Sex differences in auditory processing vary across estrous cycle

Krizman, Jennifer; Rotondo, Elena K.; Nicol, Trent; Kraus, Nina; Bieszczad, Kasia M.

doi:10.1038/s41598-021-02272-5

Cited by 18 publications

(10 citation statements)

References 37 publications

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“…Furthermore, previous methods developed by our group to assess at behavioral and electrophysiological levels the impact of permanent ischemia were developed in male mice [30]. Due to these premises and the controversial aspects found in the literature regarding the influence of sex due to hormonal differences (such as estrogen) in the variability of neurological responses [68], we focused this work on an analysis of one single gender to prevent a possible bias in effects non-related to the variables of study. Nevertheless, additional work can provide further information on the opportunities that 2-APB can bring to neuroprotect females after permanent ischemia.…”

Section: Discussionmentioning

confidence: 99%

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Fernández-Serra

Martínez‐Alonso

Alcázar

et al. 2022

IJMS

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Brain stroke is a highly prevalent pathology and a main cause of disability among older adults. If not promptly treated with recanalization therapies, primary and secondary mechanisms of injury contribute to an increase in the lesion, enhancing neurological deficits. Targeting excitotoxicity and oxidative stress are very promising approaches, but only a few compounds have reached the clinic with relatively good positive outcomes. The exploration of novel targets might overcome the lack of clinical translation of previous efficient preclinical neuroprotective treatments. In this study, we examined the neuroprotective properties of 2-aminoethoxydiphenyl borate (2-APB), a molecule that interferes with intracellular calcium dynamics by the antagonization of several channels and receptors. In a permanent model of cerebral ischemia, we showed that 2-APB reduces the extent of the damage and preserves the functionality of the cortical territory, as evaluated by somatosensory evoked potentials (SSEPs). While in this permanent ischemia model, the neuroprotective effect exerted by the antioxidant scavenger cholesteronitrone F2 was associated with a reduction in reactive oxygen species (ROS) and better neuronal survival in the penumbra, 2-APB did not modify the inflammatory response or decrease the content of ROS and was mostly associated with a shortening of peri-infarct depolarizations, which translated into better cerebral blood perfusion in the penumbra. Our study highlights the potential of 2-APB to target spreading depolarization events and their associated inverse hemodynamic changes, which mainly contribute to extension of the area of lesion in cerebrovascular pathologies.

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Section: Discussionmentioning

confidence: 99%

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Fernández-Serra

Martínez‐Alonso

Alcázar

et al. 2022

IJMS

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“…Although there was a main effect of athlete status on harmonic encoding, there was also an interaction between sex and athlete status, with post-hoc tests showing the enhancement was greatest for female athletes. Notably, harmonic encoding is the aspect of auditory processing most strongly tethered to hormone levels, with the greatest harmonic encoding occurring in female rodents when estrogen levels were highest 8 . Consistent with other studies finding that estrogen can lead to sex-specific enhancements in sensory processing 36 , 37 , 46 , estrogen may mediate the pronounced harmonic encoding enhancements seen in female athletes.…”

Section: Discussionmentioning

confidence: 99%

“…The frequency-following response (FFR) was elicited by a synthesized speech sound 80 , ‘da’, described previously in detail 1 , 8 . Briefly, the ‘da’ is 40-ms in duration, beginning with a noise burst, followed by a formant transition between the ‘d’ and the ‘a’.…”

Section: Methodsmentioning

confidence: 99%

“…The female brain responds to sounds faster and more robustly than males [1][2][3] . Animal models suggest that these sex differences in auditory processing are tied to hormone levels in females [4][5][6][7] , with the greatest differences occurring when female estrogen levels are highest 8 . Consistent with a tethering of hormone levels and auditory processing, in humans, differences between males and females are minimal during early childhood 9 but begin to diverge during puberty, when differences in sex hormones are initiated [10][11][12] , and continue to become more distinct into young adulthood 9,13 .…”

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confidence: 99%

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Athleticism and sex impact neural processing of sound

Krizman

Bonacina

Colegrove

et al. 2022

Sci Rep

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Biology and experience both influence the auditory brain. Sex is one biological factor with pervasive effects on auditory processing. Females process sounds faster and more robustly than males. These differences are linked to hormone differences between the sexes. Athleticism is an experiential factor known to reduce ongoing neural noise, but whether it influences how sounds are processed by the brain is unknown. Furthermore, it is unknown whether sports participation influences auditory processing differently in males and females, given the well-documented sex differences in auditory processing seen in the general population. We hypothesized that athleticism enhances auditory processing and that these enhancements are greater in females. To test these hypotheses, we measured auditory processing in collegiate Division I male and female student-athletes and their non-athlete peers (total n = 1012) using the frequency-following response (FFR). The FFR is a neurophysiological response to sound that reflects the processing of discrete sound features. We measured across-trial consistency of the response in addition to fundamental frequency (F0) and harmonic encoding. We found that athletes had enhanced encoding of the harmonics, which was greatest in the female athletes, and that athletes had more consistent responses than non-athletes. In contrast, F0 encoding was reduced in athletes. The harmonic-encoding advantage in female athletes aligns with previous work linking harmonic encoding strength to female hormone levels and studies showing estrogen as mediating athlete sex differences in other sensory domains. Lastly, persistent deficits in auditory processing from previous concussive and repetitive subconcussive head trauma may underlie the reduced F0 encoding in athletes, as poor F0 encoding is a hallmark of concussion injury.

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“…First, auditory processing is predominantly female in animals and humans [20]. In particular, in humans, females have better auditory thresholds [15,16], sound-harmonics processing [21], and emotional signal processing [22] than males; thus, females may have been more sensitive to acoustical features than males. Second, these auditory ndings are consistent with many research ndings in the visual area.…”

Section: Participants' Response Patterns In the Saliency Acoustic Res...mentioning

confidence: 99%

Examination of sex differences in bottom-up auditory attention according to human behavioral judgments of the auditory saliency model

Obama

Satô

Akisada

et al. 2022

Preprint

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Many cognitive functions are related to sex. However, the relationship between auditory attention and sex remains unknown. This cross-sectional study aimed to assess sex differences in auditory saliency judgments according to bottom-up auditory attention. Forty-five normal adults (mean age: 21.5 ± 0.64 years) without hearing, intelligence, and attention deficits were enrolled. They listened to five audio stimuli played by a loudspeaker in a soundproof room and then annotated the attention-capturing sounds. Each stimulus contained 10 salient sounds (foreground tokens) randomly placed within a 1-minute natural soundscape (background token). Responses were confirmed for 77 sound events, with individual response rates of 4–100%. The overall and foreground token response rates were lower in females than in males (p < 0.01), but the background token response rate was higher in females (p < 0.001). In multiple regression analysis, only loudness influenced female response rates (p = 0.002); thus, females may be more influenced by loudness when making saliency judgments than males. This study is the first to report sex differences in auditory saliency judgments according to bottom-up auditory attention. In conclusion, sex differences should be considered when assessing bottom-up auditory attention.

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Sex differences in auditory processing vary across estrous cycle

Cited by 18 publications

References 37 publications

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Athleticism and sex impact neural processing of sound

Examination of sex differences in bottom-up auditory attention according to human behavioral judgments of the auditory saliency model

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