Sex differences in survival after out-of-hospital cardiac arrest: a meta-analysis

Lei, Hao; Hu, Jiahui; Liu, Leiling; Xu, Di

doi:10.1186/s13054-020-03331-5

Cited by 53 publications

(71 citation statements)

References 47 publications

(26 reference statements)

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“…A recent meta-analysis involving patient from 15 studies showed that there was no significant difference in hospital admission between females and males. The authors therefore speculated that some of the pre-hospital baseline characteristics such as age, bystander CPR, and shockable rhythm had no obvious immediate impact did not have an impact on the difference in resuscitation rate between the genders [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, there was considerable heterogeneity in patient selection among the aforementioned studies, and the sample size of these who suggested that women had a higher survival was much larger than those who did not [ 8 , 9 , 18 – 21 ]. On the other hand, women victims were less likely to receive post resuscitation interventions, such as coronary angiography, percutaneous coronary intervention, and TTM [ 5 , 6 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, an increasing number of studies have focused on the effect of gender on outcome of cardiac arrest [ 5 , 6 ]. The epidemiological investigation results showed that female and male victims differed significantly in characteristics of baseline and CPR.…”

Section: Introductionmentioning

confidence: 99%

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Interaction between gender and post resuscitation interventions on neurological outcome in an asphyxial rat model of cardiac arrest

Wang

Chen

et al. 2021

BMC Cardiovasc Disord

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Purpose Previous clinical studies have suggested an effect of gender on outcome after out-of-hospital cardiac arrest, but the results are conflicting and there is no uniform agreement regarding gender differences in survival and prognosis. The present study was aimed to investigate the interaction between gender and post resuscitation interventions on neurological outcome in an asphyxial rat model of cardiac arrest. Methods Asphyxia was induced by blocking the endotracheal tube in 120 adult Sprague–Dawley rats (60 males and 60 females) at the same age. Cardiopulmonary resuscitation (CPR) was started after 5 min of untreated cardiac arrest. Animals were randomized into one of the three post resuscitation care intervention groups (n = 40, 20 males) immediately after resuscitation: (1) normothermic control (NC): ventilated with 2% N2/98% O2 for 1 h under normothermia; (2) targeted temperature management (TTM): ventilated with 2% N2/98% O2 for 1 h under hypothermia; (3) hydrogen inhalation (HI): ventilated with 2% H2/98% O2 for 1 h under normothermia. Physiological variables were recorded during the 5 h post resuscitation monitoring period. Neurological deficit score (NDS) and accumulative survival were used to assess 96 h outcomes. Mutual independence analysis and Mantel–Haenszel stratified analysis were used to explore the associations among gender, intervention and survival. Results The body weights of female rats were significantly lighter than males, but CPR characteristics did not differ between genders. Compared with male rats, females had significantly lower mean arterial pressure, longer onset time of the electroencephalogram (EEG) burst and time to normal EEG trace (TTNT) in the NC group; relatively longer TTNT in the TTM group; and substantially longer TTNT, lower NDSs, and higher survival in the HI group. Mutual independence analysis revealed that both gender and intervention were associated with neurological outcome. Mantel–Haenszel stratified analysis demonstrated that female rats had significantly higher survival rate than males when adjusted for the confounder intervention. Conclusion In this rat model cardiac arrest and CPR, gender did not affect resuscitation but associated with neurological outcome. The superiority of female rats in neurological recovery was affected by post resuscitation interventions and female rats were more likely to benefit from hydrogen therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Interaction between gender and post resuscitation interventions on neurological outcome in an asphyxial rat model of cardiac arrest

Wang

Chen

et al. 2021

BMC Cardiovasc Disord

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“…Males and females experience different manifestations of cardiac arrest. Lei et al (2020) carried out a study to determine gender differences in neurological outcomes and found that females are more likely to have favorable neurological outcomes than males. After an admission, the females received fewer interventions such as coronary artery angiography and percutaneous coronary intervention, which are important for cardiac arrest patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of Cardiopulmonary Resuscitation Duration on the Neurological Outcomes of Out-of-Hospital Cardiac Arrest

Albinali¹,

Alumran

AlRayes

2021

Preprint

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Background: Patients experiencing cardiac arrest outside medical facilities are at greater risk of death and might have negative neurological outcomes. Cardiopulmonary resuscitation duration affects neurological outcomes of such patients, which suggests that duration of CPR may be vital to patient outcomes.Objectives: The study aims to evaluate the impact of cardiopulmonary resuscitation duration on neurological outcome of patients who have suffered out-of-hospital cardiac arrest.Methods: Data were collected from emergency cases handled by a secondary hospital in industrial Jubail, Saudi Arabia, between 2015 and 2020. There were 257 out-of-hospital cardiac arrest cases, 236 of which resulted in death.Results: Bivariate analysis showed no significant association between cerebral performance category (CPC) outcomes and duration of CPR, gender and cause of death whereas there is statistically significant between CPC and age. (p = 0.001). However, a good CPC outcome was reported with a (mean) limited duration of 8.1 min of CPR; whereas, poor CPC outcomes were associated with prolonged periods of CPR, 13.2 min (mean). Similarly, youthfulness was associated with good CPC outcomes as revealed by the mean age of 5.8 years, whereas a mean rank of 14.9 years was aligned with a poor CPC outcome.Conclusion: Cardiopulmonary Resuscitation Duration out-of-hospital cardiac arrest does not significantly influence the patient neurological outcome in the current study hospital. Other variables may have a more significant effect.

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“…The German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI), the Robert Koch Institute (RKI) and the German Hospital Society (DKG) have activated together with the DIVI intensive care register. This website registers and queries for free ventilation places in all clinics in Germany to optimize the cooperation between the hospitals and to provide a real overview of the intensive bed situation in the nation [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Emergency surgical management of cervical spine fracture-dislocation with acute paraplegia in COVID-19 (Coronavirus disease 2019)-suspected patient: first experience from a German spine centre

et al. 2020

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Purpose We present an organized hospital plan for the management of Coronavirus disease (COVID-19) patients requiring emergency surgical interventions. To introduce a multidisciplinary approach for the management of COVID-19-infected patients and to report the first operated patient in the Corona unit. Methods A detailed presentation of the hospital plan for a separate Corona unit with its intensive care unit and operating rooms. Description of the management of the first spine surgery case treated in this unit. Results The Corona unit showed a practical approach for the management of an emergency cervical spine fracture-dislocation with acute paralysis. The patient is 92-year-old female. The mechanism of injury was a simple fall during the stay in the internal medicine department where the patient was treated in the referring hospital. The patient had no other injuries and was awake and oriented. The patient did not have the clinical symptom of COVID-19, and the test result of COVID-19 done in the referring hospital was not available on admission in our emergency room. Education of the medical staff and organization of the operating theatre facilitated the management of the patient without an increased risk of spreading the infection. Conclusions The current COVID-19 pandemic requires an extra-ordinary organization of the medical and surgical care of the patients. It is possible to manage an infected or a potentially infected patient surgically, but a multidisciplinary plan is necessary to protect other patients and the medical staff.

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Sex differences in survival after out-of-hospital cardiac arrest: a meta-analysis

Cited by 53 publications

References 47 publications

Interaction between gender and post resuscitation interventions on neurological outcome in an asphyxial rat model of cardiac arrest

Interaction between gender and post resuscitation interventions on neurological outcome in an asphyxial rat model of cardiac arrest

Impact of Cardiopulmonary Resuscitation Duration on the Neurological Outcomes of Out-of-Hospital Cardiac Arrest

Emergency surgical management of cervical spine fracture-dislocation with acute paraplegia in COVID-19 (Coronavirus disease 2019)-suspected patient: first experience from a German spine centre

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