Sex differences in oxycodone-taking behaviors are linked to disruptions in reward-guided, decision-making functions
Kaitlyn LaRocco,
Peroushini Villiamma,
Justin Hill
et al.
Abstract:Problematic opioid use that emerges in a subset of individuals may be due to pre-existing disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these mechanisms is not known, but emerging evidence suggests that suboptimal decision-making that is observable prior to drug use may contribute to the pathology of addiction and, notably, serve as a powerful phenotype for interrogating biologically based differences in opiate-taking behaviors. The current study investigated the relations… Show more
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