Sex-difference in air pollution-related acute circulatory and respiratory mortality and hospitalization

Shin, Hwashin Hyun; Maquiling, Aubrey; Thomson, Errol M.; Park, In Woo; Stieb, Dave; Dehghani, Parvin

doi:10.1016/j.scitotenv.2021.150515

Cited by 44 publications

(20 citation statements)

References 68 publications

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“…To the best of our knowledge, no previous studies have evaluated and compared the effects of air pollutants on the incidence, progress, and prognosis of CMM simultaneously, which would have significant implications in the evidence-based prevention and intervention. In addition, premature death from other causes than CMDs may mask the risk of CMD and CMM, 10 resulting in a competing risk from death when evaluating the association between air pollution and CMM. 11 However, no prior studies had taken competing risk into consideration, which may lead to overestimation of the estimates.…”

Section: Introductionmentioning

confidence: 99%

Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: A prospective study in the UK Biobank

Luo¹,

Zhang²,

et al. 2022

eBioMedicine

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Section: Introductionmentioning

confidence: 99%

Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: A prospective study in the UK Biobank

Luo¹,

Zhang²,

et al. 2022

eBioMedicine

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“…A study conducted in southern China showed that the risk of IHD death from short-term exposure to SO 2 was greater in women than in men [ 20 ]. A recent study in Canada reported that females were at higher risks of IHD hospitalization from NO 2 exposure than males [ 43 ]. Altered sensitivity to air pollutants may be related to physiological differences because of the hormonal, biological, structural, and morphological differences between men and women, which directly affect the transport of exposed chemicals and the deposition in tissues [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of Air Pollution on Ischemic Heart Disease Hospitalizations: A Population-Based Time-Series Study in Wuhan, China, 2017–2018

Liu²,

Huang

et al. 2021

IJERPH

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Evidence of the acute effects of air pollutants on ischemic heart disease (IHD) hospitalizations based on the entire population of a megacity in central China is lacking. All IHD hospitalization records from 2017 to 2018 were obtained from the Wuhan Information Center of Health and Family Planning. Daily air pollutant concentrations and meteorological data were synchronously collected from the Wuhan Environmental Protection Bureau. A time-series study using generalized additive models was conducted to systematically examine the associations between air pollutants and IHD hospitalizations. Stratified analyses by gender, age, season, hypertension, diabetes, and hyperlipidemia were performed. In total, 139,616 IHD hospitalizations were included. Short-term exposure to air pollutants was positively associated with IHD hospitalizations. The age group ≥76 was at higher exposure risk, and the associations appeared to be more evident in cold seasons. PM2.5 and PM10 appeared to have greater effects on males and those without hypertension or diabetes, whereas NO2 and SO2 had greater effects on females and those with hypertension or diabetes. The risk of IHD hospitalization due to air pollutants was greater in people without hyperlipidemia. Our study provides new evidence of the effects of air pollution on the increased incidence of IHD in central China.

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“…Sex is a biological variable with significant influence over various physiological functions within all species. Specifically, with regard to lung physiology and immune responses, the factor of sex greatly affects the prognosis of pulmonary morbidities in response to air pollution [ 1 , 2 , 3 , 4 ]. Historically, within the literature, causal relationships have been made between air pollution and morbidity and/or mortality by various factors such as genetic susceptibility, environment, and even socioeconomic status.…”

Section: Introductionmentioning

confidence: 99%

“…However, little attention has been given to sex differences, especially in animal models. A recent study in Canada was able to analyze nearly three decades of mortality data and hospitalizations along with health outcomes from a geographically diverse cohort representing nearly half of the country as they relate to health effects resulting from air pollution exposure [ 4 ]. Shin and colleagues found that, in response to short term exposure to ambient air pollution, there were pollutant season-specific sex differences in circulatory and respiratory hospitalization and mortality where males were at higher risk for warm season, but females were at higher risk than males for cold season [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific

Valdez

Freeborn

Vulimiri

et al. 2023

IJMS

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Exposure to a prototypic air pollutant ozone (O3) has been associated with the activation of neuroendocrine stress response along with neural changes in oxidative stress (OS), inflammation, and Alzheimer’s disease-like pathologies in susceptible animal models. We hypothesized that neural oxidative and transcriptional changes induced by O3 in stress responsive regions are sex-dependent. Male and female adult Long–Evans rats were exposed to filtered air or O3 for two consecutive days (0.8 ppm, 4 h/day) and brain regions were flash-frozen. Activities of cerebellar OS parameters and mitochondrial complex I, II, and IV enzymes were assessed to confirm prior findings. We assessed transcriptional changes in hypothalamus (HYP) and hippocampus (HIP) for markers of OS, microglial activity and glucocorticoid signaling using qPCR. Although there were no O3 or sex-related differences in the cerebellar activities of OS and mitochondrial enzymes, the levels of protein carbonyls and complex II activities were higher in females regardless of O3. There were no statistical differences in baseline expression of genes related to OS (Cat, Dhcr24, Foxm1, Gpx1, Gss, Nfe2l2, Sod1) except for lower HYP Sod1 expression in air-exposed females than males, and higher HIP Gss expression in O3-exposed females relative to matched males. Microglial marker Aif1 expression was higher in O3-exposed females relative to males; O3 inhibited Itgam only in males. The expression of Bdnf in HIP and HYP was inhibited by O3 in both sexes. Genes related to glucocorticoid signaling (Fkbp4, Fkbp5, Hsp90aa1, Hspa4, nr3c1, nr3c2) showed sex-specific effects due to O3 exposure. Baseline expression of HIP Fkbp4 was higher in females relative to males. O3 inhibited Nr3c1 in female HIP and male HYP, but Nr3c2 was inhibited in male HYP. Fkbp4 expression was higher in O3-exposed females when compared to matched males, whereas Fkbp5 was expressed at higher levels in both brain regions of males and females. These results indicate that sex-specific brain region responses to O3 might, in part, be caused by OS and regulation of glucocorticoid signaling.

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Sex-difference in air pollution-related acute circulatory and respiratory mortality and hospitalization

Cited by 44 publications

References 68 publications

Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: A prospective study in the UK Biobank

Long-term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: A prospective study in the UK Biobank

Acute Effects of Air Pollution on Ischemic Heart Disease Hospitalizations: A Population-Based Time-Series Study in Wuhan, China, 2017–2018

Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus Are Sex-Specific

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