Sex differences in stroke across the lifespan: The role of T lymphocytes

Bravo-Alegría, Javiera; McCullough, Louise D.

doi:10.1016/j.neuint.2017.01.009

Cited by 16 publications

(12 citation statements)

References 147 publications

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“…The sample was comprised of more men than women ( Table 1 ), which is an expected result associated with the characteristics of the primary disease represented by stroke [ 68 ]. The age of the evaluated patients was similar between men and women but women had a tendency to have a significantly higher body mass index (BMI) than men ( p < 0.10).…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

Stănescu

Bulboacă

Micu

et al. 2020

JCM

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Background: Due to the higher frequency of ischemic stroke in men compared to women, we aimed to determine if gender differences exist regarding periodontal status and several plasma biomarkers in patients with a recent large artery atherosclerosis ischemic stroke (IS). Material and methods: Patients with their first IS within less than six weeks who were able to undergo periodontal examinations were evaluated. Demographic data, periodontal status, oxidative stress parameters/plasma antioxidant capacity, and C-reactive protein in patients who suffered a recent large artery atherosclerosis ischemic stroke were reccorded. Results: 93 patients were included in the study. More men were smokers (12/57 vs. 3/36) and consumed alcohol (17/57 vs. 3/36), and more women had higher glycemic values (p = 0.023), total cholesterol (p < 0.001), LDL (low-density lipoprotein)-cholesterol (p = 0.010), and HDL (high-density lipoprotein)-cholesterol (p = 0.005) levels. Significantly more men than women had moderate plus severe periodontal disease (p = 0.018), significantly higher levels of nitric oxide (p = 0.034), and significantly lower levels of total antioxidant capacity (p = 0.028). Conclusions: In this pilot study, men seem to be more prone to oxidative stress and to develop more severe forms of periodontitis among patients with stroke, but the results need validation on a larger sample.

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Section: Discussionmentioning

confidence: 99%

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

Stănescu

Bulboacă

Micu

et al. 2020

JCM

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“…Through this study and previously published manuscripts, this lab has demonstrated that LIF treatment after stroke promotes neuroprotection and recovery through two distinct mechanisms: Akt-dependent upregulation of antioxidant enzymes [ 46 , 47 ] and modulation of the IL-12 p40/IFNγ/IP-10 signaling pathway. Future studies dictate that these studies need to be replicated in aged rodents of both sexes, since several groups have identified sex-specific and age-dependent differences in stroke pathophysiology, specifically concerning the post-stroke immune response [ 82 – 86 ].…”

Section: Discussionmentioning

confidence: 99%

Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion

Davis

Collier

Winford

et al. 2018

J Neuroinflammation

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BackgroundThe migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation of antioxidant enzymes, promotes an anti-inflammatory phenotype in several types of immune cells. The goal of this study was to determine whether LIF treatment modulates the peripheral immune response after stroke.MethodsYoung male (3 month) Sprague-Dawley rats underwent sham surgery or permanent middle cerebral artery occlusion (MCAO). Animals were administered LIF (125 μg/kg) or PBS at 6, 24, and 48 h prior to euthanization at 72 h. Bone marrow-derived macrophages were treated with LIF (20 ng/ml) or PBS after stimulation with interferon gamma + LPS. Western blot was used to measure protein levels of CD11b, IL-12, interferon inducible protein-10, CD3, and the LIF receptor in spleen and brain tissue. ELISA was used to measure IL-10, IL-12, and interferon gamma. Isolectin was used to label activated immune cells in brain tissue sections. Statistical analysis was performed using one-way ANOVA and Student’s t test. A Kruskal-Wallis test followed by Bonferroni-corrected Mann-Whitney tests was performed if data did not pass the D’Agostino-Pearson normality test.ResultsLIF-treated rats showed significantly lower levels of the LIF receptor and interferon gamma in the spleen and CD11b levels in the brain compared to their PBS-treated counterparts. Fluorescence from isolectin-binding immune cells was more prominent in the ipsilateral cortex and striatum after PBS treatment compared to LIF treatment. MCAO + LIF significantly decreased splenic levels of CD11b and CD3 compared to sham surgery. MCAO + PBS treatment significantly elevated splenic levels of interferon inducible protein-10 at 72 h after MCAO, while LIF treatment after MCAO returned interferon inducible protein 10 to sham levels. LIF administration with interferon gamma + LPS significantly reduced the IL-12/IL-10 production ratio compared to macrophages treated with interferon gamma + LPS alone.ConclusionsThese data demonstrate that LIF promotes anti-inflammatory signaling through alterations of the IL-12/interferon gamma/interferon inducible protein 10 pathway.

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“…Furthermore, depending on the surface molecules, αβ T cells can be divided into CD4 + T cells and CD8 + T cells; the former can be further divided into T helpers (Th) and regulatory T cells (Treg) 12 . Notably, all types of T cells are closely involved in triggering inflammatory events in stroke 13 . In the acute phase of ischaemic stroke, Th1 and Th17 were destructive 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐17 and ischaemic stroke

et al. 2020

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SummaryInterleukin‐17 (IL‐17) is a cytokine family that includes 6 members, IL‐17A through IL‐17F, most of them are reported to have pro‐inflammatory role. Through binding to their receptors (IL‐17Rs), IL‐17 activates the intracellular signalling pathways to play an important role in autoimmune diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS). Ischaemic stroke is a complex pathophysiological process mainly caused by regional cerebral ischaemia. Inflammatory factors contribute to the physiological process of stroke that leads to poor prognosis. IL‐17 plays a crucial role in promoting inflammatory response and inducing secondary injury in post‐stroke. Though immune cells and inflammatory factors have been reported to be involved in the damage of stroke, the functions of IL‐17 in this process need to be elucidated. This review focuses on the pathological modulation and the mechanism of IL‐17 family in ischaemic stroke and seeking to provide new insights for future therapies.

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Sex differences in stroke across the lifespan: The role of T lymphocytes

Cited by 16 publications

References 147 publications

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

Gender Differences in the Levels of Periodontal Destruction, Behavioral Risk Factors and Systemic Oxidative Stress in Ischemic Stroke Patients: A Cohort Pilot Study

Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion

Interleukin‐17 and ischaemic stroke

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