Sex differences in outcomes of transvenous lead extraction: insights from National Readmission Database

Khalil, Mahmoud; Maqsood, Muhammad Haisum; Maraey, Ahmed; Elzanaty, Ahmed; Saeyeldin, Ayman; Ong, Kenneth; Barbhaiya, Chirag R.; Chinitz, Larry A.; Bernstein, Scott; Shokr, Mohamed

doi:10.1007/s10840-022-01438-z

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…In addition, female patients experienced a significantly higher rate of procedure-related deaths. These findings are consistent with previous studies, including those by Khalil et al, 9 Jachec et al, 4 and Bashir et al, 8 which reported higher complication rates in female patients undergoing TLE. Potential explanations for these disparities include sex differences in venous anatomy, body habitus, and procedural technique.…”

Section: Discussionsupporting

confidence: 93%

“…However, the proportion of female patients with infections was significantly lower than that of male patients. 9 Furthermore, female patients had a higher prevalence of noninfectious indications for TLE. These differences may affect the approach to TLE, including preprocedural planning, patient selection, and postprocedural care.…”

Section: Discussionmentioning

confidence: 99%

“…Sex differences have been reported to influence the outcomes of various cardiovascular procedures, including arrhythmia management and TLE. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 It is pivotal to investigate whether sex differences also play a role in TLE outcomes, because this knowledge could help in optimizing TLE procedures for both male and female patients and could improve overall patient care in the management of CIED-related complications.…”

Section: Introductionmentioning

confidence: 99%

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Transvenous lead extraction: Efficacy and safety of the procedure in female patients

Segreti,

Bongiorni,

Barletta

et al. 2023

Heart Rhythm O2

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transvenous lead extraction: Efficacy and safety of the procedure in female patients

Segreti,

Bongiorni,

Barletta

et al. 2023

Heart Rhythm O2

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Sex differences in long‐term outcomes following transvenous lead extraction

Arabia,

Aboelhassan,

Calvi

et al. 2024

Cardiovasc electrophysiol

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IntroductionTransvenous lead extraction (TLE) is generally considered a safe procedure, albeit not without risks. While gender‐based disparities have been noted in short‐term outcomes following TLE, a notable gap exists in understanding the long‐term consequences of this procedure. The objective of this analysis was to investigate sex differences in both acute and long‐term outcomes among patients who underwent TLE at a tertiary referral center.MethodsIn this retrospective cohort study, consecutive patients who underwent TLE between January 2014 and January 2016 were enrolled. The primary outcome comprised a composite of all‐cause mortality and need for repeated TLE procedures. Secondary outcomes included fluoroscopy time, lead extraction techniques, success rates, and major and minor complications. Results were compared between female and male cohorts.ResultsThe study population comprised 191 patients (median age, 70 years), 29 (15.2%) being women and 162 men (84.8%). Study groups had similar baseline characteristics. Complete procedural success was achieved in 189 out of 191 patients (99.0%), with no significant difference observed between the two groups (p = .17). No major complications were reported in the total cohort. However, there was a significantly higher incidence of minor complications in women compared to men (17.2% vs. 2.5%, p < .01). Following a median follow‐up of 6.5 years, the incidence of the primary composite outcome occurred similarly between the study groups (log‐rank p = .68).ConclusionWomen who underwent TLE exhibited a significantly higher incidence of minor acute intra‐ and peri‐procedural complications than men. However, no differences in long‐term outcomes between genders were observed.

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Sex differences in outcomes of transvenous lead extraction: insights from National Readmission Database

Cited by 2 publications

References 29 publications

Transvenous lead extraction: Efficacy and safety of the procedure in female patients

Transvenous lead extraction: Efficacy and safety of the procedure in female patients

Sex differences in long‐term outcomes following transvenous lead extraction

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