Sex differences in the conditioned rewarding effects of cocaine

Russo, Scott J.; Jenab, Shirzad; Fabian, Sosimo J.; Festa, Eugene D.; Kemen, Lynne M.; Quiñones-Jenab, Vanya

doi:10.1016/s0006-8993(03)02346-1

Cited by 159 publications

(121 citation statements)

References 27 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Prior work confirms that males display place aversion or very modest preference for 10 mg/kg IP cocaine but strongly prefer higher IP doses (20 mg/kg; Nomikos and Spyraki 1988;Mayer and Parker 1993;Russo et al 2003b), whereas postpartum and virgin females prefer IP cocaine at lower doses (5-10 mg/kg; Russo et al 2003a, b;present study). This sharp gender contrast may be partially attributable to global endocrinological, physiological, and/or pharmacokinetic differences between males and females, previously proposed to underlie cycling females' heightened vulnerability to cocaine's motoric and motivational effects (Becker 1999;Kuhn et al 2001;Chin et al 2002;Hu and Becker 2003;Russo et al 2003a, b;Carroll et al 2004;.…”

Section: Discussionsupporting

confidence: 83%

“…While cocaine CPP is influenced by sex (Russo et al 2003b;Carroll et al 2004;Jackson et al 2006), estrus cycle stage (Roberts et al 1989;Hecht et al 1999), and exogenous administration of ovarian hormones (Russo et al 2003a(Russo et al , 2008, little research exists on cocaine CPP across the postpartum period, a complex phase characterized by subtle fluctuations in endogenous ovarian hormones and neuroactive peptides and influenced uniquely by biologically relevant stimuli (i.e., pups). The present study constitutes the first systematic examination of cocaine's incentive value across this unique period in the natural lifecycle of the female rat.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

View full text Add to dashboard Cite

Rationale-Objectives-Our prior conditioned place preference (CPP) work demonstrates that late (day16) postpartum female rats consistently prefer cocaine-over pup-associated chambers, whereas far fewer early postpartum (day8) females prefer the cocaine-associated chamber. The present study examines early and late postpartum females' preference for a cocaine-associated chamber when contrasted with a chamber associated with saline (rather than pups).Materials and methods-Postpartum females were tested for conditioned preference for chambers associated with cocaine (10 mg/kg subcutaneous (SC) or 0.5, 5, 10, or 20 mg/kg intraperitoneal (IP) injections) versus saline; preferences of virgin female and male rats for select cocaine stimuli (10mg/kg SC or IP) were also tested. Locomotion was recorded during CPP conditioning and testing.Results-Early and late postpartum females expressed strikingly similar preference for the cocaineassociated chamber across all administration routes and doses. IP cocaine produced an orderly, inverted U-shaped dose-preference curve, with preference peaking at the 5 mg/kg dose (83% of females). While many postpartum females preferred 10mg/kg cocaine administered either SC or IP, both virgin females and males expressed strong aversion to SC cocaine and, while virgin females strongly preferred IP cocaine, males remained relatively indifferent. Across 10mg/kg IP cocaineconditioning sessions, locomotor sensitization occurred exclusively in cocaine-but not salinepreferring postpartum females. Locomotor rate was lower in preferred versus nonpreferred chambers at CPP test.Conclusions-Early and late postpartum females may be equally and uniquely susceptible to sampling and/or abuse of modestly salient doses of cocaine (10mg/kg SC; 5mg/kg IP) compared to virgin females and/or males.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Results indicated, however, that the magnitude of Mn-induced toxicity in the nucleus accumbens, and other relevant brain regions, was apparently insufficient to impair performance on the CPP task. Additionally, CPP performance has been reported to vary according to sex, with female rats and mice showing more robust place preferences than males (Russo et al, 2003;Balda et al, 2006; but see Crawford et al, 1995;Campbell and Spear, 1999). For this reason we included both sexes in the CPP experiment but found that (a) Mn did not differentially affect place preference conditioning of male and female rats, and (b) preference testing and reinstatement performance did not differ according to sex (perhaps due to insufficient n).…”

Section: Discussionmentioning

confidence: 99%

“…Female rats and mice often show a more robust place preference than males (Russo et al, 2003;Balda et al, 2006), therefore the ability of Mn to differentially affect the CPP performance of male and female rats was assessed during a 20-day CPP procedure. The CPP experiment consisted of one preconditioning day, eight conditioning days, one preference test day, eight extinction days, one extinction test day, and one reinstatement test day.…”

Section: Place Preference Conditioningmentioning

confidence: 99%

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

McDougall¹,

Reichel²,

Farley³

et al. 2008

Neuroscience

View full text Add to dashboard Cite

In the present study, we examined whether exposing rats to a high-dose regimen of manganese chloride (Mn) during the postnatal period would depress presynaptic dopamine functioning and alter nonassociative and associative behaviors. To this end, rats were given oral supplements of Mn (750 μg/day) on postnatal days (PD) 1-21. On PD 90, dopamine transporter (DAT) immunoreactivity and [ 3 H]dopamine uptake were assayed in the striatum and nucleus accumbens, while in vivo microdialysis was used to measure dopamine efflux in the same brain regions. The effects of postnatal Mn exposure on nigrostriatal functioning were evaluated by assessing rotorod performance and amphetamine-induced stereotypy in adulthood. In terms of associative processes, both cocaineinduced conditioned place preference (CPP) and sucrose-reinforced operant responding were examined. Results showed that postnatal Mn exposure caused persistent declines in DAT protein expression and [ 3 H]dopamine uptake in the striatum and nucleus accumbens, as well as long-term reductions in striatal dopamine efflux. Rotorod performance did not differ according to exposure condition, however Mn-exposed rats did exhibit substantially more amphetamine-induced stereotypy than vehicle controls. Mn exposure did not alter performance on any aspect of the CPP task (preference, extinction, or reinstatement testing), nor did Mn affect progressive ratio responding (a measure of motivation). Interestingly, acquisition of a fixed ratio task was impaired in Mn-exposed rats, suggesting a deficit in procedural learning. In sum, these results indicate that postnatal Mn exposure causes persistent declines in various indices of presynaptic dopaminergic functioning. Mninduced alterations in striatal functioning may have long-term impact on associative and nonassociative behavior.

show abstract

“…Previous reports have shown that female rats acquire cocaine-induced conditioned place preference (CPP) after lower doses and fewer conditioning sessions compared to male rats, suggesting that females may be more sensitive to the rewarding action of cocaine (Russo et al, 2003). Likewise, adolescent (PND34) and adult (PND 66) female rats were more sensitive and acquire cocaine CPP at lower doses than male rats (Zakharova et al, 2009).…”

Section: Introductionmentioning

confidence: 97%

Nicotine pretreatment reduced cocaine-induced CPP and its reinstatement in a sex- and dose-related manner in adult C57BL/6J mice

Singh

Lutfy

2017

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Previous preclinical studies have shown that nicotine pretreatment during adolescence increases the reinforcing actions of cocaine. However, little is known about the effect of prior nicotine administration on cocaine-induced conditioned place preference (CPP) and its reinstatement in adult mice. Besides, little information is available regarding the role of sex in this cross-talk between nicotine and cocaine. Thus, we examined if nicotine administration during adulthood would differentially alter cocaine-induced CPP, its extinction and reinstatement in male versus female mice and if the dose of nicotine was important in this regard. To this end, mice were pretreated with saline or nicotine (0.25 or 1 mg/ kg; twice daily for seven days) and then tested for place preference before and after single and repeated conditioning with cocaine (15 mg/kg). Mice were then exposed to extinction training and tested for reinstatement of CPP. Our results showed that male and female mice pretreated with saline and conditioned with cocaine each exhibited a robust CPP after a single cocaine conditioning. However, this response was blunted in mice pretreated with the lower but not higher dose of nicotine. Female mice pretreated with the lower dose nicotine also failed to show CPP after repeated conditioning. Reinstatement of cocaine-induced CPP was also blunted in these mice compared to their respective controls. Together, these results suggest that nicotine administration during adulthood exerts differential effects on cocaine-induced CPP and its reinstatement in male and female mice and the dose of nicotine is important in this regard.

show abstract

Sex differences in the conditioned rewarding effects of cocaine

Cited by 159 publications

References 27 publications

Incentive salience of cocaine across the postpartum period of the female rat

Incentive salience of cocaine across the postpartum period of the female rat

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

Nicotine pretreatment reduced cocaine-induced CPP and its reinstatement in a sex- and dose-related manner in adult C57BL/6J mice

Contact Info

Product

Resources

About