Sex difference in development of diabetes and cardiovascular disease on the way from obesity and metabolic syndrome

Onat, Altan; Hergenç, Gülay; Keleş, İbrahim; Doğan, Yüksel; Türkmen, Serdar; Sansoy, Vedat

doi:10.1016/j.metabol.2005.01.025

Cited by 56 publications

(37 citation statements)

References 25 publications

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“…Although some references do not mention sex as an independent risk factor for T2DM [43], the prevalence of T2DM was reported in several studies to be lower among women [44–46] especially in developed countries [47]. The male excess in the incidence and prevalence of T2DM, which is found in some populations, has been attributed to sex-related differences in insulin sensitivity, consequences of obesity and regional body fat deposition and other contributing factors such as hypertension, smoking and alcohol intake [48,49]. …”

Section: Discussionmentioning

confidence: 99%

Prevalence of pre-diabetes and type 2 diabetes mellitus among Sami and non-Sami men and women in Northern Norway – The SAMINOR 2 Clinical Survey

Naseribafrouei

Eliassen

Melhus

et al. 2018

International Journal of Circumpolar Health

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The aim of this study was to determine and compare the prevalence of pre-diabetes and type 2 diabetes mellitus (T2DM) among Sami and non-Sami men and women of rural districts in Northern Norway. The SAMINOR 2 Clinical Survey is a cross-sectional population-based study performed in 2012–2014 in 10 municipalities of Northern Norway. A total of 12,455 Sami and non-Sami inhabitants aged 40–79 years were invited to participate and 5878 were included in the analyses. Participants with self-reported T2DM and/or a glycated haemoglobin (HbA1c) result ≥6.5% were categorised as having T2DM. Those with 5.7%≤HbA1c<6.5% were categorised as pre-diabetics. In men, the total age-standardised prevalence of pre-diabetes (37.9% vs 31.4%) and T2DM (10.8% vs 9.5%) were higher in Sami compared with non-Sami; the ethnic difference was statistically significant for both pre-diabetes (OR 1.42, p < 0.001) and T2DM (OR 1.31, p = 0.042). In women, pre-diabetes (36.4% vs 33.5%) and T2DM (8.6% vs 7.0%) were also more common in Sami than non-Sami; the differences in both pre-diabetes (OR 1.20, p = 0.025) and T2DM (OR 1.38, p = 0.021) were also statistically significant. The observed ethnic difference in the waist-to-height ratio (WHtR) was a plausible explanation for the ethnic difference in the prevalence of pre-diabetes and T2DM.

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Section: Discussionmentioning

confidence: 99%

Prevalence of pre-diabetes and type 2 diabetes mellitus among Sami and non-Sami men and women in Northern Norway – The SAMINOR 2 Clinical Survey

Naseribafrouei

Eliassen

Melhus

et al. 2018

International Journal of Circumpolar Health

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“…The Turkish Adult Risk Factor Study reports that cardiovascular risk factors are highly prevalent in Turkish adults [14]. Epidemological studies display that MetS is extremely common (40%) among Turkish postmenopausal women [12]. Low SHBG level is an established biomarker of insulin resistance and hyperinsulinemia [15].…”

Section: Murat Sunbul Et Al Shbg Gene Polymorphisms and Metabolic Smentioning

confidence: 99%

“…Metabolic syndrome is extremely common (40%) among Turkish postmenopausal women [12]. We aim to examine the association between the SHBG gene polymorphisms (rs1799941 A/G and rs6257 T/C) and MetS risk components among postmenopausal Turkish women.…”

Section: Introductionmentioning

confidence: 99%

Sex hormone binding globulin gene polymorphisms and metabolic syndrome in postmenopausal Turkish women

Sünbül

Eren²,

Nacar³

et al. 2013

Cardiol J

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“…Studies have found that changes in weight and adipose tissue contents can affect insulin resistance. Elevated blood glucose level, a component of MetS in women, was also found to cause higher vulnerability to diabetes incidence in spite of normal glucose metabolism (20,21). Serum concentrations of HDL-c and TG are other risk factors of MetS.…”

Section: Introductionmentioning

confidence: 99%

Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population

Eftekhari¹,

Sohrabi²,

Parsa³

et al. 2015

Int Cardiovasc Res J

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obesity secondary to medication and genetic or endocrine disorders were excluded from the study. Weight and height were measured for calculating Body Mass Index (BMI). Waist circumference and blood pressure were measured, as well. Plasma glucose, serum High Density Lipoprotein-cholesterol (HDL-c), and Triglyceride (TG) were also analyzed. The presence of MetS was determined using Adult Treatment Panel-III (ATP-III) criteria. Results:The results showed significant correlations between age and waist circumference, Fasting Blood Sugar (FBS), Systolic Blood Pressure (SBP), and Diastolic Blood Pressure (DBP). Moreover, statistically significant relationships were found between waist circumference and TG, SBP, DBP, and BMI. Significant correlations were also observed between FBS and TG, SBP, and DBP. Besides, there were strong correlations between TG and HDL-c, SBP, DBP, and BMI. Moreover, BMI, SBP, and DBP were significantly correlated. In addition, serum HDL-c was negatively associated with most of the variables. The prevalence of pre-diabetes, pre-hypertension, and hypertriglyceridemia was higher among males. On the other hand, the prevalence of hypertension, diabetes, high waist circumference, and MetS was significantly higher among the female participants. Conclusions: A better understanding of the role of gender in the prevalence of MetS is important in developing prevention and treatment strategies.

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Sex difference in development of diabetes and cardiovascular disease on the way from obesity and metabolic syndrome

Cited by 56 publications

References 25 publications

Prevalence of pre-diabetes and type 2 diabetes mellitus among Sami and non-Sami men and women in Northern Norway – The SAMINOR 2 Clinical Survey

Prevalence of pre-diabetes and type 2 diabetes mellitus among Sami and non-Sami men and women in Northern Norway – The SAMINOR 2 Clinical Survey

Sex hormone binding globulin gene polymorphisms and metabolic syndrome in postmenopausal Turkish women

Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population

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