Sex differences in immunohistochemical expression and capillary density in pancreatic solid pseudopapillary neoplasm

Hirabayashi, Kenichi; Kurokawa, Sachiko; Maruno, Atsuko; Yamada, Misuzu; Kawaguchi, Yoshindo; Nakagohri, Toshio; Mine, Tetsuya; Sugiyama, Tomoko; Tajiri, Takuma; Nakamura, Naoya

doi:10.1016/j.anndiagpath.2015.02.002

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…No extensive lymphatic dissection was required because we only found one patient with lymph node metastasis in our study (the patient was suspected to pancreatic cancer so the lymph nodes (NO. 10,11,18) around the body and tail of the pancreas were dissected)this concurs with the previous findings of Suzuki et al 22 The role of neo-adjuvant or adjuvant chemotherapy, and radiotherapy, in the treatment of SPT is limited, 23,24 but Brunetti et al find an interesting result that a patient diagnosed to SPTP with malignant transformation treated with adjuvant chemotherapy achieved a longduration. 25 In the present study, we found that pancreatic fistulas were the predominant complication (n=21 patients); grade A fistulas were found in 19 patients, while grade B fistulas were found in two patients; we did not identify any grade C fistulas.…”

Section: Discussionsupporting

confidence: 87%

<p>Diagnosis and Surgical Treatment and Pathological Findings of Solid Pseudopapillary Tumor of the Pancreas: A Single-Institution Experience</p>

Guo¹,

Wang²,

Xie³

et al. 2020

CMAR

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Purpose: To investigate the diagnosis, surgical treatment, and pathology of solid pseudopapillary tumors of the pancreas in our institution. Patients and Methods: We retrospectively analyzed the demographic details, clinical features, imaging findings, and pathological findings of 87 patients with a confirmed diagnosis of solid pseudopapillary tumors of the pancreas (SPTP) and underwent surgery in Tongji Hospital of Tongji Medical College, over a period of 8 years from 2011 to 2018. Results: Our study involved a total of 87 patients (16 males and 71 females) with a mean age of 31.3±13.1 years (range: 10-61 years). The main compliant was abdominal pain or discomfort (n=49) and the median tumor size was 58.6±31.7 mm (range: 16-156mm). Tumors were located in the head (27 patients, 31%), the neck (13 patients, 15%), and the body and tail (47 patients, 54%). There were no significant differences between the patients in terms of sex, age, or tumor location. Partial pancreatectomy was performed in 79 patients, enucleation in six patients, and total pancreatectomy in two patients. R0 resection was achieved in 86 patients. The postoperative morbidity was 36.8%, and the main complication was pancreatic fistula. Pathological examination and immunohistochemical markers were used to provide a final diagnosis. The main follow-up period was 46 months (range: 13-97 months). At the end of the follow-up period, 86 patients were alive and had not experienced recurrence; one patient was lost to follow-up. Conclusion: The accurate diagnosis of SPTP is vital. Our data showed that surgical resection is safe and associated with low morbidity and mortality rates. Pathological findings can play an important role in diagnosis and long-term survival.

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Section: Discussionsupporting

confidence: 87%

<p>Diagnosis and Surgical Treatment and Pathological Findings of Solid Pseudopapillary Tumor of the Pancreas: A Single-Institution Experience</p>

Guo¹,

Wang²,

Xie³

et al. 2020

CMAR

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“…Tumor size was reported to be larger in premenopausal than in postmenopausal patients. These findings demonstrate that female hormones, such as estrogen and progesterone, may influence the proliferation of SPT (29). In our study, all our patients were females and had good prognoses.…”

Section: Discussionmentioning

confidence: 62%

Radical resection of the pancreas should not always be necessary in the surgical management of pancreatic solid pseudopapillary tumor in children

Divarcı

Dökümcü²,

Çetingül³

et al. 2017

Turk J Gastroenterol

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Background/Aims: Pancreatic solid pseudopapillary tumor (SPT) is a rare neoplasm in children. In this study, we aimed to present our surgical strategy based on minimal resection by enucleation or limited resection in localized pancreatic SPT. Materials and Methods: We retrospectively analyzed the medical records of children who underwent surgical resection between October 2011 and September 2016. Results: Five female patients with a median age of 15 years (range, 14-17 years) were operated. Tumors were located in the pancreatic head (n=4) or tail (n=1). The median greatest tumor diameter was 9 cm (range, 5-13 cm). All the patients were investigated with MRI before the resection to demonstrate the relationship between the tumor and the main pancreatic duct. Patients underwent enucleation (n=4) for head localization or local distal resection without splenectomy (n=1) at the pancreatic tail. At postoperative follow-up, major pancreatic leakage was observed in two patients and endoscopically treated. Surgical margins were negative in all patients. The median follow-up period was 44 months (range, 2-59 months) and no local recurrence or distant metastasis was observed in the postoperative period. Conclusion: An optimal surgical strategy is still controversial in pancreatic SPT in children. Radical resections such as pancreaticoduodenoctomy or distal pancreatectomy with splenectomy result in loss of pancreatic tissue for endocrine and exocrine functions. Minimal resections such as enucleation or limited pancreatic resection with negative surgical margins should be performed in selected patients with no invasion to the main pancreatic duct or adjacent organs.

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“…They could not observe fibrous capsule and cholesterol clefts in the male tumors, but these histological signs were seen in more than 60% among females. There were slight, but not significant differences regarding the capillary density, but the cystic degenerations or the necrotic areas occurred at the same frequency [15].…”

Section: Pathological Characteristicsmentioning

confidence: 67%

“…Although SPN does occur in females and males, some gender differences are observed. The affected males are usually older, but the tumor size, the location or the clinical symptoms do not differ significantly [3,15].…”

Section: Clinical Findingsmentioning

confidence: 99%

Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

Zalatnai

Kis-Orha

2019

Pathol. Oncol. Res.

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The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putative histogenesis. From diagnostic point of view, the salient histological characteristic findings are analyzed that would help to differentiate it from other, look-alike pancreatic tumors, and suggestions are made about the desirable content of the histological report.

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Sex differences in immunohistochemical expression and capillary density in pancreatic solid pseudopapillary neoplasm

Cited by 17 publications

References 18 publications

<p>Diagnosis and Surgical Treatment and Pathological Findings of Solid Pseudopapillary Tumor of the Pancreas: A Single-Institution Experience</p>

<p>Diagnosis and Surgical Treatment and Pathological Findings of Solid Pseudopapillary Tumor of the Pancreas: A Single-Institution Experience</p>

Radical resection of the pancreas should not always be necessary in the surgical management of pancreatic solid pseudopapillary tumor in children

Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

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