Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study

Dondo, Tatendashe B; Munyombwe, Theresa; Hall, Marlous; Hurdus, Ben; Soloveva, A.; Gerard, Oliver; Aktaa, Suleman; West, Robert; Hall, Alistair S.; Gale, Chris P

doi:10.1136/bmjopen-2022-062508

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…This aligns with ndings from a similar study in England, which found that women had lower health-related quality of life (HRQoL) compared to men among a large cohort of MI survivors, both at baseline and during the 12-month follow-up. Another study utilizing EuroQOL ve dimensions (EQ-5D-3L) questionnaire reported that women had higher impairment levels in mobility, self-care, usual activities, pain/discomfort, and anxiety/depression at each time point [22]. Studies done in India and Ethiopia, also showed that females have been shown to experience lower QoL after MI compared to their male counterparts [23].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life after Myocardial infarction in the Pakistani Population – Insights from a Single-Center Cohort Study

Hassan,

Abbas,

Arshad

et al. 2024

Preprint

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Background: Quality of life (QoL) assessment is essential for optimizing patient care, treatment adjustments, and medical decision-making, particularly in post-Myocardial Infarction (MI) patients, but limited data exists on QOL post MI from Pakistan. This study aimed to assess Quality of Life (QoL and its determinants in the Pakistani population. Methods: A single-center cross-sectional study was conducted at a tertiary care hospital in Karachi, Pakistan. Patients ≥ 18 years with a primary diagnosis of acute MI (ICD 9 codes: 410.0-410.9 and ICD-10 codes: 121.0-121.9) discharged from the Cardiology Service from January 2019 to December 2020 who could be contacted and consented to participate were included. Data was collected from electronic records, and patients were interviewed via phone calls using a validated Urdu version of the WHOQOL-BREF questionnaire. Statistical analysis was performed using non-parametric tests via RStudio (Version 1.4.1717). Results: The final study cohort was 440 patients with a median age of 63 (IQR: 56,72) years, with a male predominance (68.2%). Physical health was the most affected domain. Females, lower income individuals, and those with lower level of education had lower QoL scores in all domains. Diabetes and presence of multiple co-morbidities were associated with lower QoL. Marital and socioeconomic status, along with psychosocial factors were significantly associated with QoL scores. Notably, 62.0% of post-MI patients rated their overall QoL as good (scores of 4-5 on a Likert scale of 1-5). Cronbach's alpha values indicated good internal consistency, with an overall Cronbach's alpha of 0.902. Conclusion: Although a significant proportion of patients post MI in our cohort reported good QoL, several social factors were associated with lower QoL. These factors must be investigated further in discharge planning and post-discharge of patients with MI.

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Section: Discussionmentioning

confidence: 99%

Quality of Life after Myocardial infarction in the Pakistani Population – Insights from a Single-Center Cohort Study

Hassan,

Abbas,

Arshad

et al. 2024

Preprint

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show abstract

“…A previous study revealed that the HRQoL of women is lower than that of men at baseline and 12-month follow-up in patients with myocardial infarction; these results were similar to those of our study. 37 Another study on patients with hypertension revealed that in a group with poor CV health, women had lower HRQoL than men. 38 This may serve as evidence to suggest that women may have lower HRQoL than men when their CV health is poor.…”

Section: Discussionmentioning

confidence: 99%

Variations in health-related quality of life (EQ-5D) associated with cardiovascular health: a cross-sectional study of adults with diabetes in the Korean general population

Jung

2024

BMJ Open

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ObjectivesPrevious studies on the differences in the mechanism and complications of diabetes between men and women have indicated potential sex differences in cardiovascular health, which affect health-related quality of life (HRQoL).DesignA cross-sectional cohort study.SettingTo determine how sex differences can be noticed, acknowledged and applied in clinical practice, we aimed to determine the cardiovascular (CV) health status of men and women with diabetes and its effects on HRQoL.ParticipantsIn total, 2829 individuals with diabetes (1518 men and 1311 women) aged ≥40 years who participated in the Korean National Health and Nutrition Examination Survey from 2013 to 2018 were enrolled.Outcome measuresIndividuals with diabetes were categorised into poor, intermediate and ideal groups based on CV health indicators recommended by the American Heart Association. We used EQ-5D-3L to compare HRQoL scores between the sexes. Multivariable ordinal logistic regression and analysis of covariance were used to analyse the outcome variables.ResultsIn the poor CV health score group, female sex was associated with mobility problems (OR 1.93, 95% CI 1.46 to 2.54), problems with usual activities (OR1.71, 95% CI 1.24 to 2.35), pain/discomfort (OR 1.69, 95% CI 1.32 to 2.16) and anxiety/depression (OR 1.66 95% CI 1.16 to 2.38). In the intermediate and ideal CV health score groups, female sex was associated with pain/discomfort (OR 1.57, 95% CI 1.15 to 2.15). Men had higher EQ-5D index scores in the poor and intermediate CV health score groups than did women.ConclusionsAlthough women tended to have high health-related CV health scores, HRQoL was lower in women than in men, especially in the poor CV health score group and in the pain/discomfort domain.

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“…Various factors may contribute to a lower QoL for women than for men including being older, greater difficulty for older women in receiving care due to absence of a spouse, and greater prevalence of health comorbidities [34][35][36]. The higher prevalence of anxiety/depression among women than among men in the ideal group may be a major factor contributing to a lower QoL among women compared with that found in men [37,38].…”

Section: Plos Onementioning

confidence: 99%

Sex differences in cardiovascular risk factors and quality of life among individuals with hypertension in Korea from 2013 to 2018: A cross-sectional cohort study

Jung

2024

PLoS ONE

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As its prevalence increases and its association with cardiovascular disease and mortality is established, there is a need to improve prevention and management strategies for hypertension. Therefore, we aimed to compare differences in cardiovascular health status between men and women with hypertension defined by systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg, and/or treatment with antihypertensive drugs. The association between cardiovascular health status and health-related quality of life was also evaluated. Additionally, a secondary analysis was performed on the cross-sectional data from 7306 adults with hypertension, ≥40 years of age between 2013 and 2018. Of this sample, 51.2% of patients were women from the Korean National Health and Nutrition Examination Survey. The seven Cardiovascular Health Metrics were used to quantify cardiovascular health status and the 5-dimensional European Quality of Life Questionnaire (EQ-5D) was used to evaluate health-related quality of life. A higher proportion of men than that of women was observed in the poor cardiovascular health score group [total score 0–7], with a higher proportion of women in the intermediate group [total score 8–10] and ideal group [total 11–14] (p<0.0001). The proportion of women in the EQ-5D index was higher than that of men in the poor and intermediate groups (p<0.0001), with no difference in the proportion of men and women in the ideal group (p = 0.1452). Furthermore, specific cardiovascular risk factors were different between men and women: women had lower physical activity level and higher prevalence of high cholesterol (≥200 mg/dl), and men had higher body mass indices and worse diet management. These findings indicate that prevention and management strategies for hypertension and cardiovascular health might need to differ for men and women to improve outcomes.

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Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study

Cited by 4 publications

References 33 publications

Quality of Life after Myocardial infarction in the Pakistani Population – Insights from a Single-Center Cohort Study

Quality of Life after Myocardial infarction in the Pakistani Population – Insights from a Single-Center Cohort Study

Variations in health-related quality of life (EQ-5D) associated with cardiovascular health: a cross-sectional study of adults with diabetes in the Korean general population

Sex differences in cardiovascular risk factors and quality of life among individuals with hypertension in Korea from 2013 to 2018: A cross-sectional cohort study

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