Sex differences in the cardiometabolic health of cannabis users with a psychotic illness

Waterreus, Anna; Prinzio, Patsy Di; Martin‐Iverson, Mathew T.; Morgan, Vera

doi:10.1016/j.drugalcdep.2018.11.006

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…When considering all the study population, an interaction was observed between gender and cannabis use (p for interaction < 0.001, after adjustment for all covariates). Previous studies presented gender differences in frequency of cannabis use and cardiovascular response 10 . Some evidence from animal models may suggest that gonadal hormones are implicated in the cannabinoid modulation of metabolism balance and can influence cannabinoid receptor density in a gender-dependent manner 58 .…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown growing evidence in better cardiometabolic health associated with cannabis use 1 – 3 , whereas other studies suggested that cannabis use increases cardiovascular (CV) risks 4 – 7 . Nevertheless, these studies focused on limited populations leading to influence the impact of cannabis use on CV health 8 , 9 and few studies have examined gender differences in cannabis use 10 , 11 . The use of medical cannabis is growing rapidly 12 , but on a limited knowledge regarding safety and efficacy in varied indications 13 .…”

Section: Introductionmentioning

confidence: 99%

“…High values in blood pressure (BP) have been correlated with CV morbidity and mortality 14 . However, the association between BP and the use of cannabis remains inconsistent 10 , 15 . Nevertheless, a study has described that cannabis can lead to decrease BP due to vasodilatation along with tachycardia 16 .…”

Section: Introductionmentioning

confidence: 99%

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Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status

Vallée

2023

Sci Rep

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The associations between blood pressure and cannabis use remain inconsistent. The purpose of our study was to examine gender stratified associations of cannabis use and blood pressure [systolic, diastolic blood pressure (BP), pulse pressure (PP)] levels among the general UK Biobank population based study. Among 91,161 volunteers of the UK Biobank population, cannabis use status was assessed by questionnaire and range as heavy, moderate, low and never users. Associations between cannabis use and BP were estimated using multiple gender linear regressions. In adjusted covariates models, lifetime heavy cannabis use was associated with decrease in both SBP, DBP and PP in both genders, but with a higher effect among women (for SBP in men, b = − 1.09 (0.27), p < 0.001; in women, b = − 1.85 (0.36), p < 0.001; for DBP in men, b = − 0.50 (0.15), p < 0.001; in women, b = − 0.87 (0.17), p < 0.001; and for PP in men, b = − 0.60 (0.20), p < 0.001; in women, b = − 0.97 (0.27), p < 0.001. Among men, lower SBP and DBP levels were observed with participants without dyslipidemia and lower PP in participants with high income levels. Among women, lower SBP, DBP and PP were observed with current smokers, moderate/low alcohol levels and participants without dyslipidemia. Current cannabis use was associated with lower SBP levels in men (b = − 0.63 (0.25), p = 0.012) and in women (b = − 1.17 (0.31), p < 0.001). Same results were observed for DBP and PP. Negative association between BP in men was found but not in women. The small association in BP differences between heavy users and never users remains too small to adopt cannabis-blood pressure public policy in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status

Vallée

2023

Sci Rep

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“…For all the study population, an interaction was observed between sex and cannabis use ( P for interaction <0.001, after adjustment for all covariates). Previous studies presented sex differences in frequency of cannabis use and cardiovascular response [60]. Some evidence from animal models may suggest that gonadal hormones are implicated in the cannabinoid modulation of metabolism balance and can influence cannabinoid receptor density in a sex-dependent manner [61].…”

Section: Discussionmentioning

confidence: 99%

“…BMI was calculated as weight (in kg) divided by height 2 (metres) and categorized as high (BMI >30 kg/m 2 ), moderate (BMI between 25 and 30 kg/ m 2 ) and low (less than 25 kg/m 2 ). Age was categorized as (40-50 years), (50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60) and more than 60 years. Biologic parameters are detailed in the UK Biobank protocol [46].…”

Section: Laboratory and Clinical Parametersmentioning

confidence: 99%

Association between lifetime cannabis use and arterial stiffness in a middle-aged general population

Vallée¹

2023

Journal of Hypertension

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Background:No studies have investigated the association between arterial stiffness index (ASI) and cannabis use. The purpose of this study is to examine sex-stratified associations of cannabis use and ASI levels in a middle-aged general population.Methods:Cannabis use of 46 219 volunteers of the middle-aged UK Biobank population was assessed by questionnaire and investigates several aspects of cannabis use (lifetime, frequency and current status). Associations between cannabis use and ASI were estimated using sex multiple linear regressions. Covariates were tobacco status, diabetes dyslipidaemia, alcohol status, BMI categories, hypertension, mean blood pressure and heart rate.Results:Men presented higher ASI levels compared with women (respectively, 9.826 vs. 8.578 m/s, P < 0.001), a higher heavy lifetime cannabis users (4.0 vs. 1.9%, P < 0.001), higher current cannabis users (3.1 vs. 1.7%, P < 0.001), higher current smokers (8.4 vs. 5.8%, P < 0.001) and higher alcohol users (95.6 vs. 93.4%, P < 0.001). After adjustment for all covariates in sex models, heavy lifetime cannabis users were associated with higher ASI levels in men [b = 0.19, 95% confidence interval (0.02; 0.35)] but not in women [b = –0.02 (–0.23; 0.19)]. Current cannabis users were associated with higher ASI levels in men [b = 0.17 (0.01; 0.32)] but not in women [b = –0.01 (–0.20; 0.18)] and among cannabis users, every day frequency was associated with increased ASI levels in men [b = 0.29 (0.07; 0.51)] but not in women [b = 0.10 (–0.17; 0.37)].Conclusion:The observed association between cannabis use and ASI could participate in accurate and appropriate cardiovascular risk reduction strategies among cannabis users.

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Psychotropic Effects of Cannabis

Ross

2023

Plant-Based Therapeutics, Volume 1

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Sex differences in the cardiometabolic health of cannabis users with a psychotic illness

Cited by 6 publications

References 55 publications

Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status

Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status

Association between lifetime cannabis use and arterial stiffness in a middle-aged general population

Psychotropic Effects of Cannabis

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