Sex differences and estradiol involvement in hyperalgesia and allodynia in an experimental model of fibromyalgia

Hernandez-Leon, Alberto; Luz-Cuellar, Yarim Elideth De la; Granados‐Soto, Vinicio; González-Trujano, María Eva; Fernández‐Guasti, Alonso

doi:10.1016/j.yhbeh.2017.10.011

Cited by 30 publications

(21 citation statements)

References 75 publications

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“…The effect of OVX on chronic pain mechanisms remains inconclusive. Pain-related behaviors are observed in OVX rats [51,58,59], despite a report of less frequent tactile allodynia [60]. This model is often used to replicate climacteric diseases such as BMS, fibromyalgia, and osteoporotic pain.…”

Section: A Challenge In Elucidating the Etiology Of Bmsmentioning

confidence: 99%

A perspective from experimental studies of burning mouth syndrome

et al. 2020

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Burning mouth syndrome (BMS) is one of the most frequently seen idiopathic pain conditions in a dental setting. Peri-and postmenopausal women are most frequently affected, and patients who experience BMS complain of persistent burning pain mainly at the tip and the bilateral border of the tongue. Recent studies have assessed whether BMS is a neuropathic pain condition, based on morphologic changes in biopsied tongue specimens, and whether there are abnormal pain responses in patients with this disease. Somatosensory studies have reported some abnormal findings in sensory and pain detection thresholds with inconsistency; however, the most distinct finding was exaggerated responses to painful stimuli. Imaging and electrophysiologic studies have suggested the possibility of dysregulation of the pain-modulating system in the central nervous system, which may explain the enhanced pain responses despite the lack of typical responses toward quantitative sensory tests. Basic studies have suggested the possible involvement of neuroprotective steroids, although the underlying mechanisms of this condition have not been elucidated. Experimental studies are looking for preferable supportive therapies for BMS patients despite the obscure pathogenesis.

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Section: A Challenge In Elucidating the Etiology Of Bmsmentioning

confidence: 99%

A perspective from experimental studies of burning mouth syndrome

et al. 2020

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“…In the 28 studies, 3 936 364 men and 282 449 women with FM were examined. One study was a clinical trial [10] in which the impacts of a manual therapy intervention were assessed in both sexes and another study was a clinical trial performed in rats [16] designed to examine whether sex is a determining factor in the absence of ovarian hormones and in a setting of allodynia and hyperalgesia. The remaining studies are much needed descriptive, observational studies that have attempted to characterize these Most of the studies reviewed showed substantial differences in numbers of male and female participants with the exception of those by Castro et al [10] and Miró et al [22].…”

Section: Resultsmentioning

confidence: 99%

Differences Between Men and Women with Fibromyalgia

Úbeda-D’Ocasar

Gallego-Sendarrubias

Guodemar-Pérez

et al. 2020

Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin

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Objective While fibromyalgia (FM) affects both men and women, differences exist in several factors including prevalence, symptoms and attitudes. Understanding these differences will help define the best approach to the clinical management of this still poorly-understood disease. This systematic review sought to identify gender differences in FM. Data sources The databases PubMed, Science Direct, Scielo, Scopus, Web of Science, and Pesquisa were searched using the terms “fibromyalgia”, “men” and “women” and the Boolean operators “AND” and “OR” for articles dealing with this topic published in any language in the past 20 years. The task force initially identified citations for 257 published articles. Study selection Of 257 records extracted, 28 articles were finally selected for inclusion. Data Extraction In the 28 studies, 2 studies were a clinical trial and the remaining studies were descriptive (10), observational studies (12), retrospective studies (2) and prospective studies (2). Articles were abstracted and quality of the studies determined using specific criteria. Data Synthesis The methodological quality of the studies reported in these articles was good (PEDro score 6.00±1.3328). Gender differences were detected in FM prevalence, symptoms and coping. Conclusions Overall, men with FM experienced more stress and worse sleep quality while women complained more of pain-related symptoms. Both sexes showed low physical activity levels. Both men and women responded well to manual treatment reporting substantial pain relief.

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“…Finally, Hernandez‐Leon et al analyzed reserpine‐induced FM models and found that in the absence of ovarian hormones (ovariectomized rats) there was an increase in muscle nociceptors and exacerbating pain and also altered sleep architecture by the increase of total wake time (38%), diminution of the NREM stage (slow wave sleep [SWS]‐I 33% and SWS‐II 76%), and abolition of REM. This study also found that 17‐beta‐estradiol had analgesic and anti‐allodynic effects when administered to the animals, suggesting that it could be useful in this model of induced FM.…”

Section: Discussing the Interplay Between Menopause Fm And Sleepmentioning

confidence: 99%

Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review

et al. 2019

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Introduction Fibromyalgia (FM) symptoms worsen in a significant portion of patients with the onset of menopause. Some patients report that their symptoms begin after menopause, suggesting a relationship between these entities. Sleep disturbance is a common condition in FM and menopause, and it is associated with chronic pain. Methods/Objectives Several electronic databases were searched, from the first available year to April 2018 to evaluate the publications that assessed the effects of menopause and sleep disturbance on the appearance or worsening of FM and the role of hormone therapy for these patients. Results The results are summarized in three tables. The objective sleep patterns of FM patients included high sleep latency, frequent arousals and intrusion of alpha wave sleep and NREM (non‐rapid eye movement) sleep in delta sleep. Poor sleep during menopause is more frequent in late perimenopause and surgical menopause, and may be related to vasomotor symptoms or not. Hormone therapy exerted a positive effect on subjective sleep quality of symptomatic menopausal women. Studies have shown a high association between FM and early and surgical menopause. Raloxifene exerted a positive effect on pain and sleep in FM patients; however one study that analyzed the effects of transdermal estrogen therapy found no improvement in subjective and objective parameters of pain. Conclusion Further studies are needed to elucidate the nature of the association between menopause, sleep and persistent pain syndromes, such as FM, showing the role of hormone therapy in prospective placebo‐controlled trials.

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Sex differences and estradiol involvement in hyperalgesia and allodynia in an experimental model of fibromyalgia

Cited by 30 publications

References 75 publications

A perspective from experimental studies of burning mouth syndrome

A perspective from experimental studies of burning mouth syndrome

Differences Between Men and Women with Fibromyalgia

Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review

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