Sex Differences in Serotonin 1 Receptor Binding in Rat Brain

Fischette, Christine T.; Biegon, Anat; McEwen, Bruce S.

doi:10.1126/science.6623080

Cited by 150 publications

(36 citation statements)

References 35 publications

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“…Sex differences in 5-HT receptors have also been demonstrated. In the medial and lateral P O A , 5-HTi binding has been reported to be greater in males than females [25]. The 5-H T|a ago nist, 8 -O H -D P A T , has been shown to inhibit female sex behavior and enhance male sexual behavior [26], Sex dif ferences have also been found following 5,7-DHT-induced denervation.…”

Section: Discussionmentioning

confidence: 60%

Effect of 5,7-Dihydroxytryptamine, Ovariectomy and Gonadal Steroids on Serotonin Receptor Binding in Rat Brain

et al. 1994

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Quantitative autoradiography was used to assess alterations in serotonin (5-HT) receptor binding in the hypothalamus and hippocampus following denervation with 5, 7-dihydroxytryptamine (5, 7-DHT), ovariectomy (OVX) and gonadal steroid manipulation. Seven days after 5, 7-DHT injection, 5-HT_1a receptor density was significantly increased in the ventromedial hypothalamic nucleus (VMN) of intact but not OVX femaled rats. Under these conditions 5-HT_1b receptor density was unchanged in any brain region examined and 5-HT transporter binding was decreased in all 5, 7-DHT injected animals. In addition, there was a significant interaction between OVX and 5, 7-DHT for both the 5-HT_1a receptor and the 5-HT transporter in the VMN, such that OVX inhibited the 5, 7-DHT-induced increase in 5-HT_1a receptors and attenuated the 5, 7-DHT-induced decrease in 5-HT transporter binding. In a separate experiment the effect of gonadal steroid manipulation on 5-HT receptor binding was assessed. In female OVX rats, 5-HT_1a receptor density was unchanged by estrogen or estrogen and progesterone administration. In male rats, castration significantly decreased 5-HT_1a receptor density in the medial preoptic area. Estrogen and progesterone administration to female OVX rats increased the density of 5-HT_1b receptors in the VMN, as compared to estrogen alone. The relationship of these results to the role of 5-HT in mediating lordosis behavior is discussed.

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Section: Discussionmentioning

confidence: 60%

Effect of 5,7-Dihydroxytryptamine, Ovariectomy and Gonadal Steroids on Serotonin Receptor Binding in Rat Brain

et al. 1994

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“…Tryptophan administration concurrently with testos terone during neonatal life potentiates testosterone effects on defeminizing of female sexual behavior in rats [18]. Moreover, brain sex differences in the serotoninergic sys tem during development and adult life have been reported [4,9,15,16,21,34], The mechanisms whereby 5-HT endings exert inhibition on behavior and may contribute to neonatally programmed differences in behavioral expression are largely unknown. The possibility that loss of 5-HT might enhance estrogenic priming effects has not been supported, since the occupa tion of E nuclear receptors after estrogen priming of lesioned rats was not different from sham rats, nor was the level of estrogen-inducible progestin receptors [25].…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic Serotonin Lesions Unmask Hormone Responsiveness of Lordosis Behavior in Adult Male Rats

Moreines

Kelton²,

Luine³

et al. 1988

Neuroendocrinology

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Hypothalamic lesions of serotoninergic afferents following bilateral stereotoxic injections of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the region of the ventromedial hypothalamus enhanced the effects of hormonally induced lordosis responding in both male and female rats. However, similarities and differences in the enhanced responsiveness to ovarian hormones were observed between the sexes. Compared with sham-lesioned controls, lesioned males displayed elevated lordosis responding to estradiol (E) priming alone, as well as to priming with E followed by progesterone (P). On the other hand, lesioned females displayed elevated lordosis in response to E priming alone, but were not different from controls in a synergistic facilitation of lordosis by P after E priming. With respect to receptivity, neither lesioned nor control males displayed ear-wiggling and hop-darting in response to E + P, whereas both lesioned and control females were proceptive following this treatment. Therefore, hypothalamic lesions following 5,7-DHT increase lordosis, but fail to unmask in males the responsiveness to E + P priming mediating proceptive behaviours by females. Further, the levels of lordosis responding displayed by lesioned males are lower than those of either lesioned or control females after E + P priming, as well as those of lesioned females after E priming alone, thus indicating that other inhibitory mechanisms continue to operate in the lesioned males.

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“…The possibility of gender differences in the 5-HTTLPR personality association is raised by evidence of differential modulation of serotonergic neurotransmission in male and female animals [Fischette et al, 1983[Fischette et al, , 1984Zhang et al, 1997] and also in women and men [McBride et al, 1990;Nishizawa et al, 1997]. Furthermore, recent findings that estradiol markedly affects expression of the brain 5-HTT in female rats [McQueen et al, 1997], and results from our group that transgenic mice lacking the 5-HTT show gender-related differences in anxiety-like behaviors [Wichems et al, 1998], also suggest that gender might influence this association.…”

Section: Introductionmentioning

confidence: 99%

Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample

et al. 2000

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The serotonin transporter (5-HTT) regulates serotonergic neurotransmission and is thought to influence emotion. A 5-HTT-linked polymorphic region (5-HTTLPR) has two common variants, short (s) and long (l). We previously found population and within-family associations between the lower-expressing s allele and neuroticism, a trait related to anxiety, hostility, and depression, on a standard measure (the NEO Personality Inventory, Revised [NEO-PI-R]) in a primarily male population (n=505), and that the s allele was dominant. We investigated this association in a new sample (n=397, 84% female, primarily sib-pairs). The results robustly replicated the 5-HTTLPR neuroticism association, and the dominance of the s allele. Combined data from the two studies (n=902) showed a highly significant association between the s allele and higher NEO Neuroticism both across individuals and within families. Association between genotype and a related measure, Anxiety on the 16PF inventory, was replicated in the new population and within families in the combined sample. Association to another trait, estimated TPQ Harm Avoidance, was not replicated in the new sample but found only within the combined sibship group. Another association found in our original study, between the s allele and lower scores on NEO-PI-R Agreeableness, was also replicated and was more robust in the current and the combined samples. Associations between the functional 5-HTTLPR polymorphism were similar in women and men. These results help to define specific personality features reproducibly associated with 5-HTTLPR genotype. Such associations were strongest for traits defined by the NEO, enhancing the attractiveness of the five-factor personality model in genetic research on complex behavioral dimensions. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:202-216, 2000. Published 2000 Wiley-Liss, Inc.

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Sex Differences in Serotonin 1 Receptor Binding in Rat Brain

Cited by 150 publications

References 35 publications

Effect of 5,7-Dihydroxytryptamine, Ovariectomy and Gonadal Steroids on Serotonin Receptor Binding in Rat Brain

Effect of 5,7-Dihydroxytryptamine, Ovariectomy and Gonadal Steroids on Serotonin Receptor Binding in Rat Brain

Hypothalamic Serotonin Lesions Unmask Hormone Responsiveness of Lordosis Behavior in Adult Male Rats

Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample

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