Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior

Ibrahim, Karim; Kalvin, Carla; Li, Fangyong; He, George; Pelphrey, Kevin A.; McCarthy, Gregory; Sukhodolsky, Denis G.

doi:10.1016/j.dcn.2020.100884

Cited by 18 publications

(11 citation statements)

References 110 publications

(128 reference statements)

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“…Supporting the notion that frontoparietal abnormalities are linked to aberrant functioning of the cognitive control network, structural MRI studies have shown reduced gray matter volumes in the ventral PFC ( Rogers and De Brito, 2016 ), as well as reduced cortical thickness and/or gray matter volume in the ventral PFC/orbitofrontal cortex and the supramarginal gyrus/inferior parietal cortex ( Smaragdi et al. , 2017 ; Ibrahim et al. , 2021 ), in children with disruptive behavior disorders relative to unaffected controls.…”

Section: Introductionmentioning

confidence: 93%

Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior

Sukhodolsky

Ibrahim

Kalvin

et al. 2021

Social Cognitive and Affective Neuroscience

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Childhood maladaptive aggression is associated with disrupted functional connectivity within amygdala-prefrontal circuitry. In this study, neural correlates of childhood aggression were probed using the intrinsic connectivity distribution, a voxel-wise metric of global resting state brain connectivity. This sample included 38 children with aggressive behavior (26 boys, 12 girls) ages 8-16 years and 21 healthy controls (14 boys, 6 girls) matched for age and IQ. Functional MRI data were acquired during resting state, and differential patterns of intrinsic functional connectivity were tested in a priori regions-of-interest implicated in the pathophysiology of aggressive behavior. Next, correlational analyses tested for associations between functional connectivity and severity of aggression measured by the Reactive-Proactive Aggression Questionnaire in children with aggression. Children with aggressive behavior showed increased global connectivity in the bilateral amygdala relative to controls. Greater severity of aggressive behavior was associated with decreasing global connectivity in the dorsal anterior cingulate and ventromedial prefrontal cortex. Follow-up seed analysis revealed that aggression was also positively correlated with left amygdala connectivity with the dorsal anterior cingulate, ventromedial and dorsolateral prefrontal cortical regions. These results highlight the potential role of connectivity of the amygdala and medial prefrontal and anterior cingulate cortices in modulating severity of aggressive behavior in treatment seeking children.

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Section: Introductionmentioning

confidence: 93%

Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior

Sukhodolsky

Ibrahim

Kalvin

et al. 2021

Social Cognitive and Affective Neuroscience

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“…Furthermore, although we included female and male participants in our study, the large majority of participants in both patient groups are males. While potentially reflecting the higher prevalence rate among males in both disorders (Loomes et al, 2017; Merikangas et al, 2010), sex differences have been described in both disorders (Fairchild et al, 2013; Ibrahim et al, 2021; Lai & Szatmari, 2020; Napolitano et al, 2022; Ypma et al, 2016). Our supplementary results are also indicative of a potential impact of sex on self‐reported AE, however, given the low numbers of females in the patient groups, results remain preliminary.…”

Section: Discussionmentioning

confidence: 99%

“…To form subgroups of youths with low and high CU traits, we used the clinical cutoff score of 30 as recommended by Docherty et al (2017) for the parent‐rated ICU. Therefore, the patient population was divided into a high ( N = 36 with CU traits ≥30) and a low ( N = 49 with CU traits <30) CU trait subgroup, while the TD group ( N = 45) remained the same (Ibrahim et al, 2021). The models were again separated for empathy scores obtained from either the self‐reported BES or the other‐reported GEM and contained CU subgroups as factor, AE and CE from either the BES or the GEM as regressor, as well as IQ, age, sex, data collection wave, and TIV as covariates.…”

mentioning

confidence: 99%

Empathy deficits, callous‐unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth

Tkalcec,

Bierlein,

Seeger‐Schneider

et al. 2023

Autism Research

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Distinct empathy deficits are often described in patients with conduct disorder (CD) and autism spectrum disorder (ASD) yet their neural underpinnings and the influence of comorbid Callous‐Unemotional (CU) traits are unclear. This study compares the cognitive (CE) and affective empathy (AE) abilities of youth with CD and ASD, their potential neuroanatomical correlates, and the influence of CU traits on empathy. Adolescents and parents/caregivers completed empathy questionnaires (N = 148 adolescents, mean age = 15.16 years) and T1 weighted images were obtained from a subsample (N = 130). Group differences in empathy and the influence of CU traits were investigated using Bayesian analyses and Voxel‐Based Morphometry with Threshold‐Free Cluster Enhancement focusing on regions involved in AE (insula, amygdala, inferior frontal gyrus and cingulate cortex) and CE processes (ventromedial prefrontal cortex, temporoparietal junction, superior temporal gyrus, and precuneus). The ASD group showed lower parent‐reported AE and CE scores and lower self‐reported CE scores while the CD group showed lower parent‐reported CE scores than controls. When accounting for the influence of CU traits no AE deficits in ASD and CE deficits in CD were found, but CE deficits in ASD remained. Across all participants, CU traits were negatively associated with gray matter volumes in anterior cingulate which extends into the mid cingulate, ventromedial prefrontal cortex, and precuneus. Thus, although co‐occurring CU traits have been linked to global empathy deficits in reports and underlying brain structures, its influence on empathy aspects might be disorder‐specific. Investigating the subdimensions of empathy may therefore help to identify disorder‐specific empathy deficits.

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“…Parietal regions are implicated in memory and attention, and are recruited during cognitive control processes along with the ventral prefrontal cortex to modulate limbic reactivity 30,32,33 . Functional and structural MRI studies have shown that perturbations in parietal networks are associated with disruptive behavior in youths 2,3,34,35 , which includes regions of the supramarginal gyrus [34][35][36][37] . Because data-driven, connectomic approaches are advantageous for identifying highly predictive features, such as brain regions and networks, that were not hypothesized a priori, these approaches have potential to advance development of robust and generalizable biomarkers in childhood-onset psychiatric disorders 15,16 .…”

Section: Discussionmentioning

confidence: 99%

Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling

Ibrahim

Noble

et al. 2021

Mol Psychiatry

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Disruptions in frontoparietal networks supporting emotion regulation have been long implicated in maladaptive childhood aggression. However, the association of connectivity between large-scale functional networks in the human connectome with aggressive behavior has not been tested. By using a data-driven, machine learning approach, we show that the functional organization of the connectome during emotion processing predicts severity of aggression in children (n=129). Connectivity predictive of aggression was identi ed within and between large-scale networks implicated in cognitive control (frontoparietal), social functioning (default mode), and emotion processing (subcortical). Out-of-sample replication and generalization of ndings predicting aggression from the functional connectome was conducted in an independent sample of children from the Adolescent Brain Cognitive Development study (n=1,791; n=1,701). These results de ne novel connectivity-based networks of child aggression that can serve as biomarkers to inform targeted treatments for aggression.

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Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior

Abstract: Graphical abstract

Cited by 18 publications

References 110 publications

Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior

Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior

Empathy deficits, callous‐unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth

Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling

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