Sex differences in effects of tDCS and language treatments on brain functional connectivity in primary progressive aphasia

Licata, Abigail; Zhao, Yi; Herrmann, Olivia; Hillis, Argye E.; Desmond, John E.; Onyike, Chiadi U.; Tsapkini, Kyrana

doi:10.1016/j.nicl.2023.103329

Cited by 2 publications

(3 citation statements)

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“…The experimental procedures were reviewed and approved by the Institutional Ethics Committee and conducted following the Helsinki Declaration on human research ethics. We decided to include only women in order to have a more homogeneous sample, as there are differences between sexes in terms of neuromodulation [ 34 ], which impact the tDCS-induced electric field on the target area for different montages and current intensities [ 33 ], resulting in different changes in corticospinal excitability [ 35 ], functional connectivity [ 36 ], and clinical findings [ 32 , 37 ] between men and women.…”

Section: Methodsmentioning

confidence: 99%

“…It is worth noting that most of recent studies in this field have been conducted on male participants, showing the necessity of conducting research studies on female participants [32][33][34]. This is important, considering the differences between sexes, with implications for neuromodulation [34], which results in differences between men and women in tDCS-induced electric field, on the target area; for different montages and current intensities [33], changes in corticospinal excitability [35], functional connectivity [36], and clinical findings [32,37]. Therefore, based on the dearth of information regarding the effectiveness of tDCS in sports referees' decision-making performance-in particular female sports referees-and sex-related implications for neuromodulation techniques, the aim of this study was to investigate the effect of tDCS applied over the right DLPFC area on the decision making, impulsivity, and reaction time of female team sports referees.…”

Section: General Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anodal Transcranial Direct Current Stimulation over the Right Dorsolateral Prefrontal Cortex Boosts Decision Making and Functional Impulsivity in Female Sports Referees

Ghayebzadeh

Zardoshtian

Amiri

et al. 2023

Life

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We investigated the effect of anodal transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (rDLPFC) on the sensitive decision making of female team sports referees. Twenty-four female referees voluntarily participated in this randomized, double-blind, crossover, and sham-controlled study. In three different sessions, participants received either anodal (a-tDCS; anode (+) over F4, cathode (−) over the supraorbital region (SO)), cathodal (c-tDCS; −F4/+SO), or sham tDCS (sh-tDCS) in a randomized and counterbalanced order. a-tDCS and c-tDCS were applied with 2 mA for 20 min. In sh-tDCS, the current was turned off after 30 s. Before and after tDCS, participants performed the computerized Iowa Gambling Task (IGT) and Go/No Go impulsivity (IMP) tests. Only a-tDCS improved IGT and IMP scores from pre to post. The delta (Δ = post–pre) analysis showed a significantly higher ΔIGT in a-tDCS compared to c-tDCS (p = 0.02). The ΔIMP was also significantly higher in a-tDCS compared to sh-tDCS (p = 0.01). Finally, the reaction time decreased significantly more in a-tDCS (p = 0.02) and sh-tDCS (p = 0.03) than in c-tDCS. The results suggest that the a-tDCS improved factors related to sensitive decision making in female team sports referees. a-tDCS might be used as an ergogenic aid to enhance decision performance in female team sports referees.

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Section: Methodsmentioning

confidence: 99%

Section: General Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anodal Transcranial Direct Current Stimulation over the Right Dorsolateral Prefrontal Cortex Boosts Decision Making and Functional Impulsivity in Female Sports Referees

Ghayebzadeh

Zardoshtian

Amiri

et al. 2023

Life

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Sex matters for the enhancement of cognitive training with transcranial direct current stimulation (tDCS)

Weller,

Derntl,

Plewnia

2023

Biol Sex Differ

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Background Transcranial direct current stimulation (tDCS) can influence brain network activity and associated cognitive and behavioural functions. In addition to the extensive variety in stimulation parameters, numerous biological factors drive these effects, however these are yet poorly understood. Here, we investigate one of the major biological factors by focusing on sex-dependent effects of tDCS on a challenging cognitive control task (adaptive paced auditory serial addition task [PASAT]) in healthy humans. Methods This sex-specific re-analysis was performed on data of 163 subjects who underwent a 2-week cognitive control training (6 sessions in total). Subjects received either verum (anodal/cathodal) or sham tDCS. Electrodes were placed over the left or right dorsolateral prefrontal cortex and the respective contralateral deltoid muscle. Cognitive control was measured as performance in the PASAT and was analysed in respect to stimulation conditions (sham, anodal, cathodal) and sex. Results Regardless of stimulation condition, performance gains between the sexes were higher in females compared to males (p = 0.0038). Female’s performance during anodal tDCS exceeded male’s (p = 0.0070), yet no effects were found for cathodal or sham tDCS. Moreover, in females we found a superior effect for anodal tDCS over sham stimulation (fanodal: p = 0.0354; fcathodal: p = 0.6181), but no such effect in males (manodal: p = 0.6882; mcathodal: p = 0.4822). Conclusions This study highlights the relevance of biological sex for the effects of tDCS on cognitive training. Thus, an increased attention to biological sex is advisable in future brain stimulation research to highlight and in consequence better understand potentially underlying sex-specific mechanisms. Considering biological sex will further advance customisation and individualisation of tDCS interventions. Trial registration ClinicalTrials.gov, NCT04108663.

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Sex differences in effects of tDCS and language treatments on brain functional connectivity in primary progressive aphasia

Cited by 2 publications

References 66 publications

Anodal Transcranial Direct Current Stimulation over the Right Dorsolateral Prefrontal Cortex Boosts Decision Making and Functional Impulsivity in Female Sports Referees

Anodal Transcranial Direct Current Stimulation over the Right Dorsolateral Prefrontal Cortex Boosts Decision Making and Functional Impulsivity in Female Sports Referees

Sex matters for the enhancement of cognitive training with transcranial direct current stimulation (tDCS)

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