Sex Differences in Chondrocyte Maturation in the Mandibular Condyle from a Decreased Occlusal Loading Model

Chen, J.; Sobue, Takanori; Utreja, Achint; Kalajzić, Žana; Xu, Manshan; Kilts, Tina M.; Young, Marian F.; Wadhwa, Sunil

doi:10.1007/s00223-011-9498-9

Cited by 21 publications

(28 citation statements)

References 39 publications

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“…Dental occlusion is most important in the modulation of biomechanical loading on TMJs 39 and dietary loading is often considered as an important functional stimulation to TMJ remodeling 4,5,9,10 . Unilateral removal of teeth led to mandibular condylar cartilage thickening and sulfated glycosaminoglycans elevation 13 .…”

Section: Discussionmentioning

confidence: 99%

“…The fact that the small-size diet experimental group showed a lower level of decreasing condyle cartilage thickness, lower degraded cartilage areas, lower expression of ADAMTS-5 and less loss of the cartilage matrix and subchondral bone resorption, agrees with this assumption. It has been reported that although the soft diet plays a negative role in condyle development 5,9,10 , rabbits or rats that received TMJ discectomy had less degenerative cartilage changes 43,44 and higher condylar cartilage sulfate uptake 45 when fed with soft diet. Besides catabolic changes, the chondrocytes in mechanically induced degraded articular cartilage displayed the reparative capability, including the activities of phagocytizing dead cells 46 and proliferation 26,33,36,37 .…”

Section: Discussionmentioning

confidence: 99%

“…Growing rats on soft diet showed thinning cartilage, enhanced cartilage catabolic activity and decreased subchondral bone volume fraction in condyles 6–8 . 3-week-old female mice with trimmed incisors and soft diet for 4 weeks showed reductions in not only the cartilage thickness, but also the subchondral bone volume fraction and trabecular thickness in TMJs 9,10 .…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis

Liu

Liao

Zhang

et al. 2014

Osteoarthritis and Cartilage

108

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Objective Dietary loading has been reported to have an effect on temporomandibular joint (TMJ) remodeling via periodontal-muscular reflex. We therefore examined whether reducing dietary loading decreased TMJ degradation induced by the unilateral anterior crossbite prosthesis as we recently reported. Methods Forty 6-week-old female C57BL/6J mice were randomly divided into two experimental and two control groups. One experimental and one control group received small-size diet and the other two groups received large-size diet. Unilateral anterior crossbite prosthesis was created in the two experimental groups. The TMJ samples were collected 3 weeks after experimental operation. Histological changes in condylar cartilage and subchondral bone were assessed by Hematoxylin & Eosin, toluidine blue, Safranin O and tartrate-resistant acid phosphatase staining. Real-time polymerase chain reaction (PCR) and/or immunohistochemistry were performed to evaluate the expression levels of Collagen II, Aggrecan, a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) and RANKL/RANK/OPG in TMJ condylar cartilage and/or subchondral bone. Results Thinner and degraded cartilage, reduced cartilage cellular density, decreased expression levels of Collagen II and Aggrecan, loss of subchondral bone and enhanced osteoclast activity were observed in TMJs of both experimental groups. However, the cartilage degradation phenotype was less severe and cartilage ADAMTS-5 mRNA was lower while OPG/RANKL ratio in cartilage and subchondral bone was higher in the small-size than large-size diet experimental group. No differences of histomorphology and the tested molecules were found between the two control groups. Conclusions The current findings suggest that a lower level of functional loading by providing small-size diet could reduce TMJ degradation induced by the biomechanical stimulation from abnormal occlusion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis

Liu

Liao

Zhang

et al. 2014

Osteoarthritis and Cartilage

108

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“…De hecho, otro estudio de Saccucci et al (2012b) determino que el tamaño y volumen condilar son significativamente diferentes en sujetos clase I, clase II y clase III lo cual puede generar la discusión sobre el papel que cumple el cóndilo en la consecutiva deformidad facial; así, el cóndilo seria capaz de generar o potenciar cierto tipo de deformidades, mientras que por otra parte, las condiciones funcionales podrían acentuar también patologías condilares como en situaciones donde la reducción de la carga oclusal permite la disminución del volumen óseo condilar en ambos sexos y la disminución de la maduración de condrocitos exclusivamente en mujeres (Chen et al 2011). Esta información redunda en una relación de causa y efecto que podría ser bidireccional en la relación de la deformidad facial y el cóndilo mandibular.…”

Section: Discussionunclassified

Relación Entre el Tamaño Condilar y la Asimetría Facial Transversal en Individuos con Hiperplasia Condilar

Olate¹,

Cantín²,

Alister³

et al. 2013

Int. J. Morphol.

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RESUMEN:La asimetría facial es una patología de compromiso funcional y estético que puede estar generado por hiperplasia condilar; el objetivo de esta investigación es determinar la influencia del tamaño condilar en la asimetría facial. Doce sujetos fueron estudiados mediante el análisis de tomografía computadorizada cone beam; todos los pacientes presentaron cintigrama óseo que determino la presencia de hiperplasia condilar activa; el análisis se realizo en un software del sistema de captura modelo Pax Zenith, marca Vatech (Korea 2011), utilizando 90 kV y 120 mA; se obtuvo mediciones de la distancia antero-posterior, superior-inferior y medio-lateral de la cabeza del cóndilo, relacionándose con la posición del cóndilo con la línea mediana facial y la posición de puntos faciales entre incisivos centrales superior e inferior así como con el mentón. Los resultados mostraron un promedio de desvío de mentón de 6,5 mm considerando un cóndilo hiperplásico con un tamaño de 2,7 mm mas que los cóndilos normales. El desvío de incisivo central inferior determinó que por cada 1 mm de desvío dentario existe 2,2 mm de desvío de mentón. El cóndilo hiperplásico fue de mayor tamaño y se posiciono casi 2 mm mas hacia lateral que los cóndilos no hiperplásicos. Es posible concluir que el cóndilo hiperplásico presenta clara influencia en la asimetría facial transversa y es posible estimar una relación de tamaño condilar con grado de asimetría facial. PALABRA CLAVE: Asimetría facial, Hiperplasia codilar, Deformidad facial INTRODUCCIÓNLa asimetría facial es una patología de origen variado y responde a diferentes condiciones como trauma, infecciones, malformaciones o deformidades (Pirttiniemi, 1994). Buena parte de las asimetrías faciales se vinculan a la patología condilar de crecimiento excesivo o a la reabsorción unilateral de un cóndilo mandibular lo que genera la disminución de la altura facial posterior unilateral, desvío de mentón y la consecuente asimetría facial (Nitzan et al., 2008 ).La hiperplasia condilar (HC) es causante de al menos el 50% de las asimetrías faciales (Saridin et al., 2009) de forma que su estudio es necesario para identificar elementos causantes de la asimetría mandibular y posteriormente la asimetría facial. La HC tiene una fisiopatología controversial y aun no existen datos concluyentes respecto de su evolución (Olate & de Moraes, 2012); aún así, se estima que es mas prevalente en mujeres de entre 15 y 24 años de edad (Raijmakers et al., 2012) aunque cualquier individuo puede ser comprometido en la enfermedad y a cualquier edad (Nitzan et al .).Existen limitados estudios morfológicos que relacionan las características morfológicas de cóndilos con HC activa y las características faciales; es claro que la asimetría resultante se relaciona con la gravedad de la HC (Obwegeser & Makek, 1986) pero aun no existen datos cuantificados al respecto. La clasificación de la morfología facial asociada a HC de Obwegeser & Makek ha sido utilizada consistentemente para identificar características de la enfermedad y se ha...

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“…Utilizing this model, we have observed a decrease in MCC thickness in both male and female mice in response to this underloading treatment 25–27 . Surprisingly, DOL reduced collagen type II (Col2) expression only in females, suggesting sex differences in the role estradiol plays in load altered load-induced MCC chondrogenesis 25, 26 . Estrogen-mediated sex differences have been previously observed in periosteal-derived tissue.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading

Robinson

Cass

Aronson

et al. 2017

Osteoarthritis and Cartilage

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Objective Temporomandibular joint (TMJ) diseases predominantly afflict women, suggesting a role of estrogen in the disease etiology. Previously, we determined that decreased occlusal loading (DOL) inhibited collagen type II (Col2) expression in the mandibular condylar cartilage (MCC) of female wild-type (WT) mice whereas no change was observed in males. This decrease in chondrogenesis was abolished by estrogen receptor beta (ERβ) deficiency in females. Therefore, the goal of this study was to examine the role of estradiol – ERβ signaling in mediating DOL effects in male mice to further decipher sex differences. Methods Male 21 day-old WT and ERβKO male mice were treated with either placebo or estradiol and exposed to normal or DOL for 4 weeks. Cartilage thickness and cell proliferation, gene expression and immunohistochemistry of chondrogenic markers and estrogen receptor alpha (ERα), and analysis of bone histomorphometry via microCT were completed to ascertain the effect of estradiol on DOL effects to the TMJ. Results ERβKO male mice lack a MCC phenotype. In both genotypes, estradiol treatment increased Col2 gene expression and trabecular thickness. DOL in combination with estradiol treatment caused a significant increase in Col2 gene expression in both genotypes. Conclusions The sex differences in DOL-induced inhibition of Col2 expression do not appear to be mediated by differences in estradiol levels between male and female mice. Greater understanding on the role of estrogen and altered loading are critical in order to decipher the sex dimorphism of TMJ disorders.

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Sex Differences in Chondrocyte Maturation in the Mandibular Condyle from a Decreased Occlusal Loading Model

Cited by 21 publications

References 39 publications

Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis

Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis

Relación Entre el Tamaño Condilar y la Asimetría Facial Transversal en Individuos con Hiperplasia Condilar

Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading

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