Sex Differences in Heritability of BMI: A Comparative Study of Results from Twin Studies in Eight Countries

Schousboe, Karoline; Willemsen, Gonneke; Kyvik, Kirsten Ohm; Mortensen, Jakob; Boomsma, Dorret I.; Cornes, Belinda K.; Davis, Chayna; Fagnani, Corrado; Hjelmborg, Jacob; Kaprio, Jaakko; Lange, Marlies de; Luciano, Michelle; Martin, Nicholas G.; Pedersen, Nancy L.; Pietiläinen, Kirsi H.; Rissanen, Aila; Saarni, Suoma; Sørensen, Thorkild I A; Baal, G. Caroline M. van; Harris, Jennifer R.

doi:10.1375/136905203770326411

Cited by 259 publications

(213 citation statements)

References 55 publications

(23 reference statements)

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“…The heritability estimates of weight and BMI in SMS 1947 are slightly higher than estimates from a number of twin studies (Schousboe et al, 2003), but similar to others (Pietilainen et al, 1999). Analyses of these traits have been useful to provide a check on the reliability of the mixture distribution methods.…”

Section: Discussionmentioning

confidence: 51%

Large, Consistent Estimates of the Heritability of Cognitive Ability in Two Entire Populations of 11-Year-Old Twins from Scottish Mental Surveys of 1932 and 1947

et al. 2005

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Section: Discussionmentioning

confidence: 51%

Large, Consistent Estimates of the Heritability of Cognitive Ability in Two Entire Populations of 11-Year-Old Twins from Scottish Mental Surveys of 1932 and 1947

et al. 2005

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“…Although fundamental in documenting the current obesity epidemic, 48 use of BMI as a proxy measure for adiposity may misclassify certain children. 49 Our study is also limited by the inclusion of 2 different measurement methods for child height and weight and the fact that maternal report of these variables is considered less reliable than direct measurement.…”

Section: Limitationsmentioning

confidence: 99%

Developmental Trajectories of Body Mass Index in Early Childhood and Their Risk Factors

Pryor

Tremblay²,

Boivin³

et al. 2011

Arch Pediatr Adolesc Med

133

140

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“…Genetic components underlying obesity have been substantiated by family, twin and adoption studies (Hsu et al 2005;Schousboe et al 2003). Heritability ranges from 25 to 40% for family studies and 50-80% for twin studies.…”

Section: Introductionmentioning

confidence: 99%

FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI

et al. 2010

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SNP rs9939609 within the fat mass and obesity associated gene (FTO) is strongly associated with adult body mass index (BMI). However, influences of FTO on longitudinal BMI change from childhood to adulthood have not been examined. Knowledge is limited on FTO, modulating the association between birth weight and longitudinal change of BMI. This longitudinal study examined SNPs of FTO in 658 white subjects from childhood (3-17 years) to adulthood (18-45 years). No significant associations of FTO SNPs with either birth weight or longitudinal BMI over childhood were noted after multiple-test adjustment. However, three SNPs (rs9939609, rs17820875 and rs860713) with different inheritance patterns were identified to be associated with longitudinal BMI over adulthood after Bonferroni adjustment (P = 5.3 × 10(-5), 2.0 × 10(-4) and 0.001). In addition, interactions were discovered between birth weight and SNPs of rs17820875 (P = 0.001) and rs860713 (0.002). A negative association between birth weight and adult BMI were found in risk genotype AG of rs17820875 and GG of rs860713 in contrast to positive associations in other genotypes. These findings led to the conclusion that lower birth weight predisposes to higher adult BMI depending on FTO risk genotypes. Our studies underscore the importance of FTO influences on obesity and provide insights into the evolution of the long-term burden of obesity.

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Sex Differences in Heritability of BMI: A Comparative Study of Results from Twin Studies in Eight Countries

Cited by 259 publications

References 55 publications

Large, Consistent Estimates of the Heritability of Cognitive Ability in Two Entire Populations of 11-Year-Old Twins from Scottish Mental Surveys of 1932 and 1947

Large, Consistent Estimates of the Heritability of Cognitive Ability in Two Entire Populations of 11-Year-Old Twins from Scottish Mental Surveys of 1932 and 1947

Developmental Trajectories of Body Mass Index in Early Childhood and Their Risk Factors

FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI

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