Sex Differences in Acute Heart Failure Management: Is There a Gap in Treatment Quality?

Collado-Lledó, Elena; Cuerda, Francisco de la; Solé, Albert Ariza

doi:10.1007/s11897-023-00593-2

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…Unique sex differences in the clinical phenotype of patients with AHF have been well-documented in previous studies [ 13 ]. Female patients with AHF are older and more likely to have hypertension, atrial fibrillation, valvular heart disease, diabetes, anemia, and depression [ 14 ]. In our data, female patients were older and tended to have a history of hypertension, whereas the incidence of atrial and ventricular arrhythmia was not significantly different from male patients.…”

Section: Discussionmentioning

confidence: 99%

“…In the previous study, PCI under Impella support was associated with greater survival benefits in female patients [ 3 ]. In another study, female patients rarely received PCI and MCS compared to male patients, resulting in higher in-hospital mortality [ 14 ]. In another study, Impella initiation prior to PCI was associated with significant reduction in inotrope use and may be associated with improved mortality and morbidity in patients with AMI-CS in both genders [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Sex-Related Differences in Short-Term Prognosis in Patients with Acute Myocardial Infarction-Related Cardiogenic Shock Receiving Impella Support in Japan: From the J-PVAD Registry

et al. 2023

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Background and Objectives: Sex-specific outcome in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS) receiving temporary mechanical circulatory support remains controversial. Materials and Methods: Patients with AMI-CS who received Impella support were prospectively enrolled in the Japanese registry for Percutaneous Ventricular Assist Device. Patients enrolled between January 2021 and December 2022 were considered to be eligible. Patients with out-of-hospital cardiac arrest and those without revascularization were excluded. The sex disparity in the 30-day survival after the initiation of Impella support was evaluated. Results: A total of 924 patients (median age 73 years; 21% female) were included. Female patients were older and had a smaller physiques than male patients (p < 0.05 for both). Female sex was significantly associated with a higher 30-day mortality after adjustment for four other potential confounders with a hazard ratio of 1.365 (95% confidence interval 1.026–1.816, p = 0.0324). In the female cohort, patients who received Impella prior to revascularization (N = 138) had a greater survival rate compared to those who received Impella after revascularization (68.1% versus 44.8%, p = 0.0015). Conclusions: Among the patients with AMI-CS who received Impella support and underwent revascularization, female sex was independently associated with a lower 30-day survival. For female patients, early initiation of Impella support prior to revascularization may improve their clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sex-Related Differences in Short-Term Prognosis in Patients with Acute Myocardial Infarction-Related Cardiogenic Shock Receiving Impella Support in Japan: From the J-PVAD Registry

et al. 2023

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Sex and cardiogenic shock: Still no time for answers but for evidences

Masiero

Tarantini

2023

International Journal of Cardiology

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Differential Effect of Sex on Mortality According to Age in Heart Failure

Lee,

Yoon,

Choi

et al. 2024

JAHA

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Background Heart failure exhibits sex‐based differences in prevalence, clinical characteristics, and outcomes. However, these differences may have an interaction with age. This study investigates these disparities in Asian patients with acute heart failure according to age. Methods and Results We pooled data from the KorHF (Korea Heart Failure) and the KorAHF (Korean Acute Heart Failure) registries including 3200 patients between 2005 and 2009 and 5625 patients between 2011 and 2014, respectively, hospitalized for acute heart failure in Korea. Patients were categorized by their age into 2 groups: those with age ≥70 years and those with age <70 years. The primary endpoint was in‐hospital and postdischarge outcomes according to sex, stratified by age. Of 8825 patients, 45.7% had an age <70 years, and 54.3% had an age ≥70 years. Women were older on average in both groups. Differences in baseline characteristics were more apparent in the older group, with women having a higher prevalence of hypertension and valvular heart disease, whereas more men had chronic kidney disease, previous myocardial infarction, chronic obstructive pulmonary disease, and strokes. Both in‐hospital and postdischarge mortalities showed differences only in the older group, with men dying more (5.08% versus 7.41%, P <0.001; 17.95% versus 22.20%, P <0.001 respectively). This pattern persisted to adjusted analyses, which revealed that men have a 54% (odds ratio, 1.54 [95% CI, 1.17–2.04]) and 30% (hazard ratio, 1.30 [95% CI, 1.13–1.51]) increased in‐hospital and 1‐year mortality, respectively, compared with women. Conclusions In patients hospitalized with acute heart failure, male sex is an independent predictor of mortality in older patients but not younger patients.

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Sex Differences in Acute Heart Failure Management: Is There a Gap in Treatment Quality?

Cited by 4 publications

References 53 publications

Sex-Related Differences in Short-Term Prognosis in Patients with Acute Myocardial Infarction-Related Cardiogenic Shock Receiving Impella Support in Japan: From the J-PVAD Registry

Sex-Related Differences in Short-Term Prognosis in Patients with Acute Myocardial Infarction-Related Cardiogenic Shock Receiving Impella Support in Japan: From the J-PVAD Registry

Sex and cardiogenic shock: Still no time for answers but for evidences

Differential Effect of Sex on Mortality According to Age in Heart Failure

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