Sex differences and immune correlates of Long COVID development, persistence, and resolution
Rebecca E. Hamlin,
Shaun M. Pienkos,
Leslie Chan
et al.
Abstract:Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity and mortality during acute infection in males and a greater proportion of females developing LC. We hypothesized that sex-specific immune dysregulation contributes to the pathogenesis of LC. To investigate the immunologic underpinnings of LC development and persistence, we used single-cell transcriptomics, single-cell proteomics, and plasma proteomics on blood samples obtained during acute SARS-CoV-… Show more
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