Sex differences in the diathetic effects of shift work schedules on circulating cytokine levels and pathological outcomes of ischemic stroke during middle age

Earnest, David J.; Burns, Shaina; Pandey, Sivani; Mani, Kathiresh Kumar; Sohrabji, Farida

doi:10.1016/j.nbscr.2022.100079

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Both experimental and clinical studies provide evidence of the impact of circadian misalignment on stroke development (Fig. 1 ), including an increase in the brain lesion volume, demonstrated worse functional dysfunction, and higher mortality which is likely due to the imbalance in the expression of pro- and anti-inflammatory cytokine genes in the brain [ 20 – 22 ]. However, some authors suggest that single light-induced circadian disruption is not potent enough to cause increased cerebral vulnerability to ischemia, and other concomitant factors or diseases are required [ 23 ].…”

Section: Circadian Pattern Of Stroke Occurrencementioning

confidence: 99%

Circadian Factors in Stroke: A Clinician’s Perspective

Korostovtseva

Коломейчук

2023

Cardiol Ther

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Stroke remains one of the leading causes of mortality and long-term and permanent disability worldwide despite technological innovations and developments in pharmacotherapy. In the last few decades, the growing data have evidenced the role of the circadian system in brain vulnerability to damage, the development and evolution of stroke, and short-term and long-term recovery. On the other hand, the stroke itself can affect the circadian system via direct injury of specific brain structures involved in circadian regulation (i.e., hypothalamus, retinohypothalamic tracts, etc.) and impairment of endogenous regulatory mechanisms, metabolic derangement, and a neurogenic inflammatory response in acute stroke. Moreover, the disruption of circadian rhythms can occur or exacerbate as a result of exogenous factors related to hospitalization itself, the conditions in the intensive care unit and the ward (light, noise, etc.), medication (sedatives and hypnotics), and loss of external factors entraining the circadian rhythms. In the acute phase of stroke, patients demonstrate abnormal circadian variations in circadian biomarkers (melatonin, cortisol), core body temperature, and rest–activity patterns. The approaches aimed at the restoration of disrupted circadian patterns include pharmacological (melatonin supplementation) and non-medication (bright light therapy, shifting feeding schedules, etc.) interventions; however, their effects on short- and long-term recovery after stroke are not well understood.

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Section: Circadian Pattern Of Stroke Occurrencementioning

confidence: 99%

Circadian Factors in Stroke: A Clinician’s Perspective

Korostovtseva

Коломейчук

2023

Cardiol Ther

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“…It is also suggested that potential disease-related brain structural changes along with chronic circadian rhythm disruption may occur before the occurrence of many brain disorders [ 5 ]. In the animal stroke model, studies have demonstrated that circadian rhythm dysregulation caused by chronic shifts in the light-dark cycle could amplify the extent of stroke-induced brain injury and functional impairment [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Night shift work was associated with functional outcomes in acute ischemic stroke patients treated with endovascular thrombectomy

Yu,

Ma,

Guo

et al. 2024

Heliyon

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Unhealthy lifestyle associated with increased risk of macro- and micro-vascular comorbidities in patients with long-duration type 2 diabetes: results from the Taiwan Diabetes Registry

Sheu

et al. 2023

Diabetol Metab Syndr

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Background Unhealthy lifestyle has been associated with obesity and type 2 diabetes. Whereas its association with vascular complications in patients with long-duration of type 2 diabetes is still uncertain. Methods A total of 1188 patients with long-duration of type 2 diabetes from the Taiwan Diabetes Registry (TDR) data were analyzed. We stratified the severity of unhealthy lifestyle via scoring three factors (sleep duration <7 or >9 h, sit duration ≥ 8h, and meal numbers ≥ with night snack) and analyzed their associations with the development of vascular complications using logistic regression analysis. Besides, we also included 3285 patients with newly diagnosed type 2 diabetes as the comparison. Results Increased numbers of factors that stand for unhealthy lifestyle were significantly associated with the development of cardiovascular disease, peripheral arterial occlusion disease (PAOD) and nephropathy in patients with long-duration of type 2 diabetes. After adjusting multiple covariables, having ≥ 2 factors of unhealthy lifestyle remained significant associations with cardiovascular disease and PAOD, with an odds ratio (OR) of 2.09 (95% confidence interval [CI] 1.18–3.69) and 2.68 (95% CI 1.21–5.90), respectively. Among individual factor for unhealthy lifestyle behaviors, we revealed that eating ≥ 4 meals per day with night snack increased the risk of cardiovascular disease and nephropathy after multivariable adjustment (OR of 2.60, 95% CI 1.28–5.30; OR of 2.54, 95% CI 1.52–4.26, respectively). Whereas sit duration for ≥ 8 h per day increased the risk of PAOD (OR of 4.32, 95% CI 2.38–7.84). Conclusion Unhealthy lifestyle is associated with increased prevalence of macro- and micro-vascular comorbidities in Taiwanese patients with long-duration type 2 diabetes.

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Sex differences in the diathetic effects of shift work schedules on circulating cytokine levels and pathological outcomes of ischemic stroke during middle age

Cited by 3 publications

References 36 publications

Circadian Factors in Stroke: A Clinician’s Perspective

Circadian Factors in Stroke: A Clinician’s Perspective

Night shift work was associated with functional outcomes in acute ischemic stroke patients treated with endovascular thrombectomy

Unhealthy lifestyle associated with increased risk of macro- and micro-vascular comorbidities in patients with long-duration type 2 diabetes: results from the Taiwan Diabetes Registry

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