Sex differences in depression, anxiety and health-promoting lifestyles among community residents: A network approach

Zheng, Ziwei; Zhao, Wenqing; Zhou, Qingxiao; Yang, Yang; Chen, Shuangyi; Hu, Jun; Jiang, Wenhui; Zhang, Weibo; Cai, Jun; Qiu, Jianyin

doi:10.1016/j.jad.2023.07.107

Cited by 5 publications

(5 citation statements)

References 77 publications

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“…Currently, gastroscopy is considered the gold standard for diagnosing stomach diseases [18]. However, utilizing serum gastric function en's tendency towards sedentary and inactive lifestyles, highlighting the potential benefits of promoting physical activity for overall mental well-being among women [23]. Second, in this study, compared with the nonanxiety group, patients in the anxiety group had significantly higher PGII values and significantly lower PGR.…”

Section: Discussionmentioning

confidence: 63%

Pepsinogen II and a no-pickled food diet are risk factors for female patients with anxiety: a cross-sectional study

Wang

2024

Am J Transl Res

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Objectives: No studies have evaluated the relationship between lifestyle and Pepsinogen (PG)I, PGII and Gastrin (G)17 in patients with anxiety. Using data from the Affiliated Hospital of Xuzhou Medical University study, we aimed to identify factors associated with anxiety. Methods: We conducted a retrospective cross-sectional observational study involving 779 Chinese healthy checkup participants (301 males; mean age, 47.60±16.17 years) who underwent stomach-related health examinations. Results: Anxiety was defined as a Hamilton Anxiety Scale (HAM-A) Scale score ≥14. The odds ratios, with 95% confidence intervals, were calculated using binary logistic analysis to assess the risk of anxiety and healthy checkup participants while adjusting for several covariates. In the HAM-A≥14 group (anxiety group), sex, PGII and pickled dishes were independent influencing factors. Binary logistic regression analysis revealed a significant difference in anxiety risk between the high PGII group and the low PGII group for females (P=0.005). There was also a significant difference in anxiety risk between the groups consuming pickled and non-pickled food for females (P=0.010). Logistic regression analysis indicated a higher risk of anxiety in females aged ≤50 years who belonged to the high PGII + no pickled foods group. Conclusions: Our study revealed that in females aged ≤50 years, high levels of PGII and no pickled foods were associated with a higher risk of anxiety.

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Section: Discussionmentioning

confidence: 63%

Pepsinogen II and a no-pickled food diet are risk factors for female patients with anxiety: a cross-sectional study

Wang

2024

Am J Transl Res

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“…Besides common medications, adopting a healthy lifestyle can help alleviate depression in adults (Wang W. C. et al, 2022). Sex-specific differences in lifestyle interventions exist, with physical activity showing promise in improving women's overall mental health than men (Zheng et al, 2023). Because low vitamin D levels are linked to higher depression risk, particularly in women, preventing vitamin D deficiency is crucial in mitigating their depression (Hinata et al, 2023).…”

Section: Other Therapiesmentioning

confidence: 99%

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Chen,

Wang,

Liu

et al. 2024

Front. Aging Neurosci.

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Depression and Alzheimer’s disease (AD) are prevalent neuropsychiatric disorders with intriguing epidemiological overlaps. Their interrelation has recently garnered widespread attention. Empirical evidence indicates that depressive disorders significantly contribute to AD risk, and approximately a quarter of AD patients have comorbid major depressive disorder, which underscores the bidirectional link between AD and depression. A growing body of evidence substantiates pervasive sex differences in both AD and depression: both conditions exhibit a higher incidence among women than among men. However, the available literature on this topic is somewhat fragmented, with no comprehensive review that delineates sex disparities in the depression–AD correlation. In this review, we bridge these gaps by summarizing recent progress in understanding sex-based differences in mechanisms, genetics, and therapeutic prospects for depression and AD. Additionally, we outline key challenges in the field, holding potential for improving treatment precision and efficacy tailored to male and female patients’ distinct needs.

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“…Research has underscored that moving beyond simply examining symptom-symptom interactions of psychiatric disorders and considering risk or resilience factors within network models is critical to shed light on the pathway to psychiatric disorders. Furthermore, this approach is required to elucidate the processes that protect against the development of psychopathology and to provide insights into the potential applications that provide targeted treatment ( 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

“…To elucidate which risk or resilience factors have most prominent roles in depression and anxiety symptoms, we detected central and bridge factors in the network. Further, given gender is known to be a significant influencing factor underlying prevalence rates of depression and anxiety ( 21 , 37 ), we investigated potential gender differences in the overall network structure as well as the strength of associations among depression and anxiety symptoms and risk and resilience factors. Ultimately, by considering various individual and environmental factors in tandem with depression and anxiety symptoms, the present study provides important insights into the complex patterns of the interplay of depression and anxiety symptoms with risk and resilience factors, and provides evidence-based and gender-specific health-promoting strategies to reduce psychopathology symptoms and to better support psychological health.…”

Section: Introductionmentioning

confidence: 99%

Mastery is central: an examination of complex interrelationships between physical health, stress and adaptive cognition, and social connection with depression and anxiety symptoms

Shin,

Park

2024

Front. Psychiatry

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BackgroundResearch has established the link between physical health, stress and cognition, and social connection with depression and anxiety. Nevertheless, an understanding of the comorbidity of depression and anxiety symptoms and their complex interrelationships with relevant factors remains still limited. This study investigated the complex pattern of interplay between depression and anxiety symptoms and pertinent physical, cognitive, and social factors and potential gender differences.MethodsUsing a sample of 600 middle-aged men and women, depression and anxiety as well as physical health, perceived stress and mastery, and social connection were assessed. The network structure of depression and anxiety symptoms and risk and resilience factors were characterized by examining interrelationships and the centrality indices of Strength and Bridge Strength. Gender differences were examined using the Network Comparison Test.ResultsPerceived stress and mastery were central bridge factors influencing comorbid depression and anxiety symptoms, and perceived stress, anhedonia, and mastery exhibited strong inter-connections to each other. The connections of physical health-anhedonia and sleep disturbance-irritability were stronger in men than in women, while social connection with family was linked to interpersonal problems only in women.ConclusionsThe results underscore that prevention and interventions targeting reducing perceptions of stress and promoting mastery would prevent onset or recurrence of depression and anxiety symptoms among middle-aged men and women. Engaging in behavioral activities to maintain physical health and ensuring adequate sleep could be particularly beneficial for men in reducing overall symptom severity.

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Sex differences in depression, anxiety and health-promoting lifestyles among community residents: A network approach

Cited by 5 publications

References 77 publications

Pepsinogen II and a no-pickled food diet are risk factors for female patients with anxiety: a cross-sectional study

Pepsinogen II and a no-pickled food diet are risk factors for female patients with anxiety: a cross-sectional study

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Mastery is central: an examination of complex interrelationships between physical health, stress and adaptive cognition, and social connection with depression and anxiety symptoms

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