Sex differences in extinction and reinstatement of nicotine discrimination in rats: The effects of reinforcer devaluation.
Adysn Kilty,
Yvonne Lucas,
Caroline Kukas
et al.
Abstract:Nicotine functions effectively as an interoceptive operant discriminative stimulus (SD) that sets the occasion for voluntarily emitted behavior to be reinforced by biologically relevant outcomes (e.g., food). This has been demonstrated primarily with male rats. Far less is known about nicotine’s operant SD functions in female rats. There are no reports of sex differences in extinction and recovery of the SD functions of nicotine, which may elucidate smoking cessation and relapse. In view of this, eight male an… Show more
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