Sex differences in the subjective and reinforcing effects of cigarette nicotine dose

Perkins, Kenneth A.; Jacobs, Lynette; Sanders, Mark H.; Caggiula, Anthony R.

doi:10.1007/s00213-002-1168-1

Cited by 130 publications

(115 citation statements)

References 23 publications

(29 reference statements)

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“…The possibility that there may be sex differences in the contribution of nicotine and non-nicotine factors to smoking is supported by clinical outcomes which suggest that smoking may be less strongly driven by the direct effects of nicotine for women than men Perkins et al 2002). Conversely, female smokers appear to show greater sensitivity than males to nonpharmacological stimuli that are associated with cigarette use .…”

Section: Future Directionsmentioning

confidence: 99%

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement

et al. 2005

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Although considerable progress has been made we do not yet fully understand the behavioral and neurobiological bases of nicotine reinforcement, and without this knowledge treatment strategies aimed at reducing smoking remain deficient. This dissertation provides an original perspective on nicotine reinforcement, which arises from substantial evidence of complex interactions between nicotine and nonpharmacological stimuli. The present experiments tested the hypothesis that nicotine reinforcement derives from at least two sources: 1) the primary reinforcing properties of nicotine, an action that requires response-dependent drug administration, and 2) the more prominent ability of nicotine to enhance behavior maintained by salient non-nicotine stimuli, an action that does not require a contingent relationship between drug administration and reinforced operant responding. Although novel for nicotine, this hypothesis has origins in an extensive literature on the reinforcing properties of psychostimulant drugs. Empirical support for the application of this hypothesis to nicotine reinforcement will be presented. By investigating the interaction between nicotine and nonpharmacological stimuli within the context of drug selfadministration in rats, the present research has generated new insights into the paradox of how nicotine, an apparently weak primary reinforcer, can sustain the robust behavior observed in selfadministration and in smoking. Hypotheses generated by these data provide important direction for future investigations into the neurobiology of nicotine reinforcement.iii

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Section: Future Directionsmentioning

confidence: 99%

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement

et al. 2005

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“…differences related to smoking (see Perkins, 2001 for review), women derive more pleasure from the smell and taste of cigarettes (Perkins et al, , 2002, have a stronger motivation to use nicotine to avoid or reduce negative affect (Hogle and Curtin, 2006), and are more likely to smoke to control their body weight (Levine et al, 2006;Perkins, 2001). In fact, relapse often occurs because of concerns with postcessation weight gain (Levine et al, 2006).…”

mentioning

confidence: 99%

Effects of Cigarette Smoking and Family History of Alcoholism on Sweet Taste Perception and Food Cravings in Women

Pepino

Mennella

2007

Alcoholism Clin & Exp Res

113

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“…These include gender differences in nicotine metabolism [24], that women are influenced less by nicotine and more by non-nicotine factors [25], and that there is a gender difference in fear of or reactions to post-cessation weight gain [26], or post-cessation depression [27]. The present data cannot exclude such explanations.…”

Section: Discussionmentioning

confidence: 77%

Smoking Cessation Treatment Outcomes in Men and Women in Taiwan: Implications for Interpreting Gender Differences in Smoking Cessation

Hsueh¹,

Hsueh²,

Chou³

et al. 2013

TOADDJ

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Several clinical trials of both behavioural and pharmacological treatments across Europe and the US have reported lower smoking cessation rates in women than in men, while population data and data from smokers attending routine stop-smoking services show little or no gender differences in outcome. Data from countries with a large gender difference in smoking prevalence can clarify whether self-selection could be responsible for this discrepancy. We analyzed data from a smoking cessation clinic in Taiwan, where 47% of men and 4% of women smoke. 1,090 smokers (963 men and 127 women) seeking help at a Taiwanese smokers' clinic between 2002 and 2007 received nicotine patches and up to 8 support sessions. Several baseline variables were collected together with self-reported smoking status at 3 and 6 months. Sustained abstinence rates (abstinent at both 3 months and 6 months) were significantly lower in women than in men (18.0% vs 30.3%, p=0.04), as were point-prevalence abstinence rates at both 3 (28.3% vs 38.5%, p=0.026) and 6 months (22.0% vs 35.0%, p=0.004). In a multiple regression including all baseline variables, only gender and cigarettes per day were significant predictors of sustained abstinence. In conclusion, among a cohort of treatment-seekers in Taiwan, there was a significant gender difference in smoking cessation outcomes. Given that such an effect is small or non-existent in countries where the prevalence of smoking across genders is similar, this suggests that sporadic gender differences could be an artifact of self-selection.

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Sex differences in the subjective and reinforcing effects of cigarette nicotine dose

Abstract: These results indicate that cigarette nicotine dose is a less important influence on the subjective and, under some conditions, reinforcing effects of smoking in women than in men.

Cited by 130 publications

References 23 publications

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement

Effects of Cigarette Smoking and Family History of Alcoholism on Sweet Taste Perception and Food Cravings in Women

Smoking Cessation Treatment Outcomes in Men and Women in Taiwan: Implications for Interpreting Gender Differences in Smoking Cessation

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