Sex differences in learning and memory in mice: Effects of sequence of testing and cholinergic blockade.

Berger-Sweeney, Joanne; Arnold, Amy C.; Gabeau, Darlene; Mills, Jennifer S.

doi:10.1037/0735-7044.109.5.859

Cited by 100 publications

(48 citation statements)

References 69 publications

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“…In spite of the fact that some studies have shown sex differences in inhibitory avoidance in non-treated animals (e.g. 25), our results (no sex differences) agree with those published by Lamberty and Gower (36) and Berger-Sweeney et al (37). In our laboratory, sex differences in inhibitory However, subtle differences between males and females were present in our study.…”

Section: Discussionsupporting

confidence: 74%

Effects of acute amitriptyline administration on memory, anxiety and activity in male and female mice

Parra

Everss

Monleón

et al. 2002

Neuroscience Res Communica

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SUMMARYThe effects of acute administration of amitriptyline on memory consolidation in male and female CD1 mice were investigated. Three doses of this tricyclic antidepressant (7.5, 15 and 30 .mg/kg) were administered immediately after inhibitory avoidance training. Forty-five minutes after injection, subjects explored the elevated plus-maze for five minutes. Subjects were tested for avoidance twentyfour hours later. Amitriptyline impaired inhibitory avoidance consolidation at doses 7.5, 15 and 30 mg/kg in males, and at doses 7.5 and 30 mg/kg in females. In the elevated plus-maze, amitriptyline had no effect on anxiety (percentage of open arm entries) and induced a dose-dependent impairment of activity (number of closed arm entries). The observed sex differences were limited to subtle stronger effects of amitriptiline in males than in females on inhibitory avoidance. These results indicate that acute amitriptyline administration produces retrograde amnesia on inhibitory avoidance, which does not seem be mediated by anxiolytic effects.

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Section: Discussionsupporting

confidence: 74%

Effects of acute amitriptyline administration on memory, anxiety and activity in male and female mice

Parra

Everss

Monleón

et al. 2002

Neuroscience Res Communica

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“…Thus, our data support an emerging understanding that sexual dimorphism in the brain is not limited to limbic or endocrine areas, but extends into cognitive centers of the brain, including cerebral cortex (see for example, Clarke and Goldman-Rakic, 1989;Desmond and Levey, 1997;Juraska, 1991;McEwen et al, 1997;Toran-Allerand, 1991). Dimorphic cortical structures as well as hippocampal structures may in fact be the substrate for the long observed dimorphisms in the performance of spatially oriented behavioral tasks (Berger-Sweeney et al, 1995;Gaulin and Hoffman, 1988;Halpern, 1992;Williams and Meck, 1991).…”

Section: Figuresupporting

confidence: 69%

Sexually dimorphic responses to neonatal basal forebrain lesions in mice: II. Cortical morphology

Höhmann

Berger-Sweeney

1998

J. Neurobiol.

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Previous studies in the mouse have shown that neonatal lesions to the cholinergic basal forebrain (nBM) areas result in transient cholinergic depletion of neocortex and precipitate altered cortical morphogenesis. Lesion‐induced morphological alterations in cortex persist into adulthood and are accompanied by behavioral changes, including spatial memory deficits. The current study investigated whether neonatal nBM lesions affect male and female mice differently in adulthood. Quantitative morphometry of cortical layer width was employed to assess alterations in cytoarchitecture in neonatally nBM‐lesioned and littermate control mice of both sexes following behavioral testing. Our results showed significant decreases in cortical layer IV and V widths across somato/motor cortex in neonatally nBM lesioned mice of both sexes. Sexually dimorphic responses were observed in cortical layer II/III and total cortical width, limited to the area containing the “barrel cortex” representation of the whisker hairs. In lesioned females, layer II/III and total cortical width were decreased relative to female controls, and in lesioned males, layer II/III was increased relative to controls, whereas total cortical width was unchanged. In male but not female mice we observed significant correlations between decreased widths in layer IV and V and impaired performance on a spatial memory task. The current data further support a role of developing cholinergic cortical afferents in the modulation of cortical morphogenesis and cortical circuits involved in cognitive behaviors. In addition, our observations provide further evidence for sexually dimorphic development and function in cognitive centers of the rodent brain. © 1998 John Wiley & Sons, Inc. J Neurobiol 37: 595–606, 1998

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“…Differences in learning, activity, and anxiety-related behavior between male and female mice from common inbred strains are well documented (Berger-Sweeney et al, 1995;Bolivar et al, 2001;Voikar et al, 2001;Jonasson, 2005). Notably, there are also behavioral and neurochemical differences between hemizygous male and homozygous female fmr1 KO mice Braun, 2001, 2004;Qin et al, 2005).…”

Section: Discussionmentioning

confidence: 98%

Behavioral and Neurochemical Alterations in Mice Lacking the RNA-Binding Protein Translin

Stein¹,

Bergman²,

Fang³

et al. 2006

J. Neurosci.

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Synapse-specific local protein synthesis is thought to be important for neurodevelopment and plasticity and involves neuronal RNAbinding proteins that regulate the transport and translation of dendritically localized transcripts. The best characterized of these RNAbinding proteins is the fragile X mental retardation protein (FMRP). Mutations affecting the expression or function of FMRP cause fragile X syndrome in humans, and targeted deletion of the gene encoding FMRP results in developmental and behavioral alterations in mice. Translin is an RNA-binding protein that regulates mRNA transport and translation in mouse male germ cells and is proposed to play a similar role in neurons. Like FMRP, translin is present in neuronal dendrites, binds dendritically localized RNA, and associates with microtubules and motor proteins. We reported previously the production of viable homozygous translin knock-out mice, which demonstrate altered expression of multiple mRNA transcripts in the brain and mild motor impairments. Here, we report that translin knock-out mice also exhibit sex-specific differences in tests of learning and memory, locomotor activity, anxiety-related behavior, and sensorimotor gating, as well as handling-induced seizures and alterations in monoamine neurotransmitter levels in several forebrain regions. Similar behavioral and neurochemical alterations have been observed in mice lacking FMRP, suggesting that both proteins may act within the same neuronal systems and signaling pathways. Our results in mice indicate that mutations in translin may contribute to fragile X-like syndromes, mental retardation, attention deficit hyperactivity disorder, epilepsy, and autism spectrum disorders in humans.

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Sex differences in learning and memory in mice: Effects of sequence of testing and cholinergic blockade.

Cited by 100 publications

References 69 publications

Effects of acute amitriptyline administration on memory, anxiety and activity in male and female mice

Effects of acute amitriptyline administration on memory, anxiety and activity in male and female mice

Sexually dimorphic responses to neonatal basal forebrain lesions in mice: II. Cortical morphology

Behavioral and Neurochemical Alterations in Mice Lacking the RNA-Binding Protein Translin

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