are known to modulate fear systems, and it is theoretically plausible that clinical decisions of the anesthesiologist could impact psychological outcomes. This review aims to provide a focused synthesis of relevant literature from multiple fields of research.Recent findingsThere is evidence in some contexts that unconscious fear memory systems are less sensitive to anesthetics than are conscious memory systems. Opiates may suppress the activation of fear systems and have benefit in the prevention of PTSD following trauma. There is inconsistent evidence that the use of propofol and benzodiazepines for sedation following trauma may potentiate the development of PTSD relative to other drugs. The benefits of ketamine seen in the treatment of major depression are not clearly replicated in PTSD-cluster psychopathologies, and its effects on fear processes are complex.SummaryThere are multiple theoretical mechanisms by which anesthetic drugs can modulate fear systems and clinically important fear-based psychopathologies. The current state of research provides some evidence to support further hypothesis investigation. However, the absence of effectiveness studies and the inconsistent signals from smaller studies provide insufficient evidence to currently offer firm clinical guidance.

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“…Dexmedetomidine (DEX) is a medication clinically used as an anesthetic, sedative, and anxiolytic medication 17 . It works by activating the α__2-adrenergic receptors, which can help to relieve pain and reduce the activity of the sympathetic nervous system.…”

Section: Introductionmentioning

confidence: 99%

Stabilized two-photon intravital imaging using dexmedetomidine

Kim¹,

Cho²,

Paulson³

et al. 2023

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI

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Two-photon microscopy provides subcellular-resolution imaging deep into animal tissues, and is frequently used for the study of biological and disease processes. However, its applicability in vivo is complicated by physiological movement. We demonstrate treatment with dexmedetomidine (DEX), an already FDA-approved alpha-2 adrenergic receptor agonist, to reduce tissue oscillation frequency and amplitude in the livers of anesthetized mice. Fluorescence intensity and focal quality fluctuations were found to improve for 30 minutes after administration, indicating that dexmedetomidine may be used to improve imaging quality in two-photon intravital microscopy studies. These results will likely generalize to other imaging modalities, target tissues, and animal models.

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Sex differential effect of dexmedetomidine on fear memory extinction and anxiety behavior in adolescent rats

Cited by 16 publications

References 37 publications

Application of dexmedetomidine-assisted intravertebral anesthesia in hip replacement and its influence on T-lymphocyte subsets

Application of dexmedetomidine-assisted intravertebral anesthesia in hip replacement and its influence on T-lymphocyte subsets

Anesthesia and the neurobiology of fear and posttraumatic stress disorder

Stabilized two-photon intravital imaging using dexmedetomidine

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