Sex differences in exercise efficacy to improve cognition: A systematic review and meta-analysis of randomized controlled trials in older humans

Barha, Cindy K.; Davis, Jennifer C.; Falck, Ryan S.; Nagamatsu, Lindsay S.; Liu-Ambrose, Teresa

doi:10.1016/j.yfrne.2017.04.002

Cited by 305 publications

(318 citation statements)

References 124 publications

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“…Secondly, some researchers warn that the advantages of exercise practice are overstated and sport may itself disturb brain function (eg, compromising mental health), especially when intensively performed . Thirdly, Lynch et al and Barha et al reviewed clinical as well as preclinical data suggesting that physical activity efficacy may depend upon the following parameters: (i) individuals (ie, by age and sex), (ii) drug classes (ie, alcohol vs nicotine and cocaine), (iii) stage of the addiction process, and (iv) the exercise conditions tested.…”

Section: Clinical Evidence For Physical Exercise On Meth Addictionmentioning

confidence: 99%

“…Regarding biological sex, it was argued that women benefited more than men in cognitive outcomes . For example, Colcombe and Kramer presented a meta‐analysis of 18 RCTs showing that the effect of exercise with an aerobic component on cognition was statistically bigger in samples comprising more than 50% women compared with samples of more than 50% men.…”

Section: Clinical Evidence For Physical Exercise On Meth Addictionmentioning

confidence: 99%

“…Regarding biological sex, it was argued that women benefited more than men in cognitive outcomes. 109 For example, Colcombe and…”

Section: Wang Et Al 105mentioning

confidence: 99%

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The neurobiological mechanisms of physical exercise in methamphetamine addiction

et al. 2017

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Methamphetamine (METH) is the primary drug within amphetamine-type stimulants which are the second most abused group of drugs worldwide. There is no pharmacological treatment addressed specifically to METH addiction, and behavioral therapy is shadowed by poor long-term recovery and relapse. Therefore, novel approaches to manage METH addiction are an urgent need. This review aims to describe the current state of physical exercise use on methamphetamine addiction management. The following searching terms in PubMed were used: ("physical exercise" OR "exercise") AND "methamphetamine." Relevant references from key publications and gray literature were also reviewed to identify additional citations for inclusion. Original investigation regarding physical exercise and methamphetamine addiction (clinical data) or neurobiological mechanisms of physical exercise in animal models of methamphetamine administration (preclinical data) was included. Overall, METH users demonstrated improvements, including better fitness and emotional measures, lower relapse rates, and sustained abstinence when compared to nonexercised individuals. The neurobiological mechanisms of physical exercise in METH users seem to reflect an interplay of several agents, including neurochemicals, oxidative stress, neurogenesis, gliogenesis, and blood-brain barrier as disclosed by preclinical data. Exercise-based interventions alone or as a conjoint therapy may be a useful tool for managing METH addiction.

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Section: Clinical Evidence For Physical Exercise On Meth Addictionmentioning

confidence: 99%

Section: Clinical Evidence For Physical Exercise On Meth Addictionmentioning

confidence: 99%

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The neurobiological mechanisms of physical exercise in methamphetamine addiction

et al. 2017

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“…In this regard, it is apparent that sex-dependent variation exists in the effectiveness of exercise, with females influenced somewhat differently than males [3,29]. Interestingly, sex differences in exercise protocol responsiveness have been noted in both older humans [30] and in older rodent models [31].…”

Section: Exercise and Cognition Conditionsmentioning

confidence: 99%

Would Adding Low Doses of Lithium Salts and/or Prebiotic Fibre Interventions to an Effective Exercise Protocol Further Enhance Retention of Cognitive Integrity? Potential for Preventing Loss of Cognition with Aging Using Combinations of Low Cost Regimens

Hart¹

2018

JBiSE

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It is clear that loss of cognition is becoming epidemic in our aging society. Onset of dementia and diseases such as Alzheimer's are very prevalent and the prognosis is not optimistic that numbers will decrease in the coming decades. Thus, this epidemic is impacting the quality of life of a large number of people, primarily females, as well as the health care systems of many countries. Of relevance is the fact that large clinical trials of candidate drugs to treat these conditions have not been overwhelming successes, indicating that we may need to take new directions or focus on prevention. One conservative approach in this regard has been the use of exercise protocols to both retain cognition and inhibit progression of loss. With the optimization of exercise protocols, it may be time to step back and ask "how can these successes be augmented to further inhibit risk and stabilize loss early in the development of these conditions?" An example of how this could be approached is via supplementation with low doses of minerals such as lithium salts, or supplementation of the diet with prebiotics in patients with obesity and metabolic syndrome. Regarding the former, recent epidemiological studies have indicated that the content of Li in the drinking water is associated with lower incidences of cognitive diseases/conditions. While not definitive, such clues may warrant performing controlled studies using low doses of lithium salts plus exer- cise to further optimize impact on retention of cognition in those at risk, or those with early disease. Similarly, patients with obesity are at higher risk to develop dementia, and prebiotics can correct some of the metabolic derangements associated with the microbiome in such patients to impact risk. Thus, multiple low cost interventions plus exercise could further enhance retention of cognitive integrity in specific populations.

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“…Representatively, voluntary aerobic exercise promoted non-spatial memory to a greater extent in males, forced exercise increased hippocampus-dependent learning and memory, and induced heightened levels of BDNF compared controls in male and female participants. 43 Finally, physical exercise exerts an essential influence for the prevention and intervention against age-related cognitive decline and mild cognitive impairment, together with a multitude of neurologic and psychiatric conditions, including type II diabetes, hypertension, heart disease, stroke, osteoporosis, cancers, and obesity with exercise-boosted serum/regional BDNF a major avenue for disorder amelioration.…”

mentioning

confidence: 99%

BDNF Integrity in Ageing and Stress

Archer¹

2017

MOJGG

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Sex differences in exercise efficacy to improve cognition: A systematic review and meta-analysis of randomized controlled trials in older humans

Cited by 305 publications

References 124 publications

The neurobiological mechanisms of physical exercise in methamphetamine addiction

The neurobiological mechanisms of physical exercise in methamphetamine addiction

Would Adding Low Doses of Lithium Salts and/or Prebiotic Fibre Interventions to an Effective Exercise Protocol Further Enhance Retention of Cognitive Integrity? Potential for Preventing Loss of Cognition with Aging Using Combinations of Low Cost Regimens

BDNF Integrity in Ageing and Stress

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