Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection

Mikerov, Anatoly N.; Gan, Xiaozhuang; Umstead, Todd M.; Miller, Laura C.; Chinchilli, Vernon M.; Phelps, David S.; Floros, Joanna

doi:10.1186/1465-9921-9-24

Cited by 68 publications

(182 citation statements)

References 51 publications

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“…A recent study by Mikerov and coworkers reported that male mice were more susceptible than female mice to lung infection with Klebsiella pneumoniae but that this pattern was reversed in mice that had been exposed to ozone before establishment of the infection (30). Tissue damage associated with carrageenan-induced pleurisy in rats was reported to be attenuated by estrogen; this effect was blocked by coadministration of the ER antagonists ICI 182780 or tamoxifen, suggestive of a receptor-mediated effect (31).…”

Section: Nonallergic Lung Inflammation and Acute Lung Injurymentioning

confidence: 99%

Hormonal Influences on Lung Function and Response to Environmental Agents: Lessons from Animal Models of Respiratory Disease

Card¹,

Zeldin²

2009

Proceedings of the American Thoracic Society

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Numerous studies in humans and experimental animals have identified considerable sex differences in respiratory physiology and in the response of the lung to environmental agents. These differences appear to be mediated, at least in part, by sex hormones and their nuclear receptors. Moreover, animal models are increasingly used to study pathogenic mechanisms and test potential therapies for a variety of human lung diseases, many of which appear to be influenced by sex and sex hormones. In this article, data are summarized from studies of lung function and disease in which sex differences have been observed. Specific attention is paid to animal models of acute lung injury, nonallergic and allergic lung inflammation, and lung fibrosis. It is anticipated that continued investigation of the role of sex and sex hormones in animal models will provide valuable insight into the pathogenesis and potential treatments for a variety of acute and chronic human lung diseases.

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Section: Nonallergic Lung Inflammation and Acute Lung Injurymentioning

confidence: 99%

Hormonal Influences on Lung Function and Response to Environmental Agents: Lessons from Animal Models of Respiratory Disease

Card¹,

Zeldin²

2009

Proceedings of the American Thoracic Society

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“…Akciğer hastalıklarının insidans ve ağırlığını inceleyen hayvan çalışmaları da bu sonucu desteklemektedir. Yeni bir hayvan çalışmasında da kadın seks hormonlarının akciğer hastalıklarına karşı koruyucu etkisi gösterilmiştir 4,5 .…”

Section: şEkil 2 Olgu 5 Toraks Tomografisiunclassified

Daptomisin alan hastalarda gelişen ani solunum yetmezliği ve eozinofilik pnömoni: beş olgunun sunumu

Kömür¹,

Ulu²,

Kurtaran³

et al. 2016

Cukurova Med J

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AbstractÖz Daptomycin is the first member of cyclic lipopeptides came into use in the treatment of resistant gram-positive infections. It is shown to be a good option in the treatment of serious infections caused by gram-positive bacteria. Eosinophilic pneumonia may occur rarely during the use of daptomycin. In this paper we described 5 cases of daptomycin-associated eosinophilic pneumonia. Sudden onset of respiratory failure with tachypnea, tachycardia was observed, peripheral eosinophilia was detected in one patient. The symptoms usually resolved with supportive treatment and after discontinuation of the drug, but steroid treatment and mechanical ventilation was required in some patients. Eosinophilic pneumonia in the sudden onset of respiratory failure should be kept in mind during daptomycin treatment.Daptomisin, dirençli gram pozitif enfeksiyonların tedavisinde kullanıma giren siklik lipopeptidlerin ilk üyesidir. Gram pozitif bakteriler ile oluşan ciddi enfeksiyonların tedavisinde iyi bir seçenek olabileceği çeşitli çalışmalarda gösterilmiştir. Eozinofilik pnömoni daptomisin kullanımı sırasında nadiren gelişebilir. Bu yazıda daptomisin ilişkili eozinofilik pnömoni düşünülen 5 olgu sunulmuştur. Hastalarda ani gelişen solunum yetmezliği, takipne, taşikardi görülmüş, bir olguda periferik eozinofili saptanmıştır. Destek tedavisi ve ilacın kesilmesiyle genellikle semptomlar kontrol altına alınmış, ancak bazı hastalarda steroid ve mekanik ventilasyon ihtiyacı olmuştur. Daptomisin kullanımı esnasında ani gelişen solunum yetmezliğinde eozinofilik pnömoni akılda tutulmalıdır.

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“…Indeed, in the U.S., influenza and pneumonia are the fifth leading cause of death in patients over the age of 65 (37). Although it remains unclear why the elderly are more susceptible to pneumonia and other lung diseases, it is interesting to note that similar increases in susceptibility may follow exposure to ozone (21,38,59) or high levels of therapeutic oxygen (4), strongly suggesting that oxidative processes may be involved.Reactive oxygen and nitrogen species (RONS) play a very prominent role in lung biology and pathology. They come from a variety of exogenous sources, and endogenous RONS may be generated by mechanisms that macrophages and other immune cells in the lung use to initiate and regulate inflammation and disable invading pathogens.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Age-related changes in the expression and oxidation of bronchoalveolar lavage proteins in the rat

Umstead¹,

Freeman²,

Chinchilli³

et al. 2009

American Journal of Physiology-Lung Cellular and Molecular Phys

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Umstead TM, Freeman WM, Chinchilli VM, Phelps DS. Age-related changes in the expression and oxidation of bronchoalveolar lavage proteins in the rat. Am J Physiol Lung Cell Mol Physiol 296: L14-L29, 2009. First published October 17, 2008 doi:10.1152/ajplung.90366.2008The incidence and severity of many lung diseases change with age. Some diseases, such as pneumonia, occur with increased frequency in children and the elderly. Proteins obtained by bronchoalveolar lavage (BAL) serve as the first line of defense against inhaled toxins and pathogens. Age-related changes in BAL protein expression and oxidative modification were examined in juvenile (1 mo), young adult (2 mo), and aged (18 mo) F344 rats using two-dimensional difference gel electrophoresis (2D-DIGE), matrix-assisted laser desorption ionization-time of flight/time of flight (MALDI-ToF/ToF) tandem mass spectrometry, and carbonyl immunoblotting. Using 2D-DIGE, we detected 563 protein spots, and MALDI-ToF/ToF identified 204 spots comprising 31 proteins; 21 changed significantly (17 increases) between juvenile and young adult or aged rats, but for 12 of these proteins, levels had a biphasic pattern, and levels in aged rats were less than in young adults. Relative carbonylation was determined by comparison of immunostaining with total protein staining on each oxidized protein blot. We found that aged rats had significantly increased oxidation in 13 proteins compared with juvenile rats. Many of the proteins altered in expression or oxidation level had functions in host defense, redox regulation, and protein metabolism. We speculate that low levels of expression of host defense proteins in juvenile rats and decreases in levels of these proteins between young adult and aged rats may predispose these groups to pneumonia. In addition, we have shown age-related increases in protein oxidation that may compromise host defense function in aged rats.aging; proteomics; host defense; carbonylation; proteolysis AGE IS A MAJOR FACTOR in the incidence of various lung diseases, particularly in the young and the old. Lung diseases, including chronic conditions such as emphysema and pulmonary fibrosis and acute lung diseases such as pneumonia, currently affect more than 35 million people in the U.S. Many of these diseases occur with increased frequency and severity in the elderly. However, pneumonia is also a serious problem in young children, both in developing countries, where it can be the leading cause of childhood mortality (48), and in developed countries, where morbidity is significant but mortality is low (16,43).Age also plays a role in how both humans and laboratory animals respond to pollution and various other insults. Aged organisms have an increased inflammatory response to oxidants, pollutants, and other insults (14,15,27,36,40) and are far more likely to become infected. Indeed, in the U.S., influenza and pneumonia are the fifth leading cause of death in patients over the age of 65 (37). Although it remains unclear why the elderly are more susceptible to pneumon...

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Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection

Cited by 68 publications

References 51 publications

Hormonal Influences on Lung Function and Response to Environmental Agents: Lessons from Animal Models of Respiratory Disease

Hormonal Influences on Lung Function and Response to Environmental Agents: Lessons from Animal Models of Respiratory Disease

Daptomisin alan hastalarda gelişen ani solunum yetmezliği ve eozinofilik pnömoni: beş olgunun sunumu

Age-related changes in the expression and oxidation of bronchoalveolar lavage proteins in the rat

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