Sex Differences in Lung Cancer Treatment and Outcomes at a Large Hybrid Academic-Community Practice

Stabellini, Nickolas; Bruno, Débora S.; Dmukauskas, Mantas; Barda, Amie J.; Cao, Lifen; Shanahan, John; Waite, Kristin; Montero, Alberto J.; Barnholtz‐Sloan, Jill S.

doi:10.1016/j.jtocrr.2022.100307

Cited by 26 publications

(42 citation statements)

References 47 publications

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“…The sex differences in lung cancer in our analysis were similar to those of other studies. 9,11,12,25,26 In our current study, the median age at diagnosis and the fact that the median age was lower in women was similar to that of previous studies. 27,28 Intrinsic factors such as sex hormones and multiple exogenous exposures might influence the difference in age at the time of diagnosis between the two sexes.…”

Section: Discussionsupporting

confidence: 91%

“…The sex differences in lung cancer demographics in our analysis were similar to those of other studies 9,11,12,25,26 . In our current study, the median age at diagnosis and the fact that the median age was lower in women was similar to that of previous studies 27,28 .…”

Section: Discussionsupporting

confidence: 91%

“…Contrary to a previous study in which about 70% of women had experienced smoking, 29 our analysis showed only 12.1% of women to be ever‐smokers. This may be the reason for fewer reported cases of squamous cell carcinoma among women in our study, which is closely associated with smoking, compared to that in a previous study 9 . Characteristically, in our study, a higher proportion of women with lung cancer were asymptomatic patients and their performance status was also better.…”

Section: Discussioncontrasting

confidence: 51%

“…The findings of these studies are in concordance with those of our study. In contrast, a United States‐based study using data from a large single center and the Surveillance, Epidemiology, and End Results (SEER) database showed that sex was not a significant prognostic factor after adjusting for confounding factors 9 . Similarly, an Australian prospective cohort study also demonstrated no significant survival difference according to sex after adjustment.…”

Section: Discussionmentioning

confidence: 89%

“…According to previous studies, men had poorer prognosis for lung cancer compared to women 8,9 . However, factors such as age, smoking, clinical staging, and genetic mutation might have influence as confounding factors 10 .…”

Section: Introductionmentioning

confidence: 96%

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Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population

Jeon

Kim

et al. 2022

Thoracic Cancer

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Purpose This study aimed to investigate the differences in characteristics, clinical stages, treatment modalities, and survival outcomes in patients with non‐small‐cell lung cancer (NSCLC) based on sex differences using Korean nationwide registry data. Methods We analyzed the data of 8650 patients diagnosed with NSCLC between 2014 and 2017, obtained from the Korean Association for Lung Cancer Registry (KALC‐R). The Cox proportional hazard model was used to define the differences in survival based on sex. Propensity score matching was used to adjust for differences between men and women. Results Of a total of 10 943 patients, 8650 (79.1%) were diagnosed with NSCLC, of whom 68.7% were men and 31.3% were women. For NSCLC, the median age was higher (69.0 vs. 67.0, p < 0.001) and the proportion of ever‐smokers (84.5% vs. 10.8%, p < 0.001) was higher in men. Adenocarcinoma (55.5% vs. 90.4%, p < 0.001) and stage I NSCLC (26.3% vs. 41.3%, p < 0.001) were more common in women. Survival was significantly lower in men with NSCLC (hazard ratio [HR] 1.493 [95% confidence interval, CI 1.238–1.800], p < 0.001) even after adjusting for meaningful clinical variables, and in the matched cohort (HR 1.339 [1.075–1.667], p = 0.009). Similarly, survival was significantly lower in men with stage IV adenocarcinoma after adjusting for other clinical variables (HR 1.493 [1.238–1.800], p < 0.001) and in the matched cohort (HR 1.339 [1.075–1.667]; p = 0.009). Conclusions Male patients with NSCLC had poorer prognosis, not only after variable adjustments for prognostic factors, but also in the matched cohort.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 96%

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Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population

Jeon

Kim

et al. 2022

Thoracic Cancer

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Sex differences in adults with acute myeloid leukemia and the impact of sex on overall survival

et al. 2022

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Background There is a male predominance of acute myeloid leukemia (AML) incidence, but survival data are conflicting. The objective of this study is to carry out a comprehensive analysis of sex differences in AML, and to investigate the impact of sex disparities in survival. Methods The cohort included patients ≥18 years diagnosed with AML (2010–2022). Demographics, treatment patterns, treatment adverse events, and survival were analyzed. The population was described and compared by sex, and sex‐based risks and associations were obtained via Cox proportional‐hazards regression. Results In total, 1020 AML patients were analyzed (57.4% males), with lower risk of death for females (aHR = 0.41, 95% CI 0.26–0.66). Among females, BMT (aHR = 0.51, 95% CI 0.27–0.97), hospitalization record (aHR = 0.65, 95%CI 0.45–0.93), and higher appointment completion rates (aHR = 0.98, 95% CI 0.98–0.98) were associated with lower risk of death. Overall, and similarly in males, higher age at diagnosis (aHR = 1.03, 95% CI 1.02–1.04) and a TP53 mutation (aHR = 2.24, 95% CI 1.69–2.97) were associated with higher risk of death. Conclusion Sex differences exist in both AML incidence and overall survival. Treatment and health care factors should be addressed by caregivers and public policies developed to reduce mortality rates and mitigate existing sex differences.

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Lung Cancer in Women: The Past, Present, and Future

Florez,

Kiel,

Riano

et al. 2024

Clinical Lung Cancer

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Sex Differences in Lung Cancer Treatment and Outcomes at a Large Hybrid Academic-Community Practice

Cited by 26 publications

References 47 publications

Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population

Sex differences in the characteristics and survival of patients with non‐small‐cell lung cancer: A retrospective analytical study based on real‐world clinical data of the Korean population

Sex differences in adults with acute myeloid leukemia and the impact of sex on overall survival

Lung Cancer in Women: The Past, Present, and Future

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