Sex Differences and Tumor Blood Flow from Dynamic Susceptibility                    Contrast MRI Are Associated with Treatment Response after Chemoradiation and                    Long-term Survival in Rectal Cancer

Bakke, Kine Mari; Meltzer, Sebastian; Grøvik, Endre; Negård, Anne; Holmedal, Stein Harald; Gjesdal, Kjell-Inge; Bjørnerud, Atle; Ree, Anne Hansen; Redalen, Kathrine Røe

doi:10.1148/radiol.2020200287

Cited by 17 publications

(17 citation statements)

References 25 publications

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“…(18-20) Tumors with poor blood perfusion has less oxygen and nutrients, and the tumor has more severe hypoxia, thus mobilizing the tumor cells to leave the primary site to nd a more suitable survival site. (15) Tumors with poor prognosis have less blood ow, causing less blood re ux. Hence, there was no signi cant change in the drainage vein, and the diameter of the re ux vein was small.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of The Diameter of Superior Rectal Vein For Locally Advanced Rectal Cancer

Hong

Chen

et al. 2022

Preprint

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Objectives: The purpose of this study was to evaluate the association between the diameter of the superior rectal vein (dSRV) and prognosis in patients with locally advanced rectal cancer (LARC).Methods and materials: This retrospective study included 420 patients with LARC who received neoadjuvant therapy followed by total mesorectal resection (TME) from December 2014 to July 2017. The dSRV was measured before treatment. The maximal χ2 method was employed to determine the dSRV threshold of 3.6 mm based on the difference in disease-free survival, and then to divide the patients into 2 groups. The propensity score matching method (PSM) was used to balance the individual characteristics between the two groups. Kaplan–Meier curves and adjusted Cox models were used to determine the relationship among the baseline characteristics and overall survival (OS), disease-free survival (DFS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS).Results: During a median follow-up of 45 months, 7 patients had relapse (1.60%), and 71 had distant metastasis (16.90%). Kaplan–Meier survival curves showed that patients with a dSRV > 3.60 mm had better survival (dSRV > 3.60 mm vs. ≤ 3.60 mm: 3-y MFS: 87.70% vs. 68.20%, P < 0.001; 3-y DFS: 85.50% vs. 64.20%, p < 0.001; 3-y OS: 91.90% vs. 82.20%, p=0.005). The multivariate Cox regression analysis after adjusting the covariates and the multivariate Cox regression analysis after performing PSM showed that the dSRV was an independent prognostic factor for MFS, DFS and OS.Conclusion: The dSRV measurement is valuable in predicting the prognosis of patients with LARC, and the prognosis of patients with a smaller dSRV seems to be poor.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of The Diameter of Superior Rectal Vein For Locally Advanced Rectal Cancer

Hong

Chen

et al. 2022

Preprint

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“…Interestingly, CXCL7 has been proposed as a circulating biomarker for CRC detection [46]. With regard to vascular processes, we recently showed that hemodynamic factors of the rectal cancer differ and result in distinctive outcomes in men and women [47,48]. In our previous vitamin D study, a weak inverse correlation between circulating 25(OH) D and SIR markers appeared in all patients analyzed together [13]-it might be that stronger and more distinct modes of systemic inflammation with respect to the vitamin D status had been revealed if male and female patients had been analyzed separately.…”

Section: Discussionmentioning

confidence: 99%

Sex Disparities in Vitamin D Status and the Impact on Systemic Inflammation and Survival in Rectal Cancer

Abrahamsson

Meltzer

Hagen

et al. 2021

Preprint

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Background: We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating levels of 25-hydroxyvitamin D [25(OH)D] were low. Here we investigated whether the association between the vitamin D status and prognosis pertains to the general, unselected population of rectal cancer patients.Methods: Serum 25(OH)D at the time of diagnosis was assessed in 129 patients, enrolled 2013-2017 and representing the entire range of rectal cancer stages, and analyzed with respect to season, sex, systemic inflammation, and survival.Results: In the population-based cohort residing at latitude 60°N, 25(OH)D varied according to season in men only, who were overrepresented among the vitamin D-deficient (<50 nmol/L) patients. Consistent with our previous findings, the individuals presenting with T4 disease had significantly reduced 25(OH)D levels. Low vitamin D was associated with systemic inflammation, albeit with distinct modes of presentation. While men with low vitamin D showed circulating markers typical for the systemic inflammatory response (e.g., elevated erythrocyte sedimentation rate), the corresponding female patients had elevated serum levels of interleukin-6 and the chemokine (C-X-C motif) ligand 7. Despite disparities in vitamin D status and the potential effects on disease attributes, significantly shortened cancer-specific survival was observed in vitamin D-deficient patients irrespective of sex.Conclusion: This unselected rectal cancer cohort confirmed the interconnection of low vitamin D, more advanced disease presentation, and poor survival, and further suggested it may be conditional on disparate modes of adverse systemic inflammation in men and women.Trial registration: ClinicalTrials.gov NCT01816607; registration date: 22 March 2013.

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“…In particular, the ROC value in pre-treatment kurtosis was significantly higher than all other parameters (0.907, p < 0.001) [147]. Another prospective observational cohort study found that a lower baseline tumour blood flow from dynamic susceptibility contrast MRI was associated with better response to nCRT (p = 0.01) [148].…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 94%

Biomarkers for Predicting the Response to Radiation-Based Neoadjuvant Therapy in Rectal Cancer

Chen¹,

Yang²,

Chen³

et al. 2022

Front. Biosci. (Landmark Ed)

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Locally advanced rectal cancer (RC) is treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery. Currently, organ-sparing approaches and/or "watch-and-wait" strategies other than unnecessary surgery have been suggested as the best option for patients who achieve complete regression after neoadjuvant treatment. However, patients respond differently to nCRT, hence the urgent need for effective methods to predict whether individual rectal cancer patients could benefit from this treatment. In this review, we summarize the biomarkers reported to be potential predictors of the therapeutic response of RC to nCRT. Biomarkers that are associated with genes, ribonucleic acid (RNA) and proteins are summarized and described first, followed by other types including immune and tumour microenvironment-related biomarkers, imaging biomarkers, microbiome-associated biomarkers, and blood-based biomarkers.

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Sex Differences and Tumor Blood Flow from Dynamic Susceptibility Contrast MRI Are Associated with Treatment Response after Chemoradiation and Long-term Survival in Rectal Cancer

Cited by 17 publications

References 25 publications

Prognostic Significance of The Diameter of Superior Rectal Vein For Locally Advanced Rectal Cancer

Prognostic Significance of The Diameter of Superior Rectal Vein For Locally Advanced Rectal Cancer

Sex Disparities in Vitamin D Status and the Impact on Systemic Inflammation and Survival in Rectal Cancer

Biomarkers for Predicting the Response to Radiation-Based Neoadjuvant Therapy in Rectal Cancer

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