Sex differences in handedness, asymmetry of the Planum Temporale and functional language lateralization

Sommer, Iris; Alemán, André; Somers, Metten; Boks, Marco P.; Kahn, René S.

doi:10.1016/j.brainres.2008.01.003

Cited by 236 publications

(139 citation statements)

References 107 publications

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“…Sexual dimorphism of PT asymmetry has been reported (de Courten-Myers, 1999;Good et al, 2001;Shapleske et al, 1999), but also not found by some studies (Sommer et al, 2008;Wallentin, 2009;Watkins et al, 2001). A sex difference in PT asymmetry would suggest steroid hormone-related genes and pathways as specific candidates for involvement in this asymmetry.…”

Section: Discussionmentioning

confidence: 94%

“…Of interest to researchers of brain lateralization, handedness was not associated with PT asymmetry; we report elsewhere the results of screening over the entire cerebral cortex in relation to handedness (Guadalupe et al, 2014). The largest previous study that did not identify a significant sex effect on PT asymmetry (Sommer et al, 2008) was based on meta-analysis of data from 13 separate studies, representing 807 subjects in total. Publication bias was suggested to have established a sex effect on PT asymmetry in the literature (Sommer et al, 2008).…”

Section: Asymmetry Of the Pt Is Sexually Dimorphicmentioning

confidence: 97%

“…The largest previous study that did not identify a significant sex effect on PT asymmetry (Sommer et al, 2008) was based on meta-analysis of data from 13 separate studies, representing 807 subjects in total. Publication bias was suggested to have established a sex effect on PT asymmetry in the literature (Sommer et al, 2008). Ours is the first study of cerebral cortical asymmetry to have included data from thousands of subjects, while also using relatively uniform methods, and across individually large datasets.…”

Section: Asymmetry Of the Pt Is Sexually Dimorphicmentioning

confidence: 99%

“…However, some studies have not found an effect of sex on PT asymmetry (Watkins et al, 2001), and a meta-analysis of thirteen earlier studies did not find significant evidence for sexual dimorphism of PT asymmetry (Sommer, Aleman, Somers, Boks, & Kahn, 2008). Publication bias was suggested to have established a sex difference of PT asymmetry in the literature (Sommer et al, 2008;Watkins et al, 2001). Furthermore, a recent review concluded that overall results from studies on regional grey matter distribution, using voxel-based morphometry (VBM), indicate no consistent differences between males and females in language-related cortical regions (Wallentin, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Prenatal testosterone levels have also been implicated in language delay in males (Whitehouse et al, 2012). However, some studies have not found an effect of sex on PT asymmetry (Watkins et al, 2001), and a meta-analysis of thirteen earlier studies did not find significant evidence for sexual dimorphism of PT asymmetry (Sommer, Aleman, Somers, Boks, & Kahn, 2008). Publication bias was suggested to have established a sex difference of PT asymmetry in the literature (Sommer et al, 2008;Watkins et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity

Guadalupe

Zwiers

Wittfeld

et al. 2015

Cortex

119

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The genetic determinants of cerebral asymmetries are unknown. Sex differences in asymmetry of the planum temporale, that overlaps Wernicke’s classical language area, have been inconsistently reported. Meta-analysis of previous studies has suggested that publication bias established this sex difference in the literature. Using probabilistic definitions of cortical regions we screened over the cerebral cortex for sexual dimorphisms of asymmetry in 2337 healthy subjects, and found the planum temporale to show the strongest sex-linked asymmetry of all regions, which was supported by two further datasets, and also by analysis with the Freesurfer package that performs automated parcellation of cerebral cortical regions. We performed a genome-wide association scan meta-analysis of planum temporale asymmetry in a pooled sample of 3095 subjects, followed by a candidate-driven approach which measured a significant enrichment of association in genes of the ´steroid hormone receptor activity´ and 'steroid metabolic process' pathways. Variants in the genes and pathways identified may affect the role of the planum temporale in language cognition

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Section: Discussionmentioning

confidence: 94%

Section: Asymmetry Of the Pt Is Sexually Dimorphicmentioning

confidence: 97%

Section: Asymmetry Of the Pt Is Sexually Dimorphicmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity

Guadalupe

Zwiers

Wittfeld

et al. 2015

Cortex

119

View full text Add to dashboard Cite

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Factors Affecting Cortical Representation

Blackburn¹

2019

The Handbook of the Neuroscience of Multilingualism

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Does cerebral lateralization develop? A study using functional transcranial Doppler ultrasound assessing lateralization for language production and visuospatial memory

et al. 2012

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In the majority of people, language production is lateralized to the left cerebral hemisphere and visuospatial skills to the right. However, questions remain as to when, how, and why humans arrive at this division of labor. In this study, we assessed cerebral lateralization for language production and for visuospatial memory using functional transcranial Doppler ultrasound in a group of 60 typically developing children between the ages of six and 16 years. The typical pattern of left-lateralized activation for language production and right-lateralized activation for visuospatial memory was found in the majority of the children (58%). No age-related change in direction or strength of lateralization was found for language production. In contrast, the strength of lateralization (independent of direction) for visuospatial memory function continued to increase with age. In addition, boys showed a trend for stronger right-hemisphere lateralization for visuospatial memory than girls, but there was no gender effect on language laterality. We tested whether having language and visuospatial functions in the same hemisphere was associated with poor cognitive performance and found no evidence for this “functional crowding” hypothesis. We did, however, find that children with left-lateralized language production had higher vocabulary and nonword reading age-adjusted standard scores than other children, regardless of the laterality of visuospatial memory. Thus, a link between language function and left-hemisphere lateralization exists, and cannot be explained in terms of maturational change.

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Sex differences in handedness, asymmetry of the Planum Temporale and functional language lateralization

Cited by 236 publications

References 107 publications

Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity

Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity

Factors Affecting Cortical Representation

Does cerebral lateralization develop? A study using functional transcranial Doppler ultrasound assessing lateralization for language production and visuospatial memory

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