Sex differences in the expression of lupus-associated miRNAs in splenocytes from lupus-prone NZB/WF1 mice

Dai, Rujuan; McReynolds, Savannah; LeRoith, Tanya; Heid, Bettina; Liang, Zhengmin; Ahmed, S. Ansar

doi:10.1186/2042-6410-4-19

Cited by 56 publications

(60 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…similarly, before the onset of sle, the two genders do not differ in their expression of mirs (mir-182-96-183, mir-31 and mir-148a, mir-155) except mir-127 and mir-379. after sle onset, however, the levels of mir-182-96-183, mir-31, mir-127, mir-379 and mir-148a are elevated in 30 weeks old females compared to age-matched males without sle features 84 . Furthermore, estrogen-treated orchiectomized 32 weeks old mice express similar levels of these mirs as their female counterparts 84 .…”

Section: Mirs and Hormonal Influences In Slementioning

confidence: 79%

“…after sle onset, however, the levels of mir-182-96-183, mir-31, mir-127, mir-379 and mir-148a are elevated in 30 weeks old females compared to age-matched males without sle features 84 . Furthermore, estrogen-treated orchiectomized 32 weeks old mice express similar levels of these mirs as their female counterparts 84 . all these data explain the modulation of mirs by estrogen and support selected mirs as mediators of the alteration of immune reactions to autoimmunity by sex hormones.…”

Section: Mirs and Hormonal Influences In Slementioning

confidence: 79%

“…Female dicer-deficient mice (cd19-cre ki/+ dicer fl/fl ) develop during ageing autoimmune features such as production of autoantibodies against cardiolipin, anti-dsdNa antibody production, and autoimmune kidney involvement, because lymphocyte infiltration and overall damage to the glomerulus architecture appears in 50% of them 83 . on the other hand, as demonstrated in orchiectomized lupus-prone NZB/W F1 mice, long-term estrogen treatment causes development of sle and elevation of mir182-96-183 cluster, mir-379 and mir-148a levels, but no correlation between anti-dsdNa and these mirs was found after 26 weeks of estrogen treatment 84 . Female NZB/W F1 lupus mice typically express the disease earlier than males.…”

Section: Mirs and Hormonal Influences In Slementioning

confidence: 86%

See 2 more Smart Citations

MicroRNAs in the key events of systemic lupus erythematosus pathogenesis

Hušáková¹

2016

BIOMED PAP

View full text Add to dashboard Cite

Background. Small non-coding RNA molecules (miRs) are involved in immune cell maturation and function and might influence immunopathological processes of systemic lupus erythematosus (SLE) pathogenesis. Methods and Results. This paper presents the results of a literature search for publications dealing with the relationship between miRs and pathological factors related to SLE such as genetic background, immune dysregulation and gender-associated differences participating in SLE development. In SLE, distinct miRs are differentially expressed in SLE cells of innate and adaptive immunity. The miR-146a and miR-155 genes, among others, interfere with intracellular signalling pathways downstream of toll-like receptors 7 and 9 (TLR-7, TLR-9) and influences interferon (IFN)-type I synthesis in plasmacytoid dendritic cells. In T and B cells, miR-126, miR-21, miR-146a, miR-155, miR-1246 and others might influence gene expression by epigenetic modifications, support abnormal cytosine release, differentiation of cell subsets, B cell hyperactivity and autoantibody production. Besides, estrogen might up-and downregulate immunologically active miRs, which are potential mediators of hormonal influences in SLE development. Moreover, SLE genetic basis included some polymorphisms of the miR-146a gene, which varies across populations. Conclusion. Distinct miRs are differentially expressed in both SLE mice models and human patients and promote autoimmune features of immune processes. MiRs are important molecules modulating susceptibility to SLE as well as its onset, clinical diversity and progression.

show abstract

Section: Mirs and Hormonal Influences In Slementioning

confidence: 79%

Section: Mirs and Hormonal Influences In Slementioning

confidence: 79%

Section: Mirs and Hormonal Influences In Slementioning

confidence: 86%

See 1 more Smart Citation

MicroRNAs in the key events of systemic lupus erythematosus pathogenesis

Hušáková¹

2016

BIOMED PAP

View full text Add to dashboard Cite

show abstract

“…In addition, activated ERα attenuates the processing of specific primary miRNAs into pre-miRNAs through estrogen-dependent association with the Drosha complex, resulting in an increased stabilization of the miRNA-targeting transcript. This suggests that estrogen can post-transcriptionally control gene expression through regulation of the miRNAs, which target the 3′UTRs of these genes (120, 121). …”

Section: Environmental and Hormonal Regulation Of Mirnas In Lupusmentioning

confidence: 99%

MicroRNAs in lupus

2014

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of an array of pathogenic autoantibodies, including high-affinity anti-dsDNA IgG antibodies, which plays an important role in disease development and progression. Lupus preferentially affects women during their reproductive years. The pathogenesis of lupus is contributed by both genetic factors and epigenetic modifications that arise from exposure to the environment. Epigenetic marks, including DNA methylation, histone post-translational modifications and microRNAs (miRNAs), interact with genetic programs to regulate immune responses. Epigenetic modifications influence gene expression and modulate B cell functions, such as class switch DNA recombination (CSR), somatic hypermutation (SHM) and plasma cell differentiation, thereby informing the antibody response. Epigenetic dysregulation can result in aberrant antibody responses to exogenous antigens or self-antigens, such as chromatin, histones and dsDNA in lupus. miRNAs play key roles in the post-transcriptional regulation of most gene-regulatory pathways and regulate both the innate and the adaptive immune responses. In mice, dysregulation of miRNAs leads to aberrant immune responses and development of systemic autoimmunity. Altered miRNA expression has been reported in human autoimmune diseases, including lupus. The dysregulation of miRNAs in lupus could be the result of multiple environmental factors, such as sex hormones and viral or bacterial infection. Modulation of miRNA is a potential therapeutic strategy for lupus.

show abstract

“…Numerous dysregulated miRNAs have been identified in both human and murine lupus, thereby implicating their role in lupus pathogenesis 13,17,19. To determine the contribution of sexually dimorphic miRNA expression to the sex bias of autoimmune disease, we recently investigated the sex differences in the expression of lupus-associated miRNAs, including the miR-182-96-183 cluster, miR-155, miR-31, miR-148a, miR-127, and miR-379, in splenocytes of male and female NZB/W F1 mice 16,22. We found that the sex differences in the expression of aforementioned lupus-associated miRNAs were markedly evident after the onset of lupus, especially at 30 weeks of age when female NZB/W F1 mice manifested moderate to severe lupus.…”

Section: Sexually Dimorphic Mirna Expression In Immune Cells In the Cmentioning

confidence: 99%

Sexual dimorphism of miRNA expression: a new perspective in understanding the sex bias of autoimmune diseases

Dai¹,

Ahmed²

2014

TCRM

Self Cite

View full text Add to dashboard Cite

Autoimmune diseases encompass a diverse group of diseases which emanate from a dysregulated immune system that launches a damaging attack on its own tissues. Autoimmune attacks on self tissues can occur in any organ or body system. A notable feature of autoimmune disease is that a majority of these disorders occur predominantly in females. The precise basis of sex bias in autoimmune diseases is complex and potentially involves sex chromosomes, sex hormones, and sex-specific gene regulation in response to internal and external stimuli. Epigenetic regulation of genes, especially by microRNAs (miRNAs), is now attracting significant attention. miRNAs are small, non-protein-coding RNAs that are predicted to regulate a majority of human genes, including those involved in immune regulation. Therefore, it is not surprising that dysregulated miRNAs are evident in many diseases, including autoimmune diseases. Because there are marked sex differences in the incidence of autoimmune diseases, this review focuses on the role of sex factors on miRNA expression in the context of autoimmune diseases, an aspect not addressed thus far. Here, we initially review miRNA biogenesis and miRNA regulation of immunity and autoimmunity. We then summarize the recent findings of sexual dimorphism of miRNA expression in diverse tissues, which imply a critical role of miRNA in sex differentiation and in sex-specific regulation of tissue development and/or function. We also discuss the important contribution of the X chromosome and sex hormones to the sexual dimorphism of miRNA expression. Understanding sexually dimorphic miRNA expression in sex-biased autoimmune diseases not only offers us new insight into the mechanism of sex bias of the disease but will also aid us in developing new sex-based therapeutic strategies for the efficient treatment of these diseases with a sex bias.

show abstract

Sex differences in the expression of lupus-associated miRNAs in splenocytes from lupus-prone NZB/WF1 mice

Cited by 56 publications

References 49 publications

MicroRNAs in the key events of systemic lupus erythematosus pathogenesis

MicroRNAs in the key events of systemic lupus erythematosus pathogenesis

MicroRNAs in lupus

Sexual dimorphism of miRNA expression: a new perspective in understanding the sex bias of autoimmune diseases

Contact Info

Product

Resources

About