Sex differences in sleep and sleep loss-induced cognitive deficits: The influence of gonadal hormones

Hajali, Vahid; Andersen, Mônica Levy; Negah, Sajad Sahab; Sheibani, Vahid

doi:10.1016/j.yhbeh.2018.12.013

Cited by 74 publications

(35 citation statements)

References 197 publications

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“…Severe sleep disturbance were more likely to affect women in executive shifting. Sex difference existed in cognitive processes and females were more influenced by sleep disturbance on cognitive function, which has been reported by several previous studies [42,43]. Orexin may modulate executive shifting and sleep in female mice, which can explain the sex difference found in our study [44].…”

Section: Discussionsupporting

confidence: 85%

Severe sleep disturbance is associated with executive function impairment in patients with first-episode, treatment-naïve major depressive disorders

Cui

Liu

et al. 2021

BMC Psychiatry

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Background Sleep disturbance and executive function impairment are common in patients with major depressive disorder (MDD), though the relationship between the two remains unclear. We investigated this association in first-episode, treatment-naïve patients with MDD. Methods We analyzed data from 242 patients with MDD. We divided the patients into 2 groups based on sleep disturbance severity and compared the executive function odds ratios between the groups. Results A total of 121 pairs of patients were matched (age 39.4 ± 10.1, 70.2% female). After propensity score matching, the odds ratios for cognitive impairment in patients with MDD and severe sleep disturbance were 1.922 (1.068–3.459, P = 0.029, q = 0.044) in executive functioning; 2.023 (1.211–3.379, P = 0.007, q = 0.021) in executive shifting. Conclusions Sleep disturbance is associated with executive functioning impairment in first-episode, treatment-naïve patients with MDD. Severe sleep disturbance can be a marker and aid in recognizing executive function impairment in patients with first-episode treatment-naïve MDD. Severe sleep disturbance can be a potential modifiable factor to improve executive function in MDD, as well as an effective measurement to improve cognition for sleep symptom management that should be enforced at initial treatment of first-episode MDD. Further study is required to confirm our results. Trial registration ClinicalTrials.gov: NCT02023567; registration date: December 2013.

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Section: Discussionsupporting

confidence: 85%

Severe sleep disturbance is associated with executive function impairment in patients with first-episode, treatment-naïve major depressive disorders

Cui

Liu

et al. 2021

BMC Psychiatry

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“…If severe, it may result in probable mental changes [e.g., inattention, hallucination, seclusiveness, irritability, and even aggressiveness; ( 47 )]. The degree of cognitive impairment caused by sleep disorder may range from subtle derangements in attention, reason, clarity of thought, and capacity for decision making, to confusion and delirium ( 48 ). Mehrnoush et al ( 49 ) found that sleep disturbance was common among patients undergoing coronary artery bypass graft surgery (CABG), especially during the first week of the postoperative period, which was partly due to disturbed melatonin secretion in the perioperative period.…”

Section: Functional Changes After Postoperative Sleep Disturbancesmentioning

confidence: 99%

Sleep Disturbances After General Anesthesia: Current Perspectives

2020

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The purpose of this article is to review (1) sleep mechanism under general anesthesia, harmful effects of postoperative sleep disturbances; (2) risk factors associated with postoperative sleep disturbances; (3) measures to prevent and improve postoperative sleep disturbances. General anesthesia changes the postoperative sleep structure especially in elderly patients after major surgery and results in a high incidence rate of sleep disturbances. Sleep disturbances produce harmful effects on postoperative patients and lead to a higher risk of delirium, more cardiovascular events, and poorer recovery. Some researchers do propose non-pharmacological treatments such as attention to environmental and psychological factors, application of electroacupuncture (EA) technology and pharmacological treatments are helpful, but larger high-quality clinical trials with longer following-up are needed to further investigate the efficacy and safety.

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“…The existence of sex differences at all levels of the central nervous system (CNS), including genetic, systemic, and behavioral level, are generally accepted [11], [12]. There are significant differences in sleep patterns and quality between females and males [13]. Some sleep-related disorders, and some neuropsychiatric disorders linked to sleep also show sex differences regarding clinical phenotype and prevalence.…”

Section: Introductionmentioning

confidence: 99%

Overall Population Generalities, Sex Differences, and Individual Differences in Sleep Electroencephalography Functional Connectivity

et al. 2019

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Sleep is indispensable for humans to maintain normal life activities. Sex and individual differences in sleep patterns and quality of sleep cannot be ignored. Nevertheless, the overall population generalities and sex-or individual-differences in cerebral cortical functional connectivity (FC) during sleep have not been well described. Here, we evaluated the characteristic patterns of FC based on whole-night sleep electroencephalography (EEG) recordings. An improved weighted phase lag index (WPLI) algorithm was applied to obtain the FC in delta (0.5-4Hz), theta (4-8Hz), alpha (8-12Hz) and beta band (12-32Hz). FC strength, short-term stability and inter-regional imbalance of FC were studied. We found that the variations in FC-related parameters among sleep stages had overall population commonalities, and these parameters also showed stage-and frequency band-dependent sex differences. With the deepening of norapid eye movement (NREM), increased delta and beta FC strength were observed. Rapid eye movement (REM) showed weaker FC strength, higher FC stability, and higher anterior-posterior FC anisotropy than NREM in beta band. Meanwhile, females exhibited higher sleep EEG synchronization and higher delta FC stability in deep NREM sleep than males. Moreover, the dominant hemisphere in terms of FC did not show group generality or stage-and frequency-dependence. Our results add to the understanding of sleep staging function and may provide clues to sex differences in sleep patterns and quality as well as the prevalence and clinical manifestations of sleep-related illness. Short-term stability offers a new perspective in analyzing FC, which cannot be ignored.INDEX TERMS Overall population generalities, sex differences, sleep stages, sleep EEG, functional connectivity.

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Sex differences in sleep and sleep loss-induced cognitive deficits: The influence of gonadal hormones

Cited by 74 publications

References 197 publications

Severe sleep disturbance is associated with executive function impairment in patients with first-episode, treatment-naïve major depressive disorders

Severe sleep disturbance is associated with executive function impairment in patients with first-episode, treatment-naïve major depressive disorders

Sleep Disturbances After General Anesthesia: Current Perspectives

Overall Population Generalities, Sex Differences, and Individual Differences in Sleep Electroencephalography Functional Connectivity

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