Sex Differences in Blood Pressure of Dogs

Liere, Edward J. Van; Stickney, J. Clifford; Marsh, David F.

doi:10.1126/science.109.2837.489

Cited by 13 publications

(10 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The age, 3–5 months (12–20 weeks), is the most common range for studies to be conducted in mice. Moreover, the sex difference in resting arterial pressure, in the order of ~5 mmHg, is consistent with previous reports in mice and other mammalian species, including humans (mice [36], rats [31], rabbits [30], sheep [23], dogs [37], and human [12]). However, not all studies have detected a sex difference in arterial pressure.…”

Section: Discussionsupporting

confidence: 90%

Sex- and age-related differences in arterial pressure and albuminuria in mice

2016

View full text Add to dashboard Cite

BackgroundAnimal models have become valuable experimental tools for understanding the pathophysiology and therapeutic interventions in cardiovascular disease. Yet to date, few studies document the age- and sex-related differences in arterial pressure, circadian rhythm, and renal function in normotensive mice under basal conditions, across the life span. We hypothesized that mice display similar sex- and age-related differences in arterial pressure and renal function to humans.MethodsMean arterial pressure (MAP) and circadian rhythm of arterial pressure were measured over 3 days via radiotelemetry, in 3- and 5-month-old (adult) and 14- and 18-month-old (aged) FVB/N and in 5-month-old (adult) C57BL/6 male and female normotensive mice. In FVB/N mice, albuminuria from 24-h urine samples as well as body, heart, and kidney weights were measured at each age.ResultsTwenty-four-hour MAP was greater in males than females at 3, 5, and 14 months of age. A similar sex difference in arterial pressure was observed in C57BL/6 mice at 5 months of age. In FVB/N mice, 24-h MAP increased with age, with females displaying a greater increase between 3 and 18 months of age than males, such that MAP was no longer different between the sexes at 18 months of age. A circadian pattern was observed in arterial pressure, heart rate, and locomotor activity, with values for each greater during the active (night/dark) than the inactive (day/light) period. The night-day dip in MAP was greater in males and increased with age in both sexes. Albuminuria was greater in males than females, increased with age in both sexes, and rose to a greater level in males than females at 18 months of age.ConclusionsArterial pressure and albuminuria increase in an age- and sex-specific manner in mice, similar to patterns observed in humans. Thus, mice represent a useful model for studying age and sex differences in the regulation of arterial pressure and renal disease. Understanding the mechanisms that underlie the pathophysiology of cardiovascular disease may lead to new and better-tailored therapies for men and women.

show abstract

Section: Discussionsupporting

confidence: 90%

Sex- and age-related differences in arterial pressure and albuminuria in mice

2016

View full text Add to dashboard Cite

show abstract

“…9, where phenotypes of HF are solely determined by volumetric criteria. Besides studying cardiac patients, it is relevant to characterize healthy individuals, and establish reference values for ventricular dimensions for males and females, similar to what has been done in the past regarding "normal" blood pressure (18,21). We found significant sex-specific differences not only for ESVi and EDVi, but also for the most popular metric to assess systolic function, namely EF.…”

Section: Discussionsupporting

confidence: 67%

“…It is well-known that the size of the healthy heart depends on age and dimensions of the animal or human under consideration. In contrast to ventricular volume, it is found in all healthy organisms that arterial blood pressure at resting con-ditions is nearly constant across species, although consistently being slightly lower in adult healthy females (18,21). There are only a few exceptions (such as giraffe and greyhound) with a significantly higher arterial pressure, even at rest.…”

Section: Introductionmentioning

confidence: 93%

Left ventricular volume analysis as a basic tool to describe cardiac function

Kerkhof¹,

Kuznetsova

Ali³

et al. 2018

Advances in Physiology Education

View full text Add to dashboard Cite

The heart is often regarded as a compression pump. Therefore, determination of pressure and volume is essential for cardiac function analysis. Traditionally, ventricular performance was described in terms of the Starling curve, i.e., output related to input. This view is based on two variables (namely, stroke volume and end-diastolic volume), often studied in the isolated (i.e., denervated) heart, and has dominated the interpretation of cardiac mechanics over the last century. The ratio of the prevailing coordinates within that paradigm is termed ejection fraction (EF), which is the popular metric routinely used in the clinic. Here we present an insightful alternative approach while describing volume regulation by relating end-systolic volume (ESV) to end-diastolic volume. This route obviates the undesired use of metrics derived from differences or ratios, as employed in previous models. We illustrate basic principles concerning ventricular volume regulation by data obtained from intact animal experiments and collected in healthy humans. Special attention is given to sex-specific differences. The method can be applied to the dynamics of a single heart and to an ensemble of individuals. Group analysis allows for stratification regarding sex, age, medication, and additional clinically relevant covariates. A straightforward procedure derives the relationship between EF and ESV and describes myocardial oxygen consumption in terms of ESV. This representation enhances insight and reduces the impact of the metric EF, in favor of the end-systolic elastance concept advanced 4 decades ago.

show abstract

“…Similarly, female animals (Van Liere et al , 1949; Ruiz-Feria et al , 2004) tend to have lower arterial BP compared with males. Young women also tend to have lower MSNA (Matsukawa et al , 1998; Narkiewicz et al , 2005), thus the autonomic nervous system may explain, in part, the lower baseline BP values in young women.…”

Section: Sex Differences and Control Of Blood Pressure In Young Adultsmentioning

confidence: 98%

Sex‐specific factors regulating pressure and flow

Barnes

2017

Experimental Physiology

View full text Add to dashboard Cite

Over the last decade, there have been many published reports on sex differences in blood pressure regulation between young men and young women. The autonomic nervous system is a primary contributor to both acute and long-term blood pressure regulation. Sex differences in blood pressure regulation likely have effects that extend beyond mean arterial pressure, and which can affect blood flow and tissue function. This short review will include recent literature from our laboratory focusing on autonomic control of the circulation, specifically age and sex hormone related differences in central hemodynamics and cerebral blood flow, and discuss potential clinical implications.

show abstract

Sex Differences in Blood Pressure of Dogs

Cited by 13 publications

References 2 publications

Sex- and age-related differences in arterial pressure and albuminuria in mice

Sex- and age-related differences in arterial pressure and albuminuria in mice

Left ventricular volume analysis as a basic tool to describe cardiac function

Sex‐specific factors regulating pressure and flow

Contact Info

Product

Resources

About