Sex Differences in Lipid Profile across the Life Span in Patients with Type 2 Diabetes: A Primary Care-Based Study

Ambrož, Martina; Vries, Sieta T. de; Vart, Priya; Dullaart, Robin; Lennep, Jeanine Roeters van; Denig, Petra; Hoogenberg, Klaas

doi:10.3390/jcm10081775

Cited by 6 publications

(6 citation statements)

References 47 publications

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“… 39 Intriguingly, we observed a U-shaped relationship between total cholesterol and breast cancer risk in both the primary and sensitivity analyses, notably for women aged ≥65 years, but unexpectedly for women with a BMI <30 kg/m 2 . Given that total cholesterol increases around age 50 years in women, 21 , 22 we further adjusted the models with age as a continuous variable, and the observed associations remained.…”

Section: Discussionmentioning

confidence: 99%

“… 13 , 15–20 Inconsistent results in the literature possibly result from the use of different age groups, producing inconsistent changes relative to age. 21 , 22 Intriguingly, diabetes per se could also complicate this relationship by inducing quantitative and qualitative changes in serum lipids and lipoproteins. 23–25 Although dyslipidaemia is routinely measured in patients with T2DM, 26 this has been the focus of only one study to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Role of Serum Lipids, Blood Glucose and Blood Pressure in Breast Cancer Risk for Women with Type 2 Diabetes Mellitus

Zhang

Bock

Denig

et al. 2023

CLEP

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Purpose Women with type 2 diabetes mellitus (T2DM) have an increased risk of breast cancer. We aimed to determine the contribution of lipids, glucose and blood pressure to this risk based on the multifactorial nature of T2DM. Patients and Methods This population-based cohort study used data from a Dutch database (the Groningen Initiative to Analyse Type 2 Diabetes Treatment) for the period 2004–2013. The cohort included women diagnosed with T2DM, aged 30–80 years, with no history of breast cancer and with follow-up data for at least 1 year. We used Cox proportional hazards models to estimate the associations of exposures with breast cancer occurrence, reporting adjusted hazard ratios (aHR) with 95% confidence intervals (CI). Exposures of interest included total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, glycated hemoglobin A (HbA1c) and systolic blood pressure (SBP). Results During a median of 4.45 years’ follow-up, 183 of 10,183 included women received a breast cancer diagnosis. We observed U-shaped associations with breast cancer incidence for total cholesterol and HDL-C at baseline. Compared with moderate elevations, women had significantly higher breast cancer risks associated with high total cholesterol (aHR, 95% CI: 1.72, 1.15–2.55) and HDL-C (aHR, 95% CI: 1.74, 1.18–2.58) levels, while low total cholesterol (aHR, 95% CI: 1.43, 0.94–2.19) and HDL-C (aHR, 95% CI: 1.44, 0.95–2.17) levels produced marginal effects without significance. Women with high LDL-C levels more often received a breast cancer diagnosis than those with medium levels (aHR, 95% CI: 1.56, 1.03–2.35). Conclusion This real-world dataset highlights the importance of balancing lipid profiles, particularly total cholesterol and HDL-C. Dysregulation of the lipid profile, not the glucose or blood pressure profiles, may increase the risk of breast cancer in women with T2DM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Serum Lipids, Blood Glucose and Blood Pressure in Breast Cancer Risk for Women with Type 2 Diabetes Mellitus

Zhang

Bock

Denig

et al. 2023

CLEP

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“…Xuewen Wang et al suggested that the network of hormone action might be an important regulator of lipid metabolism [ 24 ]. Martina Ambrož et al suggested that there were significant differences in the lipid profile of type 2 diabetes (T2D) patients between males and females across their lifespan [ 26 ]. However, the lipid profile between males and females in the IPAH patients compared with healthy controls needs further study.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Abnormal Lipid Metabolism on the Occurrence Risk of Idiopathic Pulmonary Arterial Hypertension

Wei,

Zhao,

Kalionis

et al. 2023

IJMS

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The aim was to determine whether lipid molecules can be used as potential biomarkers for idiopathic pulmonary arterial hypertension (IPAH), providing important reference value for early diagnosis and treatment. Liquid chromatography–mass spectrometry-based lipidomic assays allow for the simultaneous detection of a large number of lipids. In this study, lipid profiling was performed on plasma samples from 69 IPAH patients and 30 healthy controls to compare the levels of lipid molecules in the 2 groups of patients, and Cox regression analysis was used to identify meaningful metrics, along with receiver operator characteristic curves to assess the ability of the lipid molecules to predict the risk of disease in patients. Among the 14 lipid subclasses tested, 12 lipid levels were significantly higher in IPAH patients than in healthy controls. Free fatty acids (FFA) and monoacylglycerol (MAG) were significantly different between IPAH patients and healthy controls. Logistic regression analysis showed that FFA (OR: 1.239, 95%CI: 1.101, 1.394, p < 0.0001) and MAG (OR: 3.711, 95%CI: 2.214, 6.221, p < 0.001) were independent predictors of IPAH development. Among the lipid subclasses, FFA and MAG have potential as biomarkers for predicting the pathogenesis of IPAH, which may improve the early diagnosis of IPAH.

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“…Since women with T2D had higher LDL-c and HDL-c levels and lower triglyceride (TG) levels than men with T2D, gender variations in the lipid profile are probably a factor in this [77] .However, it is unclear if these disparities exist across all age groups and whether menopausal state has an impact on them. Given that postmenopausal diabetes women have an atherogenic lipid and pro-inflammatory profile that is higher than that of premenopausal non-diabetic or diabetic women, this is most likely the case [78].…”

Section: Lifestyle Factors Including Intense Exercise and Carbohydrat...mentioning

confidence: 99%

Relationship the Variation of Serum Vaspin and Some Biochemical Parameters Associated with Gender and BMI of Type2 Diabetic Patients

Abdalelah Saleem

2024

Acad. Sci. J.

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Diabetes mellitus is a chronic disorder categorized by rise blood glucose with a disturbance in the use of carbohydrates, fats and proteins resulting from a deficiency in the secretion of the insulin or the action of insulin or both. The current study aimed to estimation of Vaspin and some biochemical parameters included insulin, fasting blood glucose(FBG), HbA1c, urea, creatinine, Triglyceride(TG), Total Cholesterol(TC), High-density lipoprotein (HDL), low density lipoprotein (LDL) and Very low density lipoprotein (VLDL)in blood of type2 diabetic patients, and determining the change of the ratio in patients comparing with healthy people.The serum vaspin level in patients group was significantly lower than that of the healthy subjects (p<0.05). The serum insulin levels in patients were higher than of healthy subjects but without significant differences (p>0.05). There were a significant difference of serum FBG, HbA1c and urea levels in patients compared to controls (p<0.05), while creatinine level was increased non significantly (p>0.05). The levels of TC, TG, LDL and VLDL were elevated significantly in patients when compared with controls (p<0.05), while HDL was diminished non significantly in patients compared to controls. There was no significant links between serum vaspin and insulin concentrations with FBG, HbA1C, CRP, urea, creatinine, TC, TG, LDL, HDL, and VLDL levels. Vaspin had lowest area under curve (AUC 393 .) and sensitivity ( 68.3 ) in ROC curve.

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Sex Differences in Lipid Profile across the Life Span in Patients with Type 2 Diabetes: A Primary Care-Based Study

Cited by 6 publications

References 47 publications

Role of Serum Lipids, Blood Glucose and Blood Pressure in Breast Cancer Risk for Women with Type 2 Diabetes Mellitus

Role of Serum Lipids, Blood Glucose and Blood Pressure in Breast Cancer Risk for Women with Type 2 Diabetes Mellitus

The Impact of Abnormal Lipid Metabolism on the Occurrence Risk of Idiopathic Pulmonary Arterial Hypertension

Relationship the Variation of Serum Vaspin and Some Biochemical Parameters Associated with Gender and BMI of Type2 Diabetic Patients

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