Sex Differences in the Residual Patellar Tendon After Harvesting Its Central Third for Anterior Cruciate Ligament Reconstruction

Kanamoto, Takashi; Tanaka, Yoshinari; Yonetani, Yasukazu; Kita, Keisuke; Amano, Hiroshi; Okamoto, Kensuke; Shino, Konsei; Horibe, Shuji

doi:10.1002/jum.14419

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…We also hypothesized that the effect of aging on the ability of tendon explants to respond to stress deprivation may be sexdependent based on recent studies describing differential healing based on sex. [34][35][36]…”

Section: Introductionmentioning

confidence: 99%

Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent

Connizzo

Piet

Shefelbine

et al. 2019

Connective Tissue Research

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The incidence of tendon injuries increases dramatically with age, which presents a major clinical burden. While previous studies have sought to identify age-related changes in extracellular matrix structure and function, few have been able to explain fully why aged tissues are more prone to degeneration and injury. In addition, recent studies have also demonstrated that age-related processes in humans may be sex-dependent, which could be responsible for muddled conclusions in changes with age. In this study, we investigate short-term responses through an ex vivo explant culture model of stress deprivation that specifically questions how age and sex differentially affect the ability of tendons to respond to altered mechanical stimulus. We subjected murine flexor explants from young (4 months of age) and aged (22-24 months of age) male and female mice to stress-deprived culture conditions for up to one week and investigated changes in viability, cell metabolism and proliferation, matrix biosynthesis and composition, gene expression, and inflammatory responses throughout the culture period. We found that aging did have a significant influence on the response to stress deprivation, demonstrating that aged explants have a less robust response overall with reduced metabolic activity, viability, proliferation, and biosynthesis. However, age-related changes appeared to be sex-dependent. Together, this work demonstrates that the aging process and the subsequent effect of age on the ability of tendons to respond to stressdeprivation are inherently different based on sex, where male explants favor increased activity,

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Section: Introductionmentioning

confidence: 99%

Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent

Connizzo

Piet

Shefelbine

et al. 2019

Connective Tissue Research

View full text Add to dashboard Cite

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Changes in patellar height after anatomical ACL reconstruction with BTB autograft with a focus on patellar tendon removal volume

Kanamoto

Tanaka

Yonetani

et al. 2023

Journal of Orthopaedic Science

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Effect of Graft Type on Thigh Circumference, Knee Range of Motion, and Lower-Extremity Strength in Pediatric and Adolescent Males Following Anterior Cruciate Ligament Reconstruction

Sugimoto¹,

Heyworth²,

Yates³

et al. 2020

Journal of Sport Rehabilitation

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Context: To treat anterior cruciate ligament (ACL) injury, ACL reconstruction (ACLR) surgery is currently a standard of the care. However, effect of graft type including bone–patellar tendon–bone (BTB), hamstring tendon, or iliotibial band (ITB) on thigh size, knee range of motion (ROM), and muscle strength are understudied. Objective: To compare postoperative thigh circumference, knee ROM, and hip and thigh muscle strength in adolescent males who underwent ACLR, based on the 3 different autograft types: BTB, hamstring (HS), and ITB. Setting: Biomechanical laboratory. Participants: Male ACLR patients who are younger than 22 years of age (total N = 164). Intervention: At 6- to 9-month postoperative visits, thigh circumference, knee ROM, and hip and thigh muscle strength were measured. Main Outcome Measures: Deficits of each variable between the uninvolved and ACLR limb were compared for pediatric and adolescent ACLR males in the BTB, HS, and ITB cohorts. Baseline characteristics, including physical demographics and meniscus tear status, were compared, and differences identified were treated as covariates and incorporated in analysis of covariance. Results: Data were from 164 adolescent male ACLR patients [mean age 15.7 (1.2) years]. There were no statistical differences in thigh circumference, knee ROM, hip abductor, and hip-extensor strength among the 3 autografts. However, patients with BTB demonstrated 12.2% deficits in quadriceps strength compared with 0.5% surplus in HS patients (P = .002) and 1.2% deficits in ITB patients (P = .03). Patients with HS showed 31.7% deficits in hamstring strength compared with 5.4% deficits in BTB (P = .001) and 7.7% deficits in ITB (P = .001) groups at 6- to 9-month postoperative visits. Conclusion: Adolescent male ACLR patients with BTB and HS autografts demonstrated significant deficits in quadriceps and hamstring strength, respectively, at 6 to 9 months postoperatively. Minimal lower-extremity strength deficits were demonstrated in pediatric male ACLR patients undergoing ITB harvest.

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Sex Differences in the Residual Patellar Tendon After Harvesting Its Central Third for Anterior Cruciate Ligament Reconstruction

Cited by 3 publications

References 35 publications

Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent

Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent

Changes in patellar height after anatomical ACL reconstruction with BTB autograft with a focus on patellar tendon removal volume

Effect of Graft Type on Thigh Circumference, Knee Range of Motion, and Lower-Extremity Strength in Pediatric and Adolescent Males Following Anterior Cruciate Ligament Reconstruction

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