Sex Differences in Cerebral Blood Flow Associated with a History of Concussion

Hamer, Julia; Churchill, Nathan W.; Hutchison, Michael; Graham, Simon J.; Schweizer, Tom A.

doi:10.1089/neu.2019.6800

Cited by 34 publications

(35 citation statements)

References 55 publications

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“…Nevertheless, the association of the cerebellum with cognitive impairment after mTBI has not been substantially elucidated and needs to be corroborated in future studies. In line with previous findings [8,15], we also identified increased CBF in the bilateral ITG in acute mTBI patients. The ITG is involved in the processes of multimodal sensory integration and visual perception and has been demonstrated volumetric atrophy in mTBI [35].…”

Section: Discussionsupporting

confidence: 93%

“…Using this technique, the alterations of CBF in TBI have been explored in animal models [12] and human studies [13], but few studies focused on mTBI, especially the acute mTBI. Recently, chronic TBI [13] and chronic mTBI [14,15] studies confirmed that the relative disturbances of regional CBF were successfully detected by ASL. Furthermore, Ge et al attempted to evaluate regional CBF changes after chronic mTBI by a resting-state ASL and found significant reductions in mean bilateral thalamic CBF, which was significantly correlated with the simultaneous neuropsychological tests, including measures of learning and memory, response and processing speed, and executive function and verbal fluency [16].…”

Section: Introductionmentioning

confidence: 81%

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Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Shang

et al. 2020

Neural Plasticity

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Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 81%

Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Shang

et al. 2020

Neural Plasticity

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“…This group also used resting and task-based ASL sequences to detect occipital and temporal hypoperfusion in 2012 in a cohort of 21 moderate-severe TBI patients (27). CBF remains abnormal into the chronic phase (28)(29)(30)(31)(32), and has been associated cognitive performance (27), symptom severity (32) and recovery (30).…”

Section: Introductionmentioning

confidence: 99%

Cerebral Perfusion Effects of Cognitive Training and Transcranial Direct Current Stimulation in Mild-Moderate TBI

et al. 2020

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Background: Persistent post-traumatic symptoms (PPS) after traumatic brain injury (TBI) can lead to significant chronic functional impairment. Pseudocontinuous arterial spin labeling (pCASL) has been used in multiple studies to explore changes in cerebral blood flow (CBF) that may result in acute and chronic TBI, and is a promising neuroimaging modality for assessing response to therapies. Methods: Twenty-four subjects with chronic mild-moderate TBI (mmTBI) were enrolled in a pilot study of 10 days of computerized executive function training combined with active or sham anodal transcranial direct current stimulation (tDCS) for treatment of cognitive PPS. Behavioral surveys, neuropsychological testing, and magnetic resonance imaging (MRI) with pCASL sequences to assess global and regional CBF were obtained before and after the training protocol. Results: Robust improvements in depression, anxiety, complex attention, and executive function were seen in both active and sham groups between the baseline and post-treatment visits. Global CBF decreased over time, with differences in regional CBF noted in the right inferior frontal gyrus (IFG). Active stimulation was associated with static or increased CBF in the right IFG, whereas sham was associated with reduced CBF. Neuropsychological performance and behavioral symptoms were not associated with changes in CBF. Discussion: The current study suggests a complex picture between mmTBI, cerebral perfusion, and recovery. Changes in CBF may result from physiologic effect of the intervention, compensatory neural mechanisms, or confounding factors. Limitations include a small sample size and heterogenous injury sample, but these findings suggest promising directions for future studies of cognitive training paradigms in mmTBI.

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“…In humans it has been proposed that these differences may be related to neck girth (43), hormonal influences (44), and cerebral blood flow and metabolic differences (45). Additionally, recent work by Dumais et al (46) found that males and females have a difference in activation of the default mode network, and the dorsal attention network when exposed to punishment and reward;…”

Section: Discussionmentioning

confidence: 99%

A comparison of cognitive-motor integration performance and resting state functional brain network connectivity in female athletes suggests intact motor network and visuomotor skill in those with a concussion history

Pierias

Gorbet

Wójtowicz

et al. 2020

Preprint

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Structural neural changes following concussion are often not captured by standard imaging techniques. However, there is growing evidence that damage to white matter tracts and change in functional network connectivity may be observed following concussive injury. We investigated behavioural performance on a cognitive-motor integration (CMI) task in conjunction with alterations in resting state functional connectivity (rs-FC) in brain networks in a population of 30 female varsity athletes, with 16 having a previous history of concussion. Behavioural performance on accuracy, timing, and trajectory measures of a CMI task were assessed between the concussion history group and the control group. Rs-FC within the nodes of the Default Mode Network (DMN), Dorsal Attention Network (DAN), the Frontoparietal Network, and the Anterior Cerebellar Lobule Network, was assessed against performance scores on accuracy, timing, and trajectory measures. Main findings indicate no difference in behavioural performance between those with concussion history and those without, in contrast to previous findings in a group of primarily male varsity athletes. In addition, no difference in rs-FC was noted in correlation with behavioural performance scores on either accuracy, timing, or trajectory. These findings may suggest sex-related differences in performance on a CMI task, and a resiliency in both functional network connectivity and visuomotor skilled performance in varsity female athletes.

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Sex Differences in Cerebral Blood Flow Associated with a History of Concussion

Cited by 34 publications

References 55 publications

Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Cerebral Perfusion Effects of Cognitive Training and Transcranial Direct Current Stimulation in Mild-Moderate TBI

A comparison of cognitive-motor integration performance and resting state functional brain network connectivity in female athletes suggests intact motor network and visuomotor skill in those with a concussion history

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