Sex Differences in In-Hospital Outcomes of Transcatheter Mitral Valve Repair (from a National Database)

Elbadawi, Ayman; Elzeneini, Mohammed; Thakker, Ravi; Mahmoud, Karim; Elgendy, Islam Y.; Megaly, Michael; Hamed, Mohamed; Omer, Mohamed; Chowdhury, Medhat; Ogunbayo, Gbolahan; Kamal, Diaa; Rangassety, Uma; Jneid, Hani; Gilani, Syed Amir; Khalife, Wissam

doi:10.1016/j.amjcard.2020.01.013

Cited by 13 publications

(20 citation statements)

References 16 publications

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“…The initial search yielded 2218 articles, of which 2205 were excluded on the revision of the titles and abstracts. Among the remaining 13 studies, 3 studies were driven from the National Inpatient Sample database, 11,15,16 thus we included the study with the largest sample size. 11 Eleven studies with 24,905 patients were included in the final analysis.…”

Section: Included Studiesmentioning

confidence: 99%

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Sex differences in outcomes of transcatheter edge‐to‐edge repair with MitraClip: A meta‐analysis

Ya’qoub

Gad

Faza³

et al. 2022

Cathet Cardio Intervent

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Background: Transcatheter edge-to-edge repair (TEER) with MitraClip improves outcomes among select patients with moderate-to-severe and severe mitral regurgitation; however, data regarding sex-specific differences in the outcomes among patients undergoing TEER are limited.Methods: An electronic search of the PubMed, Embase, Central, and Web of Science databases for studies comparing sex differences in outcomes among patients undergoing TEER was performed. Summary estimates were primarily conducted using a random-effects model. Results:Eleven studies with a total of 24,905 patients (45.6% women) were included. Women were older and had a lower prevalence of comorbidities, including diabetes, chronic kidney disease, and coronary artery disease. There was no difference in procedural success (odds ratio [OR]: 0.75, 95% confidence interval [CI]: 0.55-1.05) and short-term mortality (i.e., up to 30 days) between women and men

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Section: Included Studiesmentioning

confidence: 99%

“…Few studies have assessed the sex differences in the clinical profile and outcomes of TEER 3–16 . While some studies showed that women and men undergoing TEER do not share a similar clinical profile, studies also showed conflicting findings regarding the outcomes after TEER.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in outcomes of transcatheter edge‐to‐edge repair with MitraClip: A meta‐analysis

Ya’qoub

Gad

Faza³

et al. 2022

Cathet Cardio Intervent

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“…In recent years, partly due to the increases in poor lifestyle choices such as lack of exercise, smoking, drinking, poor eating habits, and excessive social interaction, there has been a significant increase in the level of catecholamines in the young and middle-aged population, which in turn stimulates the coronary arteries and induces narrowed coronary arteries spasms. As a result, the incidence of AMI is increasing year by year (12,13). Although PCI can significantly improve the survival rate of young and middleaged patients with AMI, postoperative functional recovery is not optimal.…”

Section: Discussionmentioning

confidence: 99%

Observation of the effect of a 7-day gradual early functional exercise program in middle-aged and young patients with acute myocardial infarction after percutaneous coronary intervention

Yang¹,

Sun²,

Feng³

et al. 2021

Ann Palliat Med

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Background: Acute myocardial infarction (AMI) is characterized by a critical condition, rapid progression, and a high fatality rate. Percutaneous coronary intervention (PCI) is the treatment of choice for AMI. The purpose of this study was to investigate the efficacy of a 7-day gradual early functional exercise program after PCI in young and middle-aged patients with AMI.Methods: A total of 106 young and middle-aged patients with AMI at the Affiliated Hospital of Jiangnan University from May 2018 to May 2019 were selected and divided into 2 groups according to the random number table method (n=53 per group). Both groups were treated with PCI, and the control group then received routine functional exercises after surgery, whilst the observation group received a 7-day gradual early functional exercise program after surgery. Functional exercise compliance, daily life ability before and after intervention, changes in quality of life, and postoperative complications after 1 year were compared between the 2 groups. Results:The functional exercise compliance of the observation group was significantly higher than that of the control group (P<0.05). The daily living ability of the observation group was also significantly better than that of the control group after the intervention (P<0.05). The physical activity, emotional response, diet, adverse drug reactions, and anxiety medication scores of the observation group after the intervention were lower than those of the control group (P<0.05). Furthermore, the postoperative complications and total complication rate after 1 year in the observation group was lower than the control group (P<0.05). Conclusions:The application of a 7-day gradual early functional exercise program in young and middleaged patients with AMI after PCI can improve functional exercise compliance, daily life ability, quality of life, and reduce the incidence of complications.

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“…[9][10][11] Similarly, sex-related differences were suggested in the uptake and outcomes of other transcatheter valvular therapies. 12,13 Since TS-TMVR is an emerging procedure, it is important to characterize the patient subsets who are at higher risk to undergo TS-TMVR to better select patients who will really benefit from this procedure. However, there is a paucity of data regarding the sex-related differences in the utilization and short-term outcomes after TS-TMVR.…”

Section: Introductionmentioning

confidence: 99%

“…Sex‐related differences in outcomes after MV surgery exist, with worse short‐term outcomes among women compared with men 9–11 . Similarly, sex‐related differences were suggested in the uptake and outcomes of other transcatheter valvular therapies 12,13 . Since TS‐TMVR is an emerging procedure, it is important to characterize the patient subsets who are at higher risk to undergo TS‐TMVR to better select patients who will really benefit from this procedure.…”

Section: Introductionmentioning

confidence: 99%

Sex‐related differences in the trends and outcomes of trans‐septal transcatheter mitral valve replacement: Insights from the National Readmissions Database

Elbadawi

Tan

Sammour

et al. 2022

Cathet Cardio Intervent

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Background There is a paucity of data regarding the sex‐related differences in the trends and outcomes of trans‐septal transcatheter mitral valve replacement (TS‐TMVR). Methods The Nationwide Readmissions Database (2015–2018) was queried for admissions for TS‐TMVR. Propensity matched analysis was conducted to compare outcomes with hospitalizations for TS‐TMVR among women versus men. The main study outcome was in‐hospital mortality. Results Our final analysis included 2063 hospitalizations for TS‐TMVR; of whom, 58.1% were women. The proportion of women among those undergoing TS‐TMVR increased from 50% in 2015 to 60.2% in 2018 (Ptrend = 0.04). Compared with men, women undergoing TS‐TMVR were slightly younger, and had a distinct profile of comorbidities. After matching, there was no significant difference in in‐hospital mortality among women versus men undergoing TS‐TMVR (7.8% vs. 6.1%, OR = 1.30; 95% CI: 0.79–2.13). Subgroup analyzes showed an interaction toward higher mortality with women versus men among patients with CKD (Pinteraction = 0.07). There were no significant differences between women and men in in‐hospital complications or length of stay after TS‐TMVR. Compared with men, women undergoing TS‐TMVR were more likely to be discharged to a nursing facility (17.7% vs. 11.5%, p = 0.01) and had higher rates of 30‐day readmissions (22.4% vs. 13.6%, p = 0.01). Conclusion This nationwide analysis showed an increase in the proportion of women among patients undergoing TS‐TMVR during the study years. There were no differences in in‐hospital mortality, in‐hospital complications, or length of stay between both sexes following TS‐TMVR. Women were more likely to be discharged to nursing facilities and had higher rates of readmission at 30 days even after propensity matching.

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Sex Differences in In-Hospital Outcomes of Transcatheter Mitral Valve Repair (from a National Database)

Cited by 13 publications

References 16 publications

Sex differences in outcomes of transcatheter edge‐to‐edge repair with MitraClip: A meta‐analysis

Sex differences in outcomes of transcatheter edge‐to‐edge repair with MitraClip: A meta‐analysis

Observation of the effect of a 7-day gradual early functional exercise program in middle-aged and young patients with acute myocardial infarction after percutaneous coronary intervention

Sex‐related differences in the trends and outcomes of trans‐septal transcatheter mitral valve replacement: Insights from the National Readmissions Database

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