Sex Differences in Adiposity and Cardiovascular Diseases

Li, Haoyun; Konja, Daniels; Wang, Luyao; Wang, Yudong

doi:10.3390/ijms23169338

Cited by 17 publications

(10 citation statements)

References 240 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among variation factors, as reported elsewhere in dogs [ 52 , 53 ] and in other species (humans [ 54 ] and lambs [ 55 ]), the adiposity of adult dogs increased with age and neuter status. Contrary to what has been observed in humans [ 50 , 56 , 57 ], lambs [ 55 ] or pigs [ 58 ], no influence of sex on SFT values was observed in our population of Labradors. Further studies, including breed effect, are warranted to explore the parameters involved in the pattern of subcutaneous fat deposition in the canine species.…”

Section: Discussioncontrasting

confidence: 99%

Association between Birth Weight and Subcutaneous Fat Thickness at Adulthood in Dogs

Mugnier

Cellard

Morin

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

Overweight affects nearly 40% of dogs. The objective of this study was to explore the hypothesis of the Developmental Origins of Health and Disease through the association between birth weight and adiposity in adult dogs. The association between body condition score (BCS) and subcutaneous fat thickness (SFT), measured in the flanks, abdomen and lumbar regions, was assessed in a population 88 adult Labradors (>1 year). Significant positive moderate correlations between BCS and SFT were described. A linear mixed-effects model was used to investigate the association between birth weight and SFT by adjusting for sex, age, neuter status and the anatomical site of the measurement. The results showed that SFT values increased with age and were higher in sterilized than in entire dogs. In addition, SFT values were higher in the lumbar region compared to the other anatomical sites. Finally, the model revealed a significant association between SFT and birth weight, suggesting that, as in other species, dogs with the lowest birth weights have thicker subcutaneous fat at adulthood than the others. The assessment of visceral adipose tissue and the relative importance of birth weight among the numerous risk factors of overweight remains to be explored in dogs.

show abstract

Section: Discussioncontrasting

confidence: 99%

Association between Birth Weight and Subcutaneous Fat Thickness at Adulthood in Dogs

Mugnier

Cellard

Morin

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…In addition, significant men-women differences in sex hormone genetic traits [52][53][54], BMI genetic traits (obesity, waist/hip circumference, etc.) [55][56][57][58][59] and insulin/type 2 diabetes genetic traits [59,60] have been demonstrated at the GWAS level, which may be remarkable genetic predictors of sex-specific differences for cardiovascular diseases [61][62][63][64][65].…”

Section: Introductionmentioning

confidence: 99%

Sex-Specific Features of the Correlation between GWAS-Noticeable Polymorphisms and Hypertension in Europeans of Russia

Иванова

Churnosova

Abramova

et al. 2023

IJMS

View full text Add to dashboard Cite

The aim of the study was directed at studying the sex-specific features of the correlation between genome-wide association studies (GWAS)-noticeable polymorphisms and hypertension (HTN). In two groups of European subjects of Russia (n = 1405 in total), such as men (n = 821 in total: n = 564 HTN, n = 257 control) and women (n = 584 in total: n = 375 HTN, n = 209 control), the distribution of ten specially selected polymorphisms (they have confirmed associations of GWAS level with blood pressure (BP) parameters and/or HTN in Europeans) has been considered. The list of studied loci was as follows: (PLCE1) rs932764 A > G, (AC026703.1) rs1173771 G > A, (CERS5) rs7302981 G > A, (HFE) rs1799945 C > G, (OBFC1) rs4387287 C > A, (BAG6) rs805303 G > A, (RGL3) rs167479 T > G, (ARHGAP42) rs633185 C > G, (TBX2) rs8068318 T > C, and (ATP2B1) rs2681472 A > G. The contribution of individual loci and their inter-locus interactions to the HTN susceptibility with bioinformatic interpretation of associative links was evaluated separately in men’s and women’s cohorts. The men–women differences in involvement in the disease of the BP/HTN-associated GWAS SNPs were detected. Among women, the HTN risk has been associated with HFE rs1799945 C > G (genotype GG was risky; ORGG = 11.15 ppermGG = 0.014) and inter-locus interactions of all 10 examined SNPs as part of 26 intergenic interactions models. In men, the polymorphism BAG6 rs805303 G > A (genotype AA was protective; ORAA = 0.30 ppermAA = 0.0008) and inter-SNPs interactions of eight loci in only seven models have been founded as HTN-correlated. HTN-linked loci and strongly linked SNPs were characterized by pronounced polyvector functionality in both men and women, but at the same time, signaling pathways of HTN-linked genes/SNPs in women and men were similar and were represented mainly by immune mechanisms. As a result, the present study has demonstrated a more pronounced contribution of BP/HTN-associated GWAS SNPs to the HTN susceptibility (due to weightier intergenic interactions) in European women than in men.

show abstract

“…This female pattern of fat distribution is known to be associated with a more favourable cardiovascular risk at a similar BMI; however, ectopic fat deposition within the abdomen, pericardium and neck is more strongly implicated in women's adverse cardiovascular risk than that of men. Sex dimorphism in the heritability suggests that female fat distribution may be more genetically affected than males, and biological pathways are differentially involved in the determination of body fat distribution (30). The molecular mechanism for this sex dimorphism may also be beyond the modulation of sex hormones (31).…”

Section: Discussionmentioning

confidence: 99%

More than skin-deep: visceral fat is strongly associated with disease activity, function and metabolic indices in psoriatic disease

Blake

Gullick

Hutchinson

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective: To compare body composition between patients with psoriatic disease (PsD), including cutaneous psoriasis (PsO) and psoriatic arthritis (PsA), and controls, and to explore associations between disease activity and measures of function and metabolic derangement. Methods: Body composition was assessed by air displacement plethysmography (ADP) and MRI-derived fat segmentation using an automated pipeline (FatSegNet). Function was assessed by Health Assessment Questionnaire (HAQ) and metabolic status by fasting lipid profile, insulin and adiponectin. Active and inactive PsO and PsA was defined by body surface area (BSA) and Psoriasis Area Severity Index (PASI) and minimal disease activity (MDA) respectively. Results: 30 patients (median disease duration 15 y; median age 52 y) and 30 BMI-matched controls were enrolled. Compared with controls, all MRI-derived body composition parameters - whole-body volume, subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), abdominal adipose tissue (AAT), VAT/AAT and VAT/SAT - were significantly higher in the PsD group, specifically, those with active disease. Body mass, body fat, whole-body volume and whole-body VAT were correlated with higher triglycerides, cholesterol:HDL (high-density lipoprotein), insulin resistance and lower adiponectin as well as higher HAQ and a lower MDA. Conclusions: We provide the first evidence in patients with PsD for the clinical application of FatSegNet: a novel, automated and rapid deep learning pipeline for providing accurate MRI-based measures of fat segmentation. Patients with PsD revealed excessive total adipose tissue and a greater volume of metabolically unfavorable ectopic fat, including VAT, compared with BMI-matched controls, which correlated with HAQ, disease activity and overall metabolic dysfunction. Visceral fat is a surrogate marker of uncontrolled PsD and may be an important future therapeutic target. This study supports the need for more personalised strategies in PsD that consider the metabolic as well as inflammatory burden of disease.

show abstract

Sex Differences in Adiposity and Cardiovascular Diseases

Cited by 17 publications

References 240 publications

Association between Birth Weight and Subcutaneous Fat Thickness at Adulthood in Dogs

Association between Birth Weight and Subcutaneous Fat Thickness at Adulthood in Dogs

Sex-Specific Features of the Correlation between GWAS-Noticeable Polymorphisms and Hypertension in Europeans of Russia

More than skin-deep: visceral fat is strongly associated with disease activity, function and metabolic indices in psoriatic disease

Contact Info

Product

Resources

About