Sex differences in the regulation of hepatic mitochondrial turnover following physical activity: do males need more quality control than females?

Bellissimo, Catherine A.; Perry, Christopher G. R.

doi:10.1113/jp276896

Cited by 2 publications

(1 citation statement)

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“…In general, females exhibited an improved mitochondrial quality than males. Men often need to exercise to maintain a stronger mitochondrial respiratory function, whereas women can maintain this function even without exercise[ 52 ]. A recent study reported a close relationship between liver pyruvate kinase (LPK) and NAFLD.…”

Section: Influencing Factorsmentioning

confidence: 99%

Nonalcoholic fatty liver disease shows significant sex dimorphism

Chen¹,

Huang²,

Zhang³

2022

WJCC

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Nonalcoholic fatty liver disease (NAFLD), which has been renamed metabolic dysfunction-associated fatty liver disease, is a growing global medical problem. The incidence of NAFLD and its associated end-stage liver disease is increasing each year, and many research advancements have been achieved to date. This review focuses on the current knowledge of the sex differences in NAFLD and does not elaborate on areas without differences. Studies have revealed significant sex differences in the prevalence, influencing factors, pathophysiology, complications and therapies of NAFLD. Men have a higher incidence than women. Compared with women, men exhibit increased visceral fat deposition, are more susceptible to leptin resistance, lack estrogen receptors, and tend to synthesize fatty acids into fat storage. Male patients will experience more severe hepatic fibrosis and a higher incidence of liver cancer. However, once NAFLD occurs, women show a faster progression of liver fibrosis, higher levels of liver cell damage and inflammation and are less likely to undergo liver transplantation than men. In general, men have more risk factors and more severe pathophysiological reactions than women, whereas the development of NAFLD is faster in women, and the treatments for women are more limited than those for men. Thus, whether sex differences should be considered in the individualized prevention and treatment of NAFLD in the future is worth considering.

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Section: Influencing Factorsmentioning

confidence: 99%