Sex differences in the expression of estrogen receptor alpha within noradrenergic neurons in the sheep brain stem

Rose, Jessica; Hamlin, Adam; Scott, Christopher J.

doi:10.1016/j.domaniend.2014.04.003

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…In animals, sex-based differences have been seen in AR and ER expression on dopaminergic and noradrenergic neurons (Milner et al, 2007 ; Kritzer and Creutz, 2008 ; Tao et al, 2012 ; Rose et al, 2014 ), in the forebrain (Shah et al, 2004 ; Milner et al, 2010 ; Zuloaga et al, 2014 ), hippocampus (Milner et al, 2010 ; Tsai et al, 2015 ), cortex (Milner et al, 2010 ), and hypothalamus (Lu et al, 1998 ; Zhang et al, 2002 ; Shah et al, 2004 ; Vida et al, 2008 ; Milner et al, 2010 ; Kelly et al, 2013 ; Brock et al, 2015 ; Jahan et al, 2015 ; Kyi-Tha-Thu et al, 2015 ).…”

Section: Sex Hormones and Receptors In The Cnsmentioning

confidence: 99%

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

Congdon

2018

Front. Neurosci.

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Alzheimer's disease (AD) is the most common form of dementia, with over 5. 4 million cases in the US alone (Alzheimer's Association, 2016). Clinically, AD is defined by the presence of plaques composed of Aβ and neurofibrillary pathology composed of the microtubule associated protein tau. Another key feature is the dysregulation of autophagy at key steps in the pathway. In AD, disrupted autophagy contributes to disease progression through the failure to clear pathological protein aggregates, insulin resistance, and its role in the synthesis of Aβ. Like many psychiatric and neurodegenerative diseases, the risk of developing AD, and disease course are dependent on the sex of the patient. One potential mechanism through which these differences occur, is the effects of sex hormones on autophagy. In women, the loss of hormones with menopause presents both a risk factor for developing AD, and an obvious example of where sex differences in AD can stem from. However, because AD pathology can begin decades before menopause, this does not provide the full answer. We propose that sex-based differences in autophagy regulation during the lifespan contribute to the increased risk of AD, and greater severity of pathology seen in women.

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Section: Sex Hormones and Receptors In The Cnsmentioning

confidence: 99%

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

Congdon

2018

Front. Neurosci.

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Animal Models of Adrenocortical Tumorigenesis

Galac

Wilson

2015

Endocrinology and Metabolism Clinics of North America

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Over the past decade, research on human adrenocortical neoplasia has been dominated by gene expression profiling of tumor specimens and by analysis of genetic disorders associated with a predisposition to these tumors. Although these studies have identified key genes and associated signaling pathways that are dysregulated in adrenocortical neoplasms, the molecular events accounting for the frequent occurrence of benign tumors and low rate of malignant transformation remain unknown. Moreover, the prognosis for patients with adrenocortical carcinoma remains poor, so new medical treatments are needed. Naturally occurring and genetically engineered animal models afford a means to investigate adrenocortical tumorigenesis and to develop novel therapeutics. This comparative review highlights adrenocortical tumor models useful for either mechanistic studies or preclinical testing. Three model species -mouse, ferret, and dog -are reviewed, and their relevance to adrenocortical tumors in humans is discussed.

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Sex differences in the expression of estrogen receptor alpha within noradrenergic neurons in the sheep brain stem

Cited by 2 publications

References 44 publications

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

Animal Models of Adrenocortical Tumorigenesis

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