Abstract:Insulin, an important regulator of peripheral metabolism, has been reported to interact with many neurotransmitter systems including those associated with convulsion. The effect of insulin against pentylenetetrazole and strychnine-induced convulsions in mice, as well as possible sex differences, were evaluated in this study. Mice of both sexes weighing between 20 and 25 g were administered insulin intraperitoneally at doses of 1, 2, 4 and 8 IU/kg. Each mouse received a convulsive dose of pentylenetetrazole (10… Show more
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