Sex differences in expression and subcellular localization of heart rhythm determinant proteins

Thomas, Neil; Jasmin, Jean François; Lisanti, Michael P.; Iacobaş, Dumitru A.

doi:10.1016/j.bbrc.2011.02.006

Cited by 13 publications

(12 citation statements)

References 41 publications

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“…As ejection delay represents conduction delay, these findings suggest that the predominance of the malignant Brugada phenotype in males [32][33][34] is also the result of a longer RV conduction delay. The reason for this gender based difference could be a reduced Cx43 expression and the increased RV fibrosis, as described in male heterozygous SCN5A-mice [46,47]. However, these preclinical findings cannot be translated to patients directly and need confirmation in clinical studies.…”

Section: Gender-based Differencesmentioning

confidence: 86%

Prolonged right ventricular ejection delay identifies high risk patients and gender differences in Brugada syndrome

Malderen

Kerkhove

Theuns

et al. 2015

International Journal of Cardiology

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Section: Gender-based Differencesmentioning

confidence: 86%

Prolonged right ventricular ejection delay identifies high risk patients and gender differences in Brugada syndrome

Malderen

Kerkhove

Theuns

et al. 2015

International Journal of Cardiology

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“…The collection of the affected genes is unique for each human being because the gathering together of the transcriptomic conditioning factors is never perfectly repeatable. In previous papers, we have shown that the transcriptome depends on genetic background [23], sex [24], age [25], medical history [26], hormonal activity [27], environmental conditions [28], exposure to stress [29], toxins [30], treatment [31], and external stimuli [32]. By evidence, it is impossible to have exactly the same combination of factors and identical influence of a particular factor in distinct individuals.…”

Section: Introductionmentioning

confidence: 99%

Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach

Iacobaş

Mgbemena

Iacobaş

et al. 2020

Cancers

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Published transcriptomic data from surgically removed metastatic clear cell renal cell carcinoma samples were analyzed from the genomic fabric paradigm (GFP) perspective to identify the best targets for gene therapy. GFP considers the transcriptome as a multi-dimensional mathematical object constrained by a dynamic set of expression controls and correlations among genes. Every gene in the chest wall metastasis, two distinct cancer nodules, and the surrounding normal tissue of the right kidney was characterized by three independent measures: average expression level, relative expression variation, and expression correlation with each other gene. The analyses determined the cancer-induced regulation, control, and remodeling of the chemokine and vascular endothelial growth factor (VEGF) signaling, apoptosis, basal transcription factors, cell cycle, oxidative phosphorylation, renal cell carcinoma, and RNA polymerase pathways. Interestingly, the three cancer regions exhibited different transcriptomic organization, suggesting that the gene therapy should not be personalized only for every patient but also for each major cancer nodule. The gene hierarchy was established on the basis of gene commanding height, and the gene master regulators DAPK3,TASOR, FAM27C and ALG13 were identified in each profiled region. We delineated the molecular mechanisms by which TASOR overexpression and ALG13 silencing would selectively affect the cancer cells with little consequences for the normal cells.

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“…The collection of the affected genes is unique for each human because the gathering together of the transcriptomic conditioning factors is never perfectly repeatable. In previous papers we have shown that the transcriptome depends on the: genetic background [21], sex [22], age [23], medical history [24], hormonal activity [25], environmental conditions [26], exposure to stress [27], toxins [28], treatment [29] and external stimuli [30]. By evidence, there is no way to have exactly the same combination of factors or/and identical influences of a particular factor in distinct individuals.…”

Section: Introductionmentioning

confidence: 99%

Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach

Iacobaş

Mgbemena

Iacobaş

et al. 2020

Preprint

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Published transcriptomic data from surgically removed metastatic clear cell renal cell carcinoma (ccRCC) samples were re-analyzed from the Genomic Fabric Perspective that considers the transcriptome a multi-dimensional mathematical object, constrained by a dynamic set of expression correlations among genes. Every gene in the chest wall metastasis (MET), two primary tumors (PTA, PTB) and the surrounding normal tissue (NOR) of the right kidney was characterized by three independent measures: average expression level (AVE), relative expression variation (REV) and expression correlation (COR) with each other gene. AVE was used to determine the regulation of the genomic fabrics of ccRCC, apoptosis, chemokine and VEGF signaling pathways. REV quantified the alteration of the transcripts’ abundances control, while COR determined the remodeling of the transcriptomic networks of chemokine signaling and oxidative phosphorylation genes. The gene hierarchy was established in based on Gene Commanding Height and the Gene Master Regulators (GMR) TASOR (PTA), FAM27C (PTB) and ALG13 (MET) and DAPK3 (NOR) were identified in each profiled region. We predict that TASOR overexpression would block transcription in PTA but not in PTB, while slightly stimulating it in NOR. Silencing of ALG3 would slow-down the cell-cycle in all three cancer regions with practically no effect in NOR.

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Sex differences in expression and subcellular localization of heart rhythm determinant proteins

Cited by 13 publications

References 41 publications

Prolonged right ventricular ejection delay identifies high risk patients and gender differences in Brugada syndrome

Prolonged right ventricular ejection delay identifies high risk patients and gender differences in Brugada syndrome

Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach

Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach

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