Sex differences in reactivity of conscious and anesthetized rats to surgical stress

In healthy females the chronotropic effects of stress are more pronounced, while the hypertensive effects are weakened compared to males. Hemodynamic parameters in females returned to normal more rapidly than in males. Renovascular hypertension in males is more pronounced than in females and is associated with increased cardiovascular stress reactivity (in females it is associated with decreased cardiovascular stress reactivity), which increase the risk of cardiovascular complications in males.

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“…Here and in Fig. 3: females (1) and males (2). p<0.05: *compared to the basal level; + compared to males.…”

Section: Resultsmentioning

confidence: 88%

“…To this end, a silver clamp was applied to the left renal artery under nembutal anesthesia (35-40 mg/kg). The control group included intact, but not shamoperated animals, since blood corticosterone level returns to normal 1 day after laparotomy [2]. Persistent hypertension in rats developed 7 weeks after clamping.…”

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confidence: 99%

Sex-related differences in cardiovascular stress reactivity in healthy and hypertensive rats

Anishchenko

Glushkovskaya-Semyachkina

Berdnikova

et al. 2007

Bull Exp Biol Med

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“…Cholinergic effects were blocked and stimulated with atropine sulfate (0.2 mg/100 g) and acetylcholine chloride (ACC; 0.3 µg/100 g; Pharma), respectively, infused through a venous catheter. Intact (but not sham-operated) rats served as the control, because according to our data, blood corticosterone level normalized in rats as early as 24 h after surgical stress [1].…”

Section: Methodsmentioning

confidence: 98%

Sex-specific peculiarities of cholinergic regulation of the cardiovascular system in normal and hypertensive rats

Semyachkina-Glushkovskaya

Anishchenko

Berdnikova

et al. 2008

Bull Exp Biol Med

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“…Normotensive females and males were exposed to the same stress. Our previous studies showed that blood corticosterone level returns to normal 1 day after surgery [1], therefore we used healthy, but not sham-operated rats as controls.…”

Section: Methodsmentioning

confidence: 99%

Sex-related differences in nitric oxide content in healthy and hypertensive rats at rest and under stress conditions

Glushkovskaya-Semyachkina

Anishchenko

Sindyakova

et al. 2006

Bull Exp Biol Med

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Immobilization was followed by an increase in blood NO concentration in male and female rats. After renovascular hypertension modeling blood pressure was higher and the decrease in nitric oxide concentration was more pronounced in males than in females. The levels of nitric oxide in healthy and hypertensive females at rest and during stress were higher than in males. These specific features probably contribute to higher resistance of the cardiovascular system in females to pathological changes.

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Sex differences in reactivity of conscious and anesthetized rats to surgical stress

Cited by 9 publications

References 2 publications

Sex-related differences in cardiovascular stress reactivity in healthy and hypertensive rats

Sex-related differences in cardiovascular stress reactivity in healthy and hypertensive rats

Sex-specific peculiarities of cholinergic regulation of the cardiovascular system in normal and hypertensive rats

Sex-related differences in nitric oxide content in healthy and hypertensive rats at rest and under stress conditions

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